(Q34115304)

31 July 2017

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title

Targeting mitochondria for cancer therapy. (English)

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31 July 2017

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2

Lorenzo Galluzzi

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Guido Kroemer

series ordinal

3

object named as

Guido Kroemer

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Simone Fulda

series ordinal

1

object named as

Simone Fulda

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publication date

14 May 2010

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Nature Reviews Drug Discovery

31 July 2017

published in

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31 July 2017

volume

9

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31 July 2017

issue

6

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31 July 2017

page(s)

447-464

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https://scigraph.springernature.com/pub.10.1038/nrd3137

31 July 2017

exact match

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cites work

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Tumor resistance to apoptosis

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Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy

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Mitochondrial membrane permeabilization in cell death

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No death without life: vital functions of apoptotic effectors

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Necroptosis: a specialized pathway of programmed necrosis

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Cell death by necrosis: towards a molecular definition

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Mitochondria in cancer cells: what is so special about them?

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Association of reactive oxygen species levels and radioresistance in cancer stem cells

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Tumor cell metabolism: cancer's Achilles' heel

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Mitochondrial dysfunction in cancer

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Mitochondrial DNA G10398A polymorphism and invasive breast cancer in African-American women

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mtDNA mutations increase tumorigenicity in prostate cancer

31 March 2020

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Mitochondrial gateways to cancer

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Mitochondrial medicine: pharmacological targeting of mitochondria in disease

31 March 2020

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Mitochondria as therapeutic targets for cancer chemotherapy

31 March 2020

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Mitochondria as targets for cancer chemotherapy

31 March 2020

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Measuring apoptosis at the single cell level

31 March 2020

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Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

31 March 2020

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Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

31 March 2020

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Mitochondrial apoptosis without VDAC

31 March 2020

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The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

31 March 2020

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Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

31 March 2020

1 reference

Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells.

31 March 2020

1 reference

Adenine nucleotide translocase-1, a component of the permeability transition pore, can dominantly induce apoptosis

31 March 2020

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Chemosensitization by knockdown of adenine nucleotide translocase-2.

31 March 2020

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Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis

31 March 2020

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Adenine nucleotide translocator cooperates with core cell death machinery to promote apoptosis in Caenorhabditis elegans.

31 March 2020

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Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery

31 March 2020

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A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells.

31 March 2020

1 reference

Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437.

31 March 2020

1 reference

Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme

31 March 2020

1 reference

Lonidamine significantly increases the activity of epirubicin in patients with advanced breast cancer: results from a multicenter prospective randomized trial

31 March 2020

1 reference

Addition of either lonidamine or granulocyte colony-stimulating factor does not improve survival in early breast cancer patients treated with high-dose epirubicin and cyclophosphamide

31 March 2020

1 reference

Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite.

31 March 2020

1 reference

Adjuvant oral clodronate improves the overall survival of primary breast cancer patients with micrometastases to the bone marrow: a long-term follow-up

31 March 2020

1 reference

Antitumor effects of bisphosphonates

31 March 2020

1 reference

Bisphosphonates suppress insulin-like growth factor 1-induced angiogenesis via the HIF-1alpha/VEGF signaling pathways in human breast cancer cells

31 March 2020

1 reference

Current issues in the management of acute promyelocytic leukemia

31 March 2020

1 reference

All-trans-retinoic acid binds to and inhibits adenine nucleotide translocase and induces mitochondrial permeability transition

31 March 2020

1 reference

Antitumor Activity of the Retinoid-Related Molecules (E)-3-(4'-Hydroxy-3'-adamantylbiphenyl-4-yl)acrylic Acid (ST1926) and 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene Carboxylic Acid (CD437) in F9 Teratocarcinoma: Role of Retinoic Acid Receptor

31 March 2020

1 reference

Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of ST1926, a novel oral antitumor agent, adamantyl retinoid derivative, in plasma of patients in a Phase I study

31 March 2020

1 reference

Up-regulation of the peripheral benzodiazepine receptor during human colorectal carcinogenesis and tumor spread

31 March 2020

1 reference

Immunohistochemical assessment of the peripheral benzodiazepine receptor in breast cancer and its relationship with survival

