(Q47842376)

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The Fe2+-mediated decomposition, PfATP6 binding, and antimalarial activities of artemisone and other artemisinins: the unlikelihood of C-centered radicals as bioactive intermediates

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Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/17768732

The Fe2+-mediated decomposition, PfATP6 binding, and antimalarial activities of artemisone and other artemisinins: the unlikelihood of C-centered radicals as bioactive intermediates (English)

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Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/17768732

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Sanjeev Krishna

9

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/17768732

Donatella Taramelli

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Donatella Taramelli

6

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Richard K Haynes

object named as

Richard K Haynes

1

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Wing Chi Chan

2

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/17768732

Chung-Man Lung

3

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/17768732

Anne-Catrin Uhlemann

4

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/17768732

Ursula Eckstein

5

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/17768732

Silvia Parapini

7

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/17768732

Diego Monti

8

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Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/17768732

publication date

1 October 2007

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Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/17768732

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/17768732

2

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/17768732

10

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/17768732

1480-1497

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/17768732

From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements

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Artemisinin and derivatives: the future for malaria treatment?

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Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu).

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21 January 2018

Qinghaosu (artemisinin): an antimalarial drug from China

1 reference

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The chemistry, pharmacology, and clinical applications of qinghaosu (artemisinin) and its derivatives

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C-10 Ester and Ether Derivatives of Dihydroartemisinin − 10-α Artesunate, Preparation of Authentic 10-β Artesunate, and of Other Ester and Ether Derivatives Bearing Potential Aromatic Intercalating Groups at C-10

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7 January 2021

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Antimalarial drug resistance

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7 January 2021

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Antimalarial combinations

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Interaction of Qinghaosu (Artemisinin) with Cysteine Sulfhydryl Mediated by Traces of Non-Heme Iron

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7 January 2021

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A medicinal chemistry perspective on artemisinin and related endoperoxides

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7 January 2021

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Artemisinins: mechanisms of action and potential for resistance

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7 January 2021

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Artemisinins: activities and actions

1 reference

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7 January 2021

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EPR evidence for the involvement of free radicals in the iron-catalysed decomposition of qinghaosu (artemisinin) and some derivatives; antimalarial action of some polycyclic endoperoxides

1 reference

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7 January 2021

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Artemisinin, an Endoperoxide Antimalarial, Disrupts the Hemoglobin Catabolism and Heme Detoxification Systems in Malarial Parasite

1 reference

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Heme-artemisinin adducts are crucial mediators of the ability of artemisinin to inhibit heme polymerization

1 reference

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7 January 2021

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Reaction of artemisinin with haemoglobin: implications for antimalarial activity

1 reference

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7 January 2021

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From mechanistic studies on artemisinin derivatives to new modular antimalarial drugs

1 reference

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7 January 2021

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The behaviour of qinghaosu (artemisinin) in the presence of heme iron(II) and (III)

1 reference

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7 January 2021

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The behaviour of qinghaosu (artemisinin) in the presence of non-heme iron(II) and (III)

1 reference

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7 January 2021

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Kinetics of iron-mediated artemisinin degradation: effect of solvent composition and iron salt

1 reference

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7 January 2021

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Grapefruit juice increases the bioavailability of artemether

1 reference

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7 January 2021

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A semiphysiological pharmacokinetic model for artemisinin in healthy subjects incorporating autoinduction of metabolism and saturable first-pass hepatic extraction

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700108

7 January 2021

based on heuristic

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Alkylation of heme by the antimalarial drug artemisinin

1 reference

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7 January 2021

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Reply to Comments on ?Highly Antimalaria-Active Artemisinin Derivatives: Biological Activity Does Not Correlate with Chemical Reactivity?

1 reference

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7 January 2021

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Effects of antimalarials and protease inhibitors on plasmodial hemozoin production

1 reference

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7 January 2021

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Re-evaluation of how artemisinins work in light of emerging evidence of in vitro resistance

1 reference

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7 January 2021

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Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation

1 reference

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7 January 2021

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The antimalarial drug artemisinin alkylates heme in infected mice

1 reference

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7 January 2021

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Membrane heme as a host factor in reducing effectiveness of dihydroartemisinin

1 reference

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7 January 2021

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Artemisinin effectiveness in erythrocytes is reduced by heme and heme-containing proteins

1 reference

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7 January 2021

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Iron chelators as antimalarial agents: in vitro activity of dicatecholate against Plasmodium falciparum

1 reference

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7 January 2021

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Iron chelation therapy for malaria: a review

1 reference

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7 January 2021

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Antimalarial effect of iron chelators

1 reference

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7 January 2021

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Iron chelators: correlation between effects on Plasmodium spp. and immune functions.

1 reference

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7 January 2021

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Microsomal reduction of low-molecular-weight Fe3+ chelates and ferritin: enhancement by adriamycin, paraquat, menadione, and anthraquinone 2-sulfonate and inhibition by oxygen

1 reference

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7 January 2021

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Reduction of iron by extracellular iron reductases: implications for microbial iron acquisition

1 reference

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7 January 2021

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Ternary complex formation facilitates a redox mechanism for iron release from a siderophore.

1 reference

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7 January 2021

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Prooxidant Activity of Ferrioxamine in Isolated Rat Hepatocytes and Linoleic Acid Micelles

1 reference

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7 January 2021

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Intracellular iron, but not copper, plays a critical role in hydrogen peroxide-induced DNA damage.

