(Q37980697)

26 August 2017

3-Bromopyruvate: targets and outcomes (English)

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26 August 2017

Maria C Shoshan

1

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26 August 2017

1 February 2012

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Journal of Bioenergetics and Biomembranes

26 August 2017

1 reference

26 August 2017

44

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26 August 2017

7-15

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26 August 2017

1

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https://scigraph.springernature.com/pub.10.1007/s10863-012-9419-2

26 August 2017

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cites work

Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy

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Targets of 3-bromopyruvate, a new, energy depleting, anticancer agent.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

3-bromopyruvate: a new targeted antiglycolytic agent and a promise for cancer therapy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase

21 January 2018

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Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP.

21 January 2018

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Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria

21 January 2018

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The pivotal roles of mitochondria in cancer: Warburg and beyond and encouraging prospects for effective therapies

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

VDAC, a multi-functional mitochondrial protein regulating cell life and death

21 January 2018

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Mitochondrial metabolism inhibitors for cancer therapy.

21 January 2018

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Hexokinase II: the integration of energy metabolism and control of apoptosis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Glycolysis inhibition for anticancer treatment

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Hallmarks of Cancer: The Next Generation

21 January 2018

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Targeting metabolic transformation for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells : ROS-mediated cell death by 3-BrPA.

21 January 2018

1 reference

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AIF deficiency compromises oxidative phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Does apoptosis-inducing factor (AIF) have both life and death functions in cells?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

AIF: not just an apoptosis-inducing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Apoptosis-inducing factor: structure, function, and redox regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Methyl jasmonate binds to and detaches mitochondria-bound hexokinase

21 January 2018

1 reference

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Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis.

21 January 2018

1 reference

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Hexokinase II detachment from the mitochondria potentiates cisplatin induced cytotoxicity through a caspase-2 dependent mechanism

21 January 2018

1 reference

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3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs

21 January 2018

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VDAC1 cysteine residues: topology and function in channel activity and apoptosis

21 January 2018

1 reference

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Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding.

21 January 2018

1 reference

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The permeability transition pore complex: another view.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

New nuclear functions of the glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase, in mammalian cells

21 January 2018

1 reference

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GAPDH as a sensor of NO stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Modification of human erythrocyte pyruvate kinase by an active site-directed reagent: bromopyruvate

21 January 2018

1 reference

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Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger

21 January 2018

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A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

21 January 2018

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Hamster sperm capacitation: role of pyruvate dehydrogenase A and dihydrolipoamide dehydrogenase

21 January 2018

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Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

3-Bromopyruvate induces necrotic cell death in sensitive melanoma cell lines

21 January 2018

1 reference

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Mitochondrial dysfunction and effect of antiglycolytic bromopyruvic acid in GL15 glioblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

The double-edged sword of autophagy modulation in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging-related processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3-bromopyruvate, iodoacetate or 5-fluorouracil

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Glycolysis inhibition inactivates ABC transporters to restore drug sensitivity in malignant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Non-invasive MRI tumor imaging and synergistic anticancer effect of HSP90 inhibitor and glycolysis inhibitor in RIP1-Tag2 transgenic pancreatic tumor model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Monocarboxylate transporters 1 and 4 are associated with CD147 in cervical carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Assessment of tumoricidal efficacy and response to treatment with 18F-FDG PET/CT after intraarterial infusion with the antiglycolytic agent 3-bromopyruvate in the VX2 model of liver tumor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Targeting of VX2 rabbit liver tumor by selective delivery of 3-bromopyruvate: a biodistribution and survival study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Local toxicity of hepatic arterial infusion of hexokinase II inhibitor, 3-bromopyruvate: In vivo investigation in normal rabbit model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Specificity of the anti-glycolytic activity of 3-bromopyruvate confirmed by FDG uptake in a rat model of breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Systemic administration of 3-bromopyruvate in treating disseminated aggressive lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Analysis of cytotoxicities of platinum compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Cisplatin impairs rat liver mitochondrial functions by inducing changes on membrane ion permeability: prevention by thiol group protecting agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Mechanisms of cisplatin-induced ototoxicity and prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Mechanisms of cisplatin ototoxicity and progress in otoprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9419-2

Escherichia coli pyruvate dehydrogenase complex. Thiamin pyrophosphate-dependent inactivation by 3-bromopyruvate

21 January 2018

1 reference

12 December 2020

Cisplatin-induced nephrotoxicity is associated with oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria

1 reference

12 December 2020

Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?

1 reference

12 December 2020

Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells

1 reference

12 December 2020

3-Bromopyruvate induces endoplasmic reticulum stress, overcomes autophagy and causes apoptosis in human HCC cell lines

1 reference

12 December 2020

Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain.

1 reference

12 December 2020

Renal and spermatozoal toxicity of alpha-bromohydrin, 3-bromolactate and 3-bromopyruvate

1 reference

12 December 2020

Manipulating tumor acidification as a cancer treatment strategy

1 reference

12 December 2020

VDAC, a multi-functional mitochondrial protein as a pharmacological target

1 reference

12 December 2020

Modification of yeast pyruvate kinase by an active site-directed reagent, bromopyruvate

1 reference

12 December 2020

Reactivity of the thiol groups of Escherichia coli phosphofructo-1-kinase

1 reference

12 December 2020

Clotrimazole and bifonazole detach hexokinase from mitochondria of melanoma cells

1 reference

12 December 2020

Involvement of alpha-cysteine-62 and beta-tryptophan-135 in human pyruvate dehydrogenase catalysis

1 reference

12 December 2020

Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells

1 reference

12 December 2020

Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production.

1 reference

12 December 2020

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

1 reference

12 December 2020

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

1 reference

12 December 2020

Metabolic targeting as an anticancer strategy: dawn of a new era?

1 reference

12 December 2020

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is pyruvylated during 3-bromopyruvate mediated cancer cell death

1 reference

12 December 2020

Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors.

1 reference

12 December 2020

Inactivation of H+-vacuolar ATPase by the energy blocker 3-bromopyruvate, a new antitumour agent

1 reference

12 December 2020

10.1007/S10863-012-9419-2

Identifiers

DOI

1 reference

26 August 2017

1 reference

PubMed ID

22298255