31 March 2020

1 reference

Pk11195, a mitochondrial benzodiazepine receptor antagonist, reduces apoptosis threshold in Bcl-X(L) and Mcl-1 expressing human cholangiocarcinoma cells

31 March 2020

1 reference

PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor

31 March 2020

1 reference

PK11195, a peripheral benzodiazepine receptor (pBR) ligand, broadly blocks drug efflux to chemosensitize leukemia and myeloma cells by a pBR-independent, direct transporter-modulating mechanism

31 March 2020

1 reference

Benzoquinone inhibits the voltage-dependent induction of the mitochondrial permeability transition caused by redox-cycling naphthoquinones.

31 March 2020

1 reference

Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis

31 March 2020

1 reference

Phase I trial of menadiol diphosphate (vitamin K3) in advanced malignancy

31 March 2020

1 reference

Motexafin gadolinium: a novel redox active drug for cancer therapy

31 March 2020

1 reference

Motexafin gadolinium combined with prompt whole brain radiotherapy prolongs time to neurologic progression in non-small-cell lung cancer patients with brain metastases: results of a phase III trial

31 March 2020

1 reference

Motexafin gadolinium and involved field radiation therapy for intrinsic pontine glioma of childhood: a Children's Oncology Group phase I study

31 March 2020

1 reference

An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone

31 March 2020

1 reference

Effective treatment of advanced solid tumors by the combination of arsenic trioxide and L-buthionine-sulfoximine

31 March 2020

1 reference

Phase I trial of imexon in patients with advanced malignancy

31 March 2020

1 reference

A phase I trial of imexon, a pro-oxidant, in combination with docetaxel for the treatment of patients with advanced breast, non-small cell lung and prostate cancer.

31 March 2020

1 reference

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

31 March 2020

1 reference

Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential

31 March 2020

1 reference

Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir.

31 March 2020

1 reference

Superoxide dismutase as a target for the selective killing of cancer cells

31 March 2020

1 reference

Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling

31 March 2020

1 reference

Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide

31 March 2020

1 reference

Reactive oxygen species may have antitumor activity in metastatic melanoma

31 March 2020

1 reference

Activity of 2 methoxyestradiol (Panzem NCD) in advanced, platinum-resistant ovarian cancer and primary peritoneal carcinomatosis: a Hoosier Oncology Group trial.

31 March 2020

1 reference

Phase I trial of 2-methoxyestradiol NanoCrystal dispersion in advanced solid malignancies

31 March 2020

1 reference

Novel therapy with 2-methoxyestradiol for the treatment of relapsed and plateau phase multiple myeloma

31 March 2020

1 reference

A phase II multicenter, randomized, double-blind, safety trial assessing the pharmacokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in hormone-refractory prostate cancer

31 March 2020

1 reference

Phase II, randomized, controlled, double-blinded trial of weekly elesclomol plus paclitaxel versus paclitaxel alone for stage IV metastatic melanoma

31 March 2020

1 reference

Phase I clinical trial of STA-4783 in combination with paclitaxel in patients with refractory solid tumors

31 March 2020

1 reference

Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario

31 March 2020

1 reference

Life in the balance: how BH3-only proteins induce apoptosis.

31 March 2020

1 reference

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

31 March 2020

1 reference

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

31 March 2020

1 reference

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

31 March 2020

1 reference

BAX activation is initiated at a novel interaction site

31 March 2020

1 reference

TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax.

31 March 2020

1 reference

TOM-independent complex formation of Bax and Bak in mammalian mitochondria during TNFalpha-induced apoptosis

31 March 2020

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Bax activates endophilin B1 oligomerization and lipid membrane vesiculation

31 March 2020

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

31 March 2020

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Contributions to Bax insertion and oligomerization of lipids of the mitochondrial outer membrane

31 March 2020

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Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

31 March 2020

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OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion

31 March 2020

1 reference

BCL-2 family antagonists for cancer therapy

31 March 2020

1 reference

Bcl-2 inhibitors: small molecules with a big impact on cancer therapy

31 March 2020

1 reference

Different forms of cell death induced by putative BCL2 inhibitors.

