(Q36733720)

16 August 2017

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title

Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II. (English)

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16 August 2017

Stephen J Ralph

8

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Jiří Neužil

object named as

Jiri Neuzil

1

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author name string

Jeffrey C Dyason

2

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16 August 2017

Ruth Freeman

3

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16 August 2017

Lan-Feng Dong

4

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16 August 2017

Lubomir Prochazka

5

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16 August 2017

Xiu-Fang Wang

6

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16 August 2017

Immo Scheffler

7

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16 August 2017

publication date

1 February 2007

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Journal of Bioenergetics and Biomembranes

16 August 2017

published in

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16 August 2017

volume

39

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16 August 2017

issue

1

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16 August 2017

page(s)

65-72

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Superoxide is responsible for apoptosis in rat vascular smooth muscle cells induced by alpha-tocopheryl hemisuccinate

16 August 2017

cites work

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Crossref

https://api.crossref.org/works/10.1007%2FS10863-006-9060-Z

Mitochondrial hexokinases: guardians of the mitochondria

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10863-006-9060-Z

Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10863-006-9060-Z

Redox regulation of transcriptional activators

21 January 2018

1 reference

12 December 2020

Induction of cancer cell apoptosis by alpha-tocopheryl succinate: molecular pathways and structural requirements

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12 December 2020

Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors

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12 December 2020

Damage-induced Bax N-terminal change, translocation to mitochondria and formation of Bax dimers/complexes occur regardless of cell fate

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12 December 2020

Mitochondria play a central role in apoptosis induced by alpha-tocopheryl succinate, an agent with antineoplastic activity: comparison with receptor-mediated pro-apoptotic signaling

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12 December 2020

Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities

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12 December 2020

A Chinese Hamster Mutant Cell Line with a Defect in the Integral Membrane Protein CII-3 of Complex II of the Mitochondrial Electron Transport Chain

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12 December 2020

Mitochondrial thioredoxin system: effects of TrxR2 overexpression on redox balance, cell growth, and apoptosis

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12 December 2020

Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells

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12 December 2020

Movement of Bax from the cytosol to mitochondria during apoptosis

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12 December 2020

Mitochondria: releasing power for life and unleashing the machineries of death

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12 December 2020

Vitamin E analogues as anticancer agents: lessons from studies with alpha-tocopheryl succinate

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12 December 2020

Selective cancer cell killing by alpha-tocopheryl succinate

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12 December 2020

Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore

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12 December 2020

Apoptosis-based therapies for hematologic malignancies

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12 December 2020

Role of reactive oxygen species in the induction of apoptosis by alpha-tocopheryl succinate

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12 December 2020

Mitochondria, oxygen free radicals, disease and ageing

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12 December 2020

Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

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12 December 2020

Injected cytochrome c induces apoptosis

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12 December 2020

Mitochondrial respiratory chain disorders II: neurodegenerative disorders and nuclear gene defects

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12 December 2020

Promises and challenges of targeting Bcl-2 anti-apoptotic proteins for cancer therapy

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12 December 2020

Mitochondria as therapeutic targets for cancer chemotherapy

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12 December 2020

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

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12 December 2020

Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools

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12 December 2020

Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP.

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12 December 2020

Jasmonates: novel anticancer agents acting directly and selectively on human cancer cell mitochondria

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12 December 2020

Crystal structure of mitochondrial respiratory membrane protein complex II

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12 December 2020

High cytotoxicity of alpha-tocopheryl hemisuccinate to cancer cells is due to failure of their antioxidative defense systems

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12 December 2020

RRR-alpha-tocopheryl succinate-induced apoptosis of human breast cancer cells involves Bax translocation to mitochondria

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12 December 2020

Molecular remedy of complex I defects: rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells

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12 December 2020

Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

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12 December 2020

Role of thioredoxin-1 in apoptosis induction by alpha-tocopheryl succinate and TNF-related apoptosis-inducing ligand in mesothelioma cells

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12 December 2020

Effect of alpha-tocopherol succinate on free radical and lipid peroxidation levels in BL6 melanoma cells

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12 December 2020

Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL.

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12 December 2020

Reactive oxygen species generated from the mitochondrial electron transport chain induce cytochrome c dissociation from beef-heart submitochondrial particles via cardiolipin peroxidation. Possible role in the apoptosis

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12 December 2020

Distinct domains control the addressing and the insertion of Bax into mitochondria.

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12 December 2020

Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437.

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12 December 2020

Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production.

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12 December 2020

Defective gene expression of MnSOD in cancer cells

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12 December 2020

Mitochondriotoxic compounds for cancer therapy

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12 December 2020

PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells

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12 December 2020

Vitamin E analogues as inducers of apoptosis: structure-function relation

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12 December 2020

alpha-Tocopheryl succinate induces apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 function

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12 December 2020

Inhibition of inflammatory endothelial responses by a pathway involving caspase activation and p65 cleavage.

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12 December 2020

Alpha-tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: potential therapy of malignancies of the nervous system?

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12 December 2020

The contribution of mitochondrial respiratory complexes to the production of reactive oxygen species.

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12 December 2020

Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia.

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12 December 2020

Glycolysis inhibition for anticancer treatment

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12 December 2020

Mitochondrial tumour suppressors: a genetic and biochemical update

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12 December 2020

The Bcl2 family: regulators of the cellular life-or-death switch

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12 December 2020

Lonidamine: efficacy and safety in clinical trials for the treatment of solid tumors

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12 December 2020

Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins.

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12 December 2020

Vitamin E amides, a new class of vitamin E analogues with enhanced proapoptotic activity

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12 December 2020

Cytochrome c release from mitochondria proceeds by a two-step process

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12 December 2020

Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury

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12 December 2020

Alpha-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop: mechanism and the role of oxidative stress.

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12 December 2020

α-Tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: Implication for sensitisation of resistant cancer cells to TRAIL apoptosis

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12 December 2020

The tumor suppressor cybL, a component of the respiratory chain, mediates apoptosis induction

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12 December 2020

A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis.

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12 December 2020

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

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12 December 2020

Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53

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12 December 2020

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

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12 December 2020

Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties

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12 December 2020

BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis

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12 December 2020

A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells.

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12 December 2020

Reactive oxygen species in cancer cells: live by the sword, die by the sword.

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12 December 2020

Use of arsenic trioxide in haematological malignancies: insight into the clinical development of a novel agent

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12 December 2020

10.1007/S10863-006-9060-Z

Identifiers

DOI

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16 August 2017

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