(Q37932441)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21918915%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

review article

1 reference

title

Mitochondrial metabolism inhibitors for cancer therapy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21918915%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21918915%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Philip Hogg

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21918915%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

author name string

Pierre J Dilda

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21918915%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

publication date

15 September 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21918915%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

published in

Pharmaceutical Research

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21918915%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

volume

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21918915%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21918915%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

page(s)

2731-2744

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21918915%20AND%20SRC:MED&resulttype=core&format=json

On the Origin of Cancer Cells

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Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity

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Regulation of hexokinase binding to VDAC

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Relationship between expression of voltage-dependent anion channel (VDAC) isoforms and type of hexokinase binding sites on brain mitochondria

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies

21 January 2018

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21 January 2018

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Clotrimazole induces a late G1 cell cycle arrest and sensitizes glioblastoma cells to radiation in vitro

21 January 2018

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21 January 2018

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A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

21 January 2018

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Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation

21 January 2018

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21 January 2018

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Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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AZD7545, a novel inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2), activates pyruvate dehydrogenase in vivo and improves blood glucose control in obese (fa/fa) Zucker rats

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II.

21 January 2018

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Vitamin E and cancer: An insight into the anticancer activities of vitamin E isomers and analogs

21 January 2018

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Induction of cancer cell apoptosis by alpha-tocopheryl succinate: molecular pathways and structural requirements

21 January 2018

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Vitamin E analogues as mitochondria-targeting compounds: from the bench to the bedside?

21 January 2018

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Minerals and vitamins and the risk of bladder cancer: results from the New Hampshire Study

21 January 2018

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Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells

21 January 2018

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Inhibitory effects of benzyl isothiocyanate and benzyl thiocyanate on diethylnitrosamine-induced hepatocarcinogenesis in rats

21 January 2018

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Resveratrol: a review of preclinical studies for human cancer prevention

21 January 2018

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Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols

21 January 2018

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Inhibition of mitochondrial proton F0F1-ATPase/ATP synthase by polyphenolic phytochemicals

21 January 2018

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Modulation of apoptosis by natural products for cancer therapy

21 January 2018

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Therapeutic potential of resveratrol: the in vivo evidence

21 January 2018

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Development of mitochondria-targeted derivatives of resveratrol

21 January 2018

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Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis

21 January 2018

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Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients.

21 January 2018

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Mitochondrial ATP synthasome. Cristae-enriched membranes and a multiwell detergent screening assay yield dispersed single complexes containing the ATP synthase and carriers for Pi and ADP/ATP.

21 January 2018

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Mitochondrial ATP synthasome: three-dimensional structure by electron microscopy of the ATP synthase in complex formation with carriers for Pi and ADP/ATP.

21 January 2018

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A fourth ADP/ATP carrier isoform in man: identification, bacterial expression, functional characterization and tissue distribution

21 January 2018

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Adenine nucleotide translocase 2 is a key mitochondrial protein in cancer metabolism.

21 January 2018

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Chemosensitization by knockdown of adenine nucleotide translocase-2.

21 January 2018

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Adenine nucleotide translocase-1, a component of the permeability transition pore, can dominantly induce apoptosis

21 January 2018

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Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells.

21 January 2018

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The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cells

21 January 2018

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VDAC, a multi-functional mitochondrial protein regulating cell life and death

21 January 2018

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Characterization of human VDAC isoforms: a peculiar function for VDAC3?

21 January 2018

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The voltage-dependent anion channel-1 modulates apoptotic cell death.

21 January 2018

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Molecular and functional characterization of VDAC2 purified from mammal spermatozoa

21 January 2018

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Expression and localization of voltage-dependent anion channels (VDAC) in human spermatozoa

21 January 2018

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Bioreductive activation of quinone antitumor drugs by mitochondrial voltage-dependent anion channel 1.