31 March 2020

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

31 March 2020

1 reference

Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

31 March 2020

1 reference

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

31 March 2020

1 reference

In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas

31 March 2020

1 reference

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

31 March 2020

1 reference

Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo.

31 March 2020

1 reference

Alteration of the mitochondrial apoptotic pathway is key to acquired paclitaxel resistance and can be reversed by ABT-737.

31 March 2020

1 reference

Therapeutic efficacy of ABT-737, a selective inhibitor of BCL-2, in small cell lung cancer

31 March 2020

1 reference

Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins

31 March 2020

1 reference

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

31 March 2020

1 reference

Apoptosis-based dual molecular targeting by INNO-406, a second-generation Bcr-Abl inhibitor, and ABT-737, an inhibitor of antiapoptotic Bcl-2 proteins, against Bcr-Abl-positive leukemia

31 March 2020

1 reference

BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts.

31 March 2020

1 reference

Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics

31 March 2020

1 reference

Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas

31 March 2020

1 reference

Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic

31 March 2020

1 reference

The BH3-only mimetic ABT-737 synergizes the antineoplastic activity of proteasome inhibitors in lymphoid malignancies

31 March 2020

1 reference

BH3 mimetic ABT-737 and a proteasome inhibitor synergistically kill melanomas through Noxa-dependent apoptosis.

31 March 2020

1 reference

Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors

31 March 2020

1 reference

BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells

31 March 2020

1 reference

ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosis

31 March 2020

1 reference

The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia.

31 March 2020

1 reference

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

31 March 2020

1 reference

Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program

31 March 2020

1 reference

A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo

31 March 2020

1 reference

Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy.

31 March 2020

1 reference

An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer

31 March 2020

1 reference

Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).

31 March 2020

1 reference

Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

31 March 2020

1 reference

Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma

31 March 2020

1 reference

The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak

31 March 2020

1 reference

Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).

31 March 2020

1 reference

Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia

31 March 2020

1 reference

A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies

31 March 2020

1 reference

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

31 March 2020

1 reference

The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death.

31 March 2020

1 reference

Phase I/II study of G3139 (Bcl-2 antisense oligonucleotide) in combination with doxorubicin and docetaxel in breast cancer.

31 March 2020

1 reference

Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia

31 March 2020

1 reference

Phase I Trial of G3139, a bcl-2 antisense oligonucleotide, combined with doxorubicin and cyclophosphamide in children with relapsed solid tumors: a Children's Oncology Group Study

31 March 2020

1 reference

Randomized phase II Study of carboplatin and etoposide with or without the bcl-2 antisense oligonucleotide oblimersen for extensive-stage small-cell lung cancer: CALGB 30103.

31 March 2020

1 reference

Phase III randomised study of dexamethasone with or without oblimersen sodium for patients with advanced multiple myeloma.

31 March 2020

1 reference

2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells

31 March 2020

1 reference

Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity

31 March 2020

1 reference

Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels

31 March 2020

1 reference

Disruption of the hexokinase-VDAC complex for tumor therapy

31 March 2020

1 reference

Methyl jasmonate binds to and detaches mitochondria-bound hexokinase

31 March 2020

1 reference

Apoptosis-inducing antitumor efficacy of hexokinase II inhibitor in hepatocellular carcinoma.

31 March 2020

1 reference

Synergistic antipancreatic tumor effect by simultaneously targeting hypoxic cancer cells with HSP90 inhibitor and glycolysis inhibitor

31 March 2020

1 reference

Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate

31 March 2020

1 reference

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

31 March 2020

1 reference

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

31 March 2020

1 reference

ATP citrate lyase inhibition can suppress tumor cell growth

31 March 2020

1 reference

ATP-citrate lyase links cellular metabolism to histone acetylation

31 March 2020

1 reference

Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells

31 March 2020

1 reference

Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model

31 March 2020

1 reference

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

31 March 2020

1 reference

Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network.

31 March 2020

1 reference

VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase

31 March 2020

1 reference

Rational design of shepherdin, a novel anticancer agent.

