(Q47925510)

6 February 2018

title

The triterpene cyclase protein family: a systematic analysis (English)

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6 February 2018

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4

Jürgen Pleiss

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6 February 2018

author name string

Silvia Racolta

series ordinal

1

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6 February 2018

P Benjamin Juhl

series ordinal

2

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6 February 2018

Demet Sirim

series ordinal

3

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6 February 2018

language of work or name

English

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publication date

15 May 2012

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6 February 2018

published in

Proteins

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6 February 2018

volume

80

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6 February 2018

issue

8

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6 February 2018

page(s)

2009-2019

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6 February 2018

Structural biology and chemistry of the terpenoid cyclases

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Isoprenoid biosynthesis: manifold chemistry catalyzed by similar enzymes

21 January 2018

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Phylogenetic analysis of the triterpene cyclase protein family in prokaryotes and eukaryotes suggests bidirectional lateral gene transfer

21 January 2018

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Structure and function of a squalene cyclase

21 January 2018

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Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase

21 January 2018

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Enzymatic synthesis of cyclic triterpenes

21 January 2018

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21 January 2018

Squalene-hopene cyclases

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A specific amino acid repeat in squalene and oxidosqualene cyclases

21 January 2018

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Enzymatic cyclization reactions of geraniol, farnesol and geranylgeraniol, and those of truncated squalene analogs having C20 and C25 by recombinant squalene cyclase

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24089

Cloning, expression, and sequencing of squalene-hopene cyclase, a key enzyme in triterpenoid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Comparative sequence analyses on the 16S rRNA (rDNA) of Bacillus acidocaldarius, Bacillus acidoterrestris, and Bacillus cycloheptanicus and proposal for creation of a new genus, Alicyclobacillus gen. nov.

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24089

Cloning of conserved genes from Zymomonas mobilis and Bradyrhizobium japonicum that function in the biosynthesis of hopanoid lipids

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24089

Squalene-hopene cyclase from Methylococcus capsulatus (Bath): a bacterium producing hopanoids and steroids

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24089

Zymomonas mobilis squalene-hopene cyclase gene (shc): cloning, DNA sequence analysis, and expression in Escherichia coli

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24089

Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase: a chemistry-biology interdisciplinary study of the protein's structure-function-reaction mechanism relationships

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24089

Methyl jasmonate induced accumulation of kalopanaxsaponin I in Nigella sativa

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24089

Mutagenesis approaches to deduce structure-function relationships in terpene synthases

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24089

Farnesyloxycoumarins, a new class of squalene-hopene cyclase inhibitors.

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24089

Molecular cloning, characterization, and functional expression of rat oxidosqualene cyclase cDNA

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24089

Studies on the Substrate Binding Segments and Catalytic Action of Lanosterol Synthase. Affinity Labeling with Carbocations Derived from Mechanism-Based Analogs of 2,3-Oxidosqualene and Site-Directed Mutagenesis Probes

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24089

The Lipase Engineering Database: a navigation and analysis tool for protein families

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24089

The Medium-Chain Dehydrogenase/reductase Engineering Database: a systematic analysis of a diverse protein family to understand sequence-structure-function relationship

21 January 2018

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The cytochrome P450 engineering database: Integration of biochemical properties

21 January 2018

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Rational design of a minimal and highly enriched CYP102A1 mutant library with improved regio-, stereo- and chemoselectivity

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24089

DWARF--a data warehouse system for analyzing protein families.

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24089

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24089

21 January 2018

The Protein Data Bank

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https://api.crossref.org/works/10.1002%2FPROT.24089

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24089

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

EMBOSS: the European Molecular Biology Open Software Suite

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Conversion of squalene to the pentacarbocyclic hopene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Automated analysis of interatomic contacts in proteins

21 January 2018

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https://api.crossref.org/works/10.1002%2FPROT.24089

Legumes symbioses: absence of Nod genes in photosynthetic bradyrhizobia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Squalene cyclase and oxidosqualene cyclase from a fern.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Dammaradiene synthase, a squalene cyclase, from Dryopteris crassirhizoma Nakai

