(Q45916401)

17 December 2017

title

The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia. (English)

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17 December 2017

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9

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17 December 2017

Andrew W. Roberts

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17 December 2017

Walter D Fairlie

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object named as

W D Fairlie

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17 December 2017

author name string

K D Mason

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17 December 2017

S L Khaw

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17 December 2017

K C Rayeroux

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17 December 2017

E Chew

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17 December 2017

E F Lee

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17 December 2017

A P Grigg

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17 December 2017

J F Seymour

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D C S Huang

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17 December 2017

publication date

30 July 2009

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17 December 2017

published in

Leukemia

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17 December 2017

volume

23

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17 December 2017

issue

11

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17 December 2017

page(s)

2034-2041

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Chronic lymphocytic leukemia

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

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21 January 2018

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Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia

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7 January 2021

ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile

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7 January 2021

Analysis of clonal B-cell CD38 and immunoglobulin variable region sequence status in relation to clinical outcome for B-chronic lymphocytic leukaemia

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7 January 2021

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7 January 2021

TP53 deletions but not trisomy 12 are adverse in B-cell lymphoproliferative disorders

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7 January 2021

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7 January 2021

Spontaneous programmed death (apoptosis) of B-chronic lymphocytic leukaemia cells following their culture in vitro

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7 January 2021

Identifiers

DOI

10.1038/LEU.2009.151

1 reference

17 December 2017

Dimensions Publication ID

1049451785

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1 reference

17 December 2017