21 January 2018

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Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

21 January 2018

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The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

21 January 2018

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Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier

21 January 2018

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Dynamic evolution of the adenine nucleotide translocase interactome during chemotherapy-induced apoptosis

21 January 2018

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Mitochondrial intermembrane junctional complexes and their involvement in cell death

21 January 2018

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Mitochondrial intermembrane junctional complexes and their role in cell death

21 January 2018

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A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Mitochondria as targets in angiogenesis inhibition

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Metabolism of the tumor angiogenesis inhibitor 4-(N-(S-Glutathionylacetyl)amino)phenylarsonous acid

21 January 2018

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Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains.

21 January 2018

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Optimization of the antitumor efficacy of a synthetic mitochondrial toxin by increasing the residence time in the cytosol.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

3-Bromopyruvate induces necrotic cell death in sensitive melanoma cell lines

21 January 2018

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3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate

21 January 2018

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3-bromopyruvate: a new targeted antiglycolytic agent and a promise for cancer therapy

21 January 2018

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Jasmonates--a new family of anti-cancer agents

21 January 2018

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Methyl jasmonate binds to and detaches mitochondria-bound hexokinase

21 January 2018

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Methyl jasmonate: a plant stress hormone as an anti-cancer drug

21 January 2018

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Plant stress hormones suppress the proliferation and induce apoptosis in human cancer cells

21 January 2018

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Effects of natural and novel synthetic jasmonates in experimental metastatic melanoma

21 January 2018

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A methyl jasmonate derivative, J-7, induces apoptosis in human hepatocarcinoma Hep3B cells in vitro

21 January 2018

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Betulinic Acid for cancer treatment and prevention

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21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-o-(3',3'-dimethylsuccinyl)betulinic acid (bevirimat) against human immunodeficiency virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Honokiol, a multifunctional antiangiogenic and antitumor agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Honokiol: a potent chemotherapy candidate for human colorectal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Honokiol, a natural therapeutic candidate, induces apoptosis and inhibits angiogenesis of ovarian tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Molecular architecture of native HIV-1 gp120 trimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Preparation of MPEG-PLA nanoparticle for honokiol delivery in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

All-trans-retinoic acid binds to and inhibits adenine nucleotide translocase and induces mitochondrial permeability transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Apoptosis induction by retinoids in eosinophilic leukemia cells: implication of retinoic acid receptor-alpha signaling in all-trans-retinoic acid hypersensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Acute promyelocytic leukemia: evolving therapeutic strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Fludarabine and cytosine are less effective than standard ADE chemotherapy in high-risk acute myeloid leukemia, and addition of G-CSF and ATRA are not beneficial: results of the MRC AML-HR randomized trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

The impact on outcome of the addition of all-trans retinoic acid to intensive chemotherapy in younger patients with nonacute promyelocytic acute myeloid leukemia: ...

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Arsenical-based cancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Glutaminolysis: supplying carbon or nitrogen or both for cancer cells?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Glutamine addiction: a new therapeutic target in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Targeting glutamine metabolism sensitizes melanoma cells to TRAIL-induced death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Targeting aspartate aminotransferase in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Improving cancer radiotherapy with 2-deoxy-D-glucose: phase I/II clinical trials on human cerebral gliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

All-trans retinoic acid in acute promyelocytic leukemia: long-term outcome and prognostic factor analysis from the North American Intergroup protocol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Randomized phase II trial of All-trans-retinoic acid with chemotherapy based on paclitaxel and cisplatin as first-line treatment in patients with advanced non-small-cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0584-5

Hexokinase receptor complex in hepatoma mitochondria: evidence from N,N'-dicyclohexylcarbodiimide-labeling studies for the involvement of the pore-forming protein VDAC

21 January 2018

1 reference

12 December 2020

Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?

