(Q37059647)

18 August 2017

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title

Diagnosing and exploiting cancer's addiction to blocks in apoptosis (English)

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18 August 2017

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Anthony G Letai

1

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PubMed ID

18202696

18 August 2017

language of work or name

English

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publication date

1 February 2008

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18 August 2017

Nature Reviews Cancer

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18 August 2017

8

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18 August 2017

2

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18 August 2017

121-132

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https://scigraph.springernature.com/pub.10.1038/nrc2297

18 August 2017

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Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

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PUMA, a novel proapoptotic gene, is induced by p53

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The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

31 March 2020

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

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Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

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Transcription-independent pro-apoptotic functions of p53.

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Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

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The multidomain proapoptotic molecules Bax and Bak are directly activated by heat

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Nonionic detergents induce dimerization among members of the Bcl-2 family

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Movement of Bax from the cytosol to mitochondria during apoptosis

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Bcl2's flexible loop domain regulates p53 binding and survival

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Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

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Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis

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A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast

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Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel

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BAX-dependent transport of cytochrome c reconstituted in pure liposomes

31 March 2020

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

31 March 2020

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Corpse clearance defines the meaning of cell death

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A receptor for phosphatidylserine-specific clearance of apoptotic cells

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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

31 March 2020

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BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

31 March 2020

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Bax-independent inhibition of apoptosis by Bcl-XL.

31 March 2020

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Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

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Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.

31 March 2020

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31 March 2020

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

31 March 2020

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At the gates of death.

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BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

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31 March 2020

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Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

31 March 2020

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Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

31 March 2020

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31 March 2020

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31 March 2020

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

31 March 2020

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BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC2297

1 reference

18 August 2017

1 reference

PubMed ID

18202696