(Q27852141)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Sevin Turcan

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Christian Grommes

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Carl Campos

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Cameron Brennan

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Thomas Graeber

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Ingo K Mellinghoff

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

author name string

Dan Rohle

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Janeta Popovici-Muller

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Jennifer Tsoi

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Owen Clark

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Barbara Oldrini

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Evangelia Komisopoulou

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Kaiko Kunii

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Alicia Pedraza

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Stefanie Schalm

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Lee Silverman

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Alexandra Miller

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Fang Wang

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Hua Yang

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Yue Chen

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Andrew Kernytsky

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Marc K Rosenblum

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Wei Liu

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Scott A Biller

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Shinsan M Su

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Timothy A Chan

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Katharine E Yen

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

language of work or name

English

0 references

publication date

4 April 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

volume

340

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

page(s)

626-630

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

issue

6132

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

28 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

Epigenetic choreographers of neurogenesis in the adult mammalian brain

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

Recurring mutations found by sequencing an acute myeloid leukemia genome

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

IDH1 and IDH2 mutations in gliomas

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

An integrated genomic analysis of human glioblastoma multiforme

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

The 2007 WHO classification of tumours of the central nervous system

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

Genome-wide atlas of gene expression in the adult mouse brain

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

Structural studies on human 2-oxoglutarate dependent oxygenases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

IDH mutation impairs histone demethylation and results in a block to cell differentiation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

A feedback loop mediated by degradation of an inhibitor is required to initiate neuronal differentiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3985613

Epidermal growth factor receptor and Ink4a/Arf

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23558169

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.1236062

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23558169%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

2 references