31 March 2020

1 reference

Antileukemic activity of shepherdin and molecular diversity of hsp90 inhibitors.

31 March 2020

1 reference

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

31 March 2020

1 reference

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer

31 March 2020

1 reference

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

31 March 2020

1 reference

Terpenes: substances useful in human healthcare.

31 March 2020

1 reference

Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.

31 March 2020

1 reference

Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection

31 March 2020

1 reference

Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

31 March 2020

1 reference

Paclitaxel targets mitochondria upstream of caspase activation in intact human neuroblastoma cells.

31 March 2020

1 reference

Effects of betulinic acid alone and in combination with irradiation in human melanoma cells

31 March 2020

1 reference

Betulinic acid: a new cytotoxic compound against malignant head and neck cancer cells

31 March 2020

1 reference

Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors.

31 March 2020

1 reference

p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma

31 March 2020

1 reference

Betulinic acid reduces ultraviolet-C-induced DNA breakage in congenital melanocytic naeval cells: evidence for a potential role as a chemopreventive agent.

31 March 2020

1 reference

Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells

31 March 2020

1 reference

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

31 March 2020

1 reference

Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols

31 March 2020

1 reference

Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2.

31 March 2020

1 reference

Mitochondrial ATP synthasome: three-dimensional structure by electron microscopy of the ATP synthase in complex formation with carriers for Pi and ADP/ATP.

31 March 2020

1 reference

Development of mitochondria-targeted derivatives of resveratrol

31 March 2020

1 reference

A novel resveratrol derivative, HS1793, overcomes the resistance conferred by Bcl-2 in human leukemic U937 cells

31 March 2020

1 reference

The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development

31 March 2020

1 reference

Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent

31 March 2020

1 reference

Vitamin E and cancer: An insight into the anticancer activities of vitamin E isomers and analogs

31 March 2020

1 reference

Vitamin E analogues as mitochondria-targeting compounds: from the bench to the bedside?

31 March 2020

1 reference

In vivo and in vitro studies of anticancer actions of alpha-TEA for human prostate cancer cells

31 March 2020

1 reference

Dietary administration of the proapoptotic vitamin E analogue alpha-tocopheryloxyacetic acid inhibits metastatic murine breast cancer

31 March 2020

1 reference

Comparison of vitamin E derivatives alpha-TEA and VES in reduction of mouse mammary tumor burden and metastasis.

31 March 2020

1 reference

Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II.

31 March 2020

1 reference

Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II.

31 March 2020

1 reference

Vitamin E Analogues Inhibit Angiogenesis by Selective Induction of Apoptosis in Proliferating Endothelial Cells: The Role of Oxidative Stress

31 March 2020

1 reference

Induction of cancer cell apoptosis by alpha-tocopheryl succinate: molecular pathways and structural requirements

31 March 2020

1 reference

Enhanced antioxidant and cytoprotective abilities of vitamin E succinate is associated with a rapid uptake advantage in rat hepatocytes and mitochondria

31 March 2020

1 reference

Effects of alpha-tocopherol and beta-carotene supplementation on upper aerodigestive tract cancers in a large, randomized controlled trial

31 March 2020

1 reference

Susceptibility of cholangiocarcinoma cells to parthenolide-induced apoptosis

31 March 2020

1 reference

The sesquiterpene lactone parthenolide induces selective apoptosis of B-chronic lymphocytic leukemia cells in vitro

31 March 2020

1 reference

Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis.

31 March 2020

1 reference

An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells.

31 March 2020

1 reference

The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells

31 March 2020

1 reference

Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells.

31 March 2020

1 reference

The increasing complexity of the cancer stem cell paradigm

31 March 2020

1 reference

Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell

31 March 2020

1 reference

Newborn neurons acquire high levels of reactive oxygen species and increased mitochondrial proteins upon differentiation from progenitors.

31 March 2020

1 reference

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

31 March 2020

1 reference

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

31 March 2020

1 reference

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

31 March 2020

1 reference

Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

31 March 2020

1 reference

The role of oxygen availability in embryonic development and stem cell function

31 March 2020

1 reference

Hypoxia signalling controls metabolic demand

31 March 2020

1 reference

Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II.

