(Q48260151)

English

Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/22307992

Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties (English)

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/22307992

Christopher Winrow

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10 February 2018

http://europepmc.org/abstract/MED/22307992

author name string

Paul J Coleman

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10 February 2018

http://europepmc.org/abstract/MED/22307992

John D Schreier

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http://europepmc.org/abstract/MED/22307992

Christopher D Cox

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http://europepmc.org/abstract/MED/22307992

Michael J Breslin

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http://europepmc.org/abstract/MED/22307992

David B Whitman

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http://europepmc.org/abstract/MED/22307992

Michael J Bogusky

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http://europepmc.org/abstract/MED/22307992

Georgia B McGaughey

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http://europepmc.org/abstract/MED/22307992

Rodney A Bednar

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http://europepmc.org/abstract/MED/22307992

Wei Lemaire

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http://europepmc.org/abstract/MED/22307992

Scott M Doran

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http://europepmc.org/abstract/MED/22307992

Steven V Fox

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http://europepmc.org/abstract/MED/22307992

Susan L Garson

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http://europepmc.org/abstract/MED/22307992

Anthony L Gotter

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http://europepmc.org/abstract/MED/22307992

C Meacham Harrell

14

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http://europepmc.org/abstract/MED/22307992

Duane R Reiss

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http://europepmc.org/abstract/MED/22307992

Tamara D Cabalu

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http://europepmc.org/abstract/MED/22307992

Donghui Cui

17

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http://europepmc.org/abstract/MED/22307992

Thomayant Prueksaritanont

18

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http://europepmc.org/abstract/MED/22307992

Joanne Stevens

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http://europepmc.org/abstract/MED/22307992

Pamela L Tannenbaum

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http://europepmc.org/abstract/MED/22307992

Richard G Ball

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http://europepmc.org/abstract/MED/22307992

Joyce Stellabott

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http://europepmc.org/abstract/MED/22307992

Steven D Young

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http://europepmc.org/abstract/MED/22307992

George D Hartman

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http://europepmc.org/abstract/MED/22307992

John J Renger

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http://europepmc.org/abstract/MED/22307992

publication date

3 February 2012

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http://europepmc.org/abstract/MED/22307992

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http://europepmc.org/abstract/MED/22307992

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415-24, 337

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10 February 2018

http://europepmc.org/abstract/MED/22307992

Diagnosis and treatment of chronic insomnia: a review

