(Q47739695)

5 February 2018

title

Up-regulation of glycohydrolases in Alzheimer's Disease fibroblasts correlates with Ras activation (English)

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5 February 2018

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1

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Lorena Urbanelli

2

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5 February 2018

Antonio Orlacchio

object named as

Antonio Orlacchio

4

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Sandro Sorbi

object named as

Sandro Sorbi

6

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author name string

Leda Racanicchi

3

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5 February 2018

Giuliana Pelicci

5

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5 February 2018

Giorgio Bernardi

7

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5 February 2018

Aldo Orlacchio

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5 February 2018

language of work or name

English

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publication date

23 July 2003

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5 February 2018

Journal of Biological Chemistry

published in

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5 February 2018

volume

278

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5 February 2018

issue

40

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5 February 2018

page(s)

38453-38460

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5 February 2018

Alzheimer's disease is a synaptic failure

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Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system

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Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis

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The role of the protein glycosylation state in the control of cellular transport of the amyloid beta precursor protein

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Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration

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Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis.

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PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

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Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease

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Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

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Partial sequence of the purified protein confirms the identity of cDNA coding for human lysosomal alpha-mannosidase B.

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A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

21 January 2018

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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

21 January 2018

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A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

21 January 2018

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21 January 2018

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21 January 2018

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Inhibitors of p38 mitogen-activated protein kinase promote neuronal survival in vitro

21 January 2018

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Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease

21 January 2018

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Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in

21 January 2018

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Molecular regulation, membrane association and secretion of tumor cathepsin B.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M303030200

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5 February 2018

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5 February 2018