(Q48020552)

7 February 2018

title

Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognition (English)

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7 February 2018

author

Xiaohai Wang

4

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7 February 2018

Christopher Winrow

20

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7 February 2018

author name string

Jason M Uslaner

1

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7 February 2018

Spencer J Tye

2

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7 February 2018

Donnie M Eddins

3

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7 February 2018

Steven V Fox

5

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7 February 2018

Alan T Savitz

6

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7 February 2018

Jacquelyn Binns

7

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7 February 2018

Christopher E Cannon

8

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7 February 2018

Susan L Garson

9

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7 February 2018

Lihang Yao

10

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7 February 2018

Robert Hodgson

11

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7 February 2018

Joanne Stevens

12

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7 February 2018

Mark R Bowlby

13

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7 February 2018

Pamela L Tannenbaum

14

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7 February 2018

Joseph Brunner

15

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7 February 2018

Terrence P Mcdonald

16

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7 February 2018

Anthony L Gotter

17

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7 February 2018

Scott D Kuduk

18

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7 February 2018

Paul J Coleman

19

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7 February 2018

John J Renger

21

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7 February 2018

language of work or name

English

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publication date

1 April 2013

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7 February 2018

Science Translational Medicine

published in

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7 February 2018

volume

5

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7 February 2018

issue

179

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7 February 2018

page(s)

179ra44

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7 February 2018

Prevalence of DSM-IV diagnostic criteria of insomnia: distinguishing insomnia related to mental disorders from sleep disorders.

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Residual effects of middle-of-the-night administration of zaleplon and zolpidem on driving ability, memory functions, and psychomotor performance

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Orexin receptors: pharmacology and therapeutic opportunities

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Discovery of a potent, CNS-penetrant orexin receptor antagonist based on an n,n-disubstituted-1,4-diazepane scaffold that promotes sleep in rats.

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Promotion of sleep by suvorexant-a novel dual orexin receptor antagonist

21 January 2018

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Phase I studies on the safety, tolerability, pharmacokinetics and pharmacodynamics of SB-649868, a novel dual orexin receptor antagonist

21 January 2018

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Differential effects of a dual orexin receptor antagonist (SB-649868) and zolpidem on sleep initiation and consolidation, SWS, REM sleep, and EEG power spectra in a model of situational insomnia

21 January 2018

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The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity

21 January 2018

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Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

21 January 2018

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Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties.

21 January 2018

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Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles.

21 January 2018

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Effects of daytime administration of zolpidem versus triazolam on memory

21 January 2018

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Comparative effects of zopiclone, triazolam and placebo on memory and psychomotor performance in healthy volunteers

21 January 2018

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Actions of zopiclone and carbamazepine, alone and in combination, on human skilled performance in laboratory and clinical tests

21 January 2018

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Comparison of the daytime sleep and performance effects of zolpidem versus triazolam

21 January 2018

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Comparative study of the effects of zopiclone (7.5 mg), zolpidem, flunitrazepam and a placebo on nocturnal cognitive performance in healthy subjects, in relation to pharmacokinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005213

Highway driving performance and cognitive functioning the morning after bedtime and middle-of-the-night use of gaboxadol, zopiclone and zolpidem.

21 January 2018

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Sedative, memory, and performance effects of hypnotics.

21 January 2018

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Zolpidem, triazolam, and temazepam: behavioral and subject-rated effects in normal volunteers.

21 January 2018

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Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.

21 January 2018

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Bidirectional effects of benzodiazepine binding site ligands on active avoidance acquisition and retention: differential antagonism by flumazenil and beta-CCt

21 January 2018

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The alpha1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala

21 January 2018

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21 January 2018

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21 January 2018

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International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update

21 January 2018

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Diazepam-induced changes in sleep: role of the alpha 1 GABA(A) receptor subtype

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Measurement of GABAergic parameters in the prefrontal cortex in schizophrenia: focus on GABA content, GABA(A) receptor alpha-1 subunit messenger RNA and human GABA transporter-1 (HGAT-1) messenger RNA expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005213

Differential expression of orexin receptors 1 and 2 in the rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005213

Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005213

Promotion of sleep by targeting the orexin system in rats, dogs and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005213

Functional inactivation of orexin 1 receptors in CA1 region impairs acquisition, consolidation and retrieval in Morris water maze task.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005213

The selective orexin 1 receptor antagonist SB-334867-A impairs acquisition and consolidation but not retrieval of spatial memory in Morris water maze.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005213

The effect of antagonization of orexin 1 receptors in CA1 and dentate gyrus regions on memory processing in passive avoidance task.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005213

Systemic and intrabasalis administration of the orexin-1 receptor antagonist, SB-334867, disrupts attentional performance in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005213

Stimulation of cortical acetylcholine release by orexin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005213

Hypocretin/orexin innervation and excitation of identified septohippocampal cholinergic neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005213

The action of orexin A on passive avoidance learning. Involvement of transmitters

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005213

Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005213

Orexin-A (hypocretin-1) impairs Morris water maze performance and CA1-Schaffer collateral long-term potentiation in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005213

Orexin receptor antagonism, a new sleep-promoting paradigm: an ascending single-dose study with almorexant

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005213

Sub-chronic administration of zolpidem affects modifications to rat sleep architecture

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005213

The pharmacology and mechanisms of action of new generation, non-benzodiazepine hypnotic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005213

10.1126/SCITRANSLMED.3005213

21 January 2018

Identifiers

DOI

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7 February 2018

1 reference

7 February 2018