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Cloning and heterologous expression of the Trypanosoma brucei lanosterol synthase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Molecular cloning, expression, and site-directed mutations of oxidosqualene cyclase from Cephalosporium caerulens

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Subcellular localization of oxidosqualene cyclases from Arabidopsis thaliana, Trypanosoma cruzi, and Pneumocystis carinii expressed in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Molecular cloning, characterization, and overexpression of ERG7, the Saccharomyces cerevisiae gene encoding lanosterol synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Isolation and characterization of the gene encoding 2,3-oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Modified oxidosqualene cyclases in the formation of bioactive secondary metabolites: biosynthesis of the antitumor clavaric acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Molecular cloning of cDNA encoding rat 2,3-oxidosqualene: lanosterol cyclase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Isolation of an Arabidopsis thaliana gene encoding cycloartenol synthase by functional expression in a yeast mutant lacking lanosterol synthase by the use of a chromatographic screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Oxidosqualene Cyclases from Cell Suspension Cultures of Betula platyphylla var. japonica: Molecular Evolution of Oxidosqualene Cyclases in Higher Plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Cloning and characterization of a lupeol synthase involved in the synthesis of epicuticular wax crystals on stem and hypocotyl surfaces of Ricinus communis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Lanosterol biosynthesis in plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Plant lanosterol synthase: divergence of the sterol and triterpene biosynthetic pathways in eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

A new triterpene synthase from Arabidopsis thaliana produces a tricyclic triterpene with two hydroxyl groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Cloning and characterization of the Arabidopsis thaliana lupeol synthase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Squalene-hopene cyclase: catalytic mechanism and substrate recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Catalytic function of the residues of phenylalanine and tyrosine conserved in squalene-hopene cyclases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Kinetic studies on the function of all the conserved tryptophans involved inside and outside the QW motifs of squalene-hopene cyclase: stabilizing effect of the protein structure against thermal denaturation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Overexpression of squalene-hopene cyclase by the pET vector in Escherichia coli and first identification of tryptophan and aspartic acid residues inside the QW motif as active sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Cation-pi interaction in the polyolefin cyclization cascade uncovered by incorporating unnatural amino acids into the catalytic sites of squalene cyclase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Synthesis and biological activity of new iodoacetamide derivatives on mutants of squalene-hopene cyclase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Thiol-modifying inhibitors for understanding squalene cyclase function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Functional analyses of Tyr420 and Leu607 of Alicyclobacillus acidocaldarius squalene-hopene cyclase. Neoachillapentaene, a novel triterpene with the 1,5,6-trimethylcyclohexene moiety produced through folding of the constrained boat structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Bicyclic triterpenes as new main products of squalene-hopene cyclase by mutation at conserved tyrosine residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Molecular cloning of a Schizosaccharomyces pombe cDNA encoding lanosterol synthase and investigation of conserved tryptophan residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Steric bulk at position 454 in Saccharomyces cerevisiae lanosterol synthase influences B-ring formation but not deprotonation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Enzymatic formation of multiple triterpenes by mutation of tyrosine 510 of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Access of the substrate to the active site of yeast oxidosqualene cyclase: an inhibition and site-directed mutagenesis approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Alteration of the substrate's prefolded conformation and cyclization stereochemistry of oxidosqualene-lanosterol cyclase of Saccharomyces cerevisiae by substitution at phenylalanine 699.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Importance of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase tyrosine 707 residue for chair-boat bicyclic ring formation and deprotonation reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Enzyme redesign: two mutations cooperate to convert cycloartenol synthase into an accurate lanosterol synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Conversion of a plant oxidosqualene-cycloartenol synthase to an oxidosqualene-lanosterol cyclase by random mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Activation-independent cyclization of monoterpenoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Structural diversity of the triterpenic hydrocarbons from the bacterium Zymomonas mobilis: the signature of defective squalene cyclization by the squalene/hopene cyclase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Improved genome annotation for Zymomonas mobilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

Directed evolution experiments reveal mutations at cycloartenol synthase residue His477 that dramatically alter catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24089

21 January 2018

Identifiers

DOI

10.1002/PROT.24089

1 reference

6 February 2018

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6 February 2018