(Q33630257)

28 July 2017

title

Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo (English)

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28 July 2017

author name string

Janeta Popovici-Muller

1

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28 July 2017

Jeffrey O Saunders

2

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28 July 2017

Francesco G Salituro

3

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28 July 2017

Jeremy M Travins

4

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28 July 2017

Shunqi Yan

5

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28 July 2017

Fang Zhao

6

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28 July 2017

Stefan Gross

7

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28 July 2017

Lenny Dang

8

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28 July 2017

Katharine E Yen

9

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28 July 2017

Hua Yang

10

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28 July 2017

Kimberly S Straley

11

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28 July 2017

Shengfang Jin

12

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28 July 2017

Kaiko Kunii

13

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28 July 2017

Valeria R Fantin

14

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28 July 2017

Shunan Zhang

15

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28 July 2017

Qiongqun Pan

16

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28 July 2017

Derek Shi

17

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28 July 2017

Scott A Biller

18

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28 July 2017

Shinsan M Su

19

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28 July 2017

publication date

17 September 2012

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ACS Medicinal Chemistry Letters

28 July 2017

published in

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28 July 2017

volume

3

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28 July 2017

issue

10

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28 July 2017

page(s)

850-855

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IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

28 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025665

IDH mutation impairs histone demethylation and results in a block to cell differentiation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025665

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025665

IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025665

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025665

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025665

Cancer-associated IDH mutations: biomarker and therapeutic opportunities

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025665

Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025665

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025665

IDH1 and IDH2 mutations in gliomas

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025665

An integrated genomic analysis of human glioblastoma multiforme

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025665

IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025665

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4025665

30 October 2018

Identifiers

DOI

10.1021/ML300225H

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28 July 2017

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28 July 2017

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