1 reference

12 December 2020

Phase II trial of acivicin versus etoposide-cisplatin in non-small cell lung cancer. An Eastern Cooperative Oncology Group study

1 reference

12 December 2020

Hexokinase 'binding sites' of normal and tumoral human brain mitochondria

1 reference

12 December 2020

Phase I study of acivicin and cisplatin in non-small-cell lung cancer. A National Cancer Institute of Canada study.

1 reference

12 December 2020

Bullatacin--in vivo and in vitro experience in an ovarian cancer model

1 reference

12 December 2020

The bioenergetic signature of cancer: a marker of tumor progression.

1 reference

12 December 2020

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

1 reference

12 December 2020

Determination of betulinic acid in mouse blood, tumor and tissue homogenates by liquid chromatography-electrospray mass spectrometry

1 reference

12 December 2020

Over-expression of adenine nucleotide translocase 1 (ANT1) induces apoptosis and tumor regression in vivo

1 reference

12 December 2020

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

1 reference

12 December 2020

Inhibitive effect of 3-bromopyruvic acid on human breast cancer MCF-7 cells involves cell cycle arrest and apoptotic induction.

1 reference

12 December 2020

Phase II trial of acivicin in patients with advanced colorectal carcinoma

1 reference

12 December 2020

The pivotal roles of mitochondria in cancer: Warburg and beyond and encouraging prospects for effective therapies

1 reference

12 December 2020

Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase

1 reference

12 December 2020

High Km glucose-phosphorylating (glucokinase) activities in a range of tumor cell lines and inhibition of rates of tumor growth by the specific enzyme inhibitor mannoheptulose

1 reference

12 December 2020

The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid can trigger apoptosis through a mitochondrial pathway independent of the nucleus.

1 reference

12 December 2020

Glycolytic enzyme inhibitors in cancer treatment

1 reference

12 December 2020

Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc

1 reference

12 December 2020

Retinoids in cancer chemoprevention.

1 reference

12 December 2020

Rotenone induces apoptosis in MCF-7 human breast cancer cell-mediated ROS through JNK and p38 signaling

1 reference

12 December 2020

Clotrimazole and bifonazole detach hexokinase from mitochondria of melanoma cells

1 reference

12 December 2020

Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels

1 reference

12 December 2020

Impairment of the mitochondrial respiratory chain activity in diethylnitrosamine-induced rat hepatomas: possible involvement of oxygen free radicals

1 reference

12 December 2020

Two-deoxyglucose as an anti-metabolite in human carcinoma cell line RPMI-2650 and drug-resistant variants.

1 reference

12 December 2020

Effects of isothiocyanates on tumorigenesis by benzo[a]pyrene in murine tumor models

1 reference

12 December 2020

Suppression of adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells induces apoptosis and inhibits tumor growth in vitro and in vivo

1 reference

12 December 2020

Metabolic modulation of glioblastoma with dichloroacetate

1 reference

12 December 2020

Vitamin E Analogues Inhibit Angiogenesis by Selective Induction of Apoptosis in Proliferating Endothelial Cells: The Role of Oxidative Stress

1 reference

12 December 2020

Lonidamine, a selective inhibitor of aerobic glycolysis of murine tumor cells

1 reference

12 December 2020

Lung cancer: a comparative study of metabolism related protein expression in cancer cells and tumor associated stroma

1 reference

12 December 2020

Mammalian hexokinases and their abnormal expression in cancer

1 reference

12 December 2020

Phase II study of acivicin in non-small cell lung cancer: a National Cancer Institute of Canada Study

1 reference

12 December 2020

Different ways to induce apoptosis by fenretinide and all-trans-retinoic acid in human B lymphoma cells.

1 reference

12 December 2020

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is pyruvylated during 3-bromopyruvate mediated cancer cell death

1 reference

12 December 2020

Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells

1 reference

12 December 2020

Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP.

1 reference

12 December 2020

Phase II study of acivicin in colorectal carcinoma: a National Cancer Institute of Canada study

1 reference

12 December 2020

Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling

1 reference

12 December 2020