1 reference

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7 January 2021

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Antioxidant and free radical scavenging activities of the iron chelators pyoverdin and hydroxypyrid-4-ones in iron-loaded hepatocyte cultures: comparison of their mechanism of protection with that of desferrioxamine

1 reference

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Toxicity of certain products of lipid peroxidation to the human malaria parasite Plasmodium falciparum

1 reference

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Characterization of the Alkylation Product of Heme by the Antimalarial Drug Artemisinin We are grateful to the CNRS for financial support, and to the French Ministery of Education for a PhD grant to J.C. Dr. Yannick Coppel (LCC-CNRS) is gratefully a

1 reference

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Deferoxamine: stimulation of hematin polymerization and antagonism of its inhibition by chloroquine

1 reference

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7 January 2021

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Food restriction and stimulation of monooxygenation of p-nitroanisole in perfused rat liver

1 reference

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7 January 2021

based on heuristic

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Possible modes of action of the artemisinin-type compounds.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Highly Antimalaria-Active Artemisinin Derivatives: Biological Activity Does Not Correlate with Chemical Reactivity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700108

7 January 2021

based on heuristic

inferred from DOI database lookup

C10-modified artemisinin derivatives: efficient heme-alkylating agents

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Artemisinins target the SERCA of Plasmodium falciparum

1 reference

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7 January 2021

based on heuristic

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A single amino acid residue can determine the sensitivity of SERCAs to artemisinins

1 reference

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7 January 2021

based on heuristic

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Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Artemisone--a highly active antimalarial drug of the artemisinin class

1 reference

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7 January 2021

based on heuristic

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Identification of an antimalarial synthetic trioxolane drug development candidate

1 reference

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7 January 2021

based on heuristic

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Dispiro-1,2,4-trioxane analogues of a prototype dispiro-1,2,4-trioxolane: mechanistic comparators for artemisinin in the context of reaction pathways with iron(II).

1 reference

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7 January 2021

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In vitro sensitivity of artemeter in Plasmodium falciparum-infected beta-thalassaemic trait erythrocytes

1 reference

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7 January 2021

based on heuristic

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Ascorbate-mediated iron release from ferritin in the presence of alloxan

1 reference

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7 January 2021

based on heuristic

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Structure-activity relationships of the antimalarial agent artemisinin. 3. Total synthesis of (+)-13-carbaartemisinin and related tetra- and tricyclic structures.

1 reference

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7 January 2021

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Artesunate and dihydroartemisinin (DHA): unusual decomposition products formed under mild conditions and comments on the fitness of DHA as an antimalarial drug

1 reference

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7 January 2021

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Expression and functional characterization of a Plasmodium falciparum Ca2+-ATPase (PfATP4) belonging to a subclass unique to apicomplexan organisms

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Carrier-mediated partitioning of artemisinin into Plasmodium falciparum-infected erythrocytes

1 reference

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7 January 2021

based on heuristic

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Ring opening of artemisinin (qinghaosu) and dihydroartemisinin and interception of the open hydroperoxides with Formation of N-oxides — a chemical model for antimalarial mode of action

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700108

7 January 2021

based on heuristic

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Synthesis of ethyl 5-phenyl-6-oxa-1-azabicyclo[3.1.0]hexane-2-carboxylate derivatives and evaluation of their antimalarial activities

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700108

7 January 2021

based on heuristic

inferred from DOI database lookup

Intracellular and extracellular labile iron pools.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700108

7 January 2021

based on heuristic

inferred from DOI database lookup

The labile iron pool: characterization, measurement, and participation in cellular processes(1).

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700108

7 January 2021

based on heuristic

inferred from DOI database lookup

Chemical aspects of siderophore mediated iron transport

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Bacterial iron homeostasis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700108

7 January 2021

based on heuristic

inferred from DOI database lookup

Factors affecting DNA damage caused by lipid hydroperoxides and aldehydes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700108

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxidants, oxidant drugs, and malaria

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700108

7 January 2021

based on heuristic

inferred from DOI database lookup

Free oxygen radical generators as antimalarial drugs

1 reference

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7 January 2021

based on heuristic

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

H2O2-induced changes in mitochondrial activity in isolated mouse pancreatic acinar cells.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700108

7 January 2021

based on heuristic

inferred from DOI database lookup

Apoptosis of human umbilical vein endothelial cells induced by artesunate

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700108

7 January 2021

based on heuristic

inferred from DOI database lookup

Of malaria, metabolism and membrane transport

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700108

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277).

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700108

7 January 2021

based on heuristic

inferred from DOI database lookup

Tetraoxane antimalarials and their reaction with Fe(II).

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700108

7 January 2021

based on heuristic

inferred from DOI database lookup

Superoxide does react with peroxides: direct observation of the Haber-Weiss reaction in the gas phase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700108

7 January 2021

based on heuristic

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Disulfide-Reductase Inhibitors as Chemotherapeutic Agents: The Design of Drugs for Trypanosomiasis and Malaria

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Antiplasmodial activity of nitroaromatic and quinoidal compounds: redox potential vs. inhibition of erythrocyte glutathione reductase.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700108

7 January 2021

based on heuristic

inferred from DOI database lookup

Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malaria-causing plasmodia

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700108

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxidative stress in malaria; implications for prevention and therapy

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Novel antitumor artemisinin derivatives targeting G1 phase of the cell cycle

1 reference

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7 January 2021

based on heuristic

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Mechanistic perspectives for 1,2,4-trioxanes in anti-cancer therapy.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Iron toxicity in organotypic cultures of hippocampal slices: role of reactive oxygen species

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700108

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of artemisinin-tagged holotransferrin on cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700108

7 January 2021

based on heuristic

inferred from DOI database lookup

Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700108

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Intraerythrocytic Plasmodium falciparum expresses a high affinity facilitative hexose transporter

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/CMDC.200700108

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/17768732

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 February 2018

http://europepmc.org/abstract/MED/17768732

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