(Q47963712)

7 February 2018

title

Inhibiting polymerization: new therapeutic strategies for Z alpha1-antitrypsin-related emphysema (English)

1 reference

7 February 2018

author

Tim Dafforn

2

1 reference

7 February 2018

author name string

Helen Parfrey

1

1 reference

7 February 2018

Didier Belorgey

3

1 reference

7 February 2018

David A Lomas

4

1 reference

7 February 2018

Ravi Mahadeva

5

1 reference

7 February 2018

publication date

11 March 2004

1 reference

7 February 2018

American Journal of Respiratory Cell and Molecular Biology

published in

1 reference

7 February 2018

volume

31

1 reference

7 February 2018

issue

2

1 reference

7 February 2018

page(s)

133-139

1 reference

7 February 2018

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

cites work

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

Structural basis for serpin inhibitor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

Human alpha 1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 A and full insertion of the reactive center loop into beta-sheet A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

Structure of a serpin-protease complex shows inhibition by deformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

The mechanism of Z alpha 1-antitrypsin accumulation in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

Familial dementia caused by polymerization of mutant neuroserpin

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp)

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

Alpha1-antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

6-mer peptide selectively anneals to a pathogenic serpin conformation and blocks polymerization. Implications for the prevention of Z alpha(1)-antitrypsin-related cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

Mutations which impede loop/sheet polymerization enhance the secretion of human alpha 1-antitrypsin deficiency variants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

Structural transition of alpha 1-antitrypsin by a peptide sequentially similar to beta-strand s4A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

Probing serpin reactive-loop conformations by proteolytic cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

Inhibition of human pancreatic proteinases by mucus proteinase inhibitor, eglin c and aprotinin

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

Biological implications of a 3 A structure of dimeric antithrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

Polymerization of plasminogen activator inhibitor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

Peptide-based targeting of fluorophores to organelles in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

Pathogenic α1-Antitrypsin Polymers Are Formed by Reactive Loop-β-Sheet A Linkage

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

A Kinetic Mechanism for the Polymerization of α1-Antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

Structural insights into serpin-protease complexes reveal the inhibitory mechanism of serpins

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

Theoretical and practical aspects of proteinase inhibition kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2003-0276OC

21 January 2018

Identifiers

DOI

10.1165/RCMB.2003-0276OC

1 reference

7 February 2018

1 reference

7 February 2018