31 March 2020

1 reference

AKT/PKB signaling: navigating downstream

31 March 2020

1 reference

Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells.

31 March 2020

1 reference

Pyruvate kinase M2 is a phosphotyrosine-binding protein

31 March 2020

1 reference

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

31 March 2020

1 reference

p53 regulates mitochondrial respiration

31 March 2020

1 reference

31 March 2020

1 reference

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

31 March 2020

1 reference

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

31 March 2020

1 reference

Mitochondrial tumour suppressors: a genetic and biochemical update

31 March 2020

1 reference

Selective targeting of bioactive compounds to mitochondria

31 March 2020

1 reference

Methods for the assessment of mitochondrial membrane permeabilization in apoptosis

31 March 2020

1 reference

Targeting mitochondria with organelle-specific compounds: strategies and applications

31 March 2020

1 reference

Cell-penetrating peptides do not cross mitochondrial membranes even when conjugated to a lipophilic cation: evidence against direct passage through phospholipid bilayers.

31 March 2020

1 reference

Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties

31 March 2020

1 reference

Mitochondria-penetrating peptides: sequence effects and model cargo transport

31 March 2020

1 reference

Translocation of proteins into mitochondria

31 March 2020

1 reference

Bacterial signal peptide recognizes HeLa cell mitochondrial import receptors and functions as a mitochondrial leader sequence

31 March 2020

1 reference

DNA-protein conjugates can enter mitochondria via the protein import pathway.

31 March 2020

1 reference

Manipulating mitochondrial DNA heteroplasmy by a mitochondrially targeted restriction endonuclease

31 March 2020

1 reference

Mitochondria-penetrating peptides

31 March 2020

1 reference

Guanidine-Containing Molecular Transporters: Sorbitol-Based Transporters Show High Intracellular Selectivity toward Mitochondria

31 March 2020

1 reference

MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion

31 March 2020

1 reference

DQAsomes: a novel potential drug and gene delivery system made from Dequalinium

31 March 2020

1 reference

Chapter Eighteen Methods to Dissect Mitochondrial Membrane Permeabilization in the Course of Apoptosis

31 March 2020

1 reference

Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis

31 March 2020

1 reference

Mitochondrial drug delivery and mitochondrial disease therapy--an approach to liposome-based delivery targeted to mitochondria

31 March 2020

1 reference

Display technologies: application for the discovery of drug and gene delivery agents

31 March 2020

1 reference

Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism

31 March 2020

1 reference

Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins

31 March 2020

1 reference

Elesclomol induces cancer cell apoptosis through oxidative stress

31 March 2020

1 reference

Peripheral benzodiazepine receptor ligands reverse apoptosis resistance of cancer cells in vitro and in vivo.

31 March 2020

1 reference

12 December 2020

Inhibition of superoxide dismutase by 2-methoxyoestradiol analogues and oestrogen derivatives: structure-activity relationships.

1 reference

12 December 2020

Bcl-2 and Bax modulate adenine nucleotide translocase activity.

1 reference

12 December 2020

Betulinic acid-induced programmed cell death in human melanoma cells involves mitogen-activated protein kinase activation

1 reference

12 December 2020

The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid can trigger apoptosis through a mitochondrial pathway independent of the nucleus.

1 reference

12 December 2020

Betulinic acid-induced apoptosis in glioma cells: A sequential requirement for new protein synthesis, formation of reactive oxygen species, and caspase processing

1 reference

12 December 2020

The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents.

1 reference

12 December 2020

Mitochondria: from bioenergetics to the metabolic regulation of carcinogenesis.

1 reference

12 December 2020

Betulinic acid-induced Mcl-1 expression in human melanoma--mode of action and functional significance

1 reference

12 December 2020

Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells

1 reference

12 December 2020

Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors

1 reference

12 December 2020

BCL-2 gene family and the regulation of programmed cell death

1 reference

12 December 2020

High dose vitamin K3 infusion in advanced hepatocellular carcinoma

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD3137

1 reference

Dimensions Publication ID

31 July 2017

1003013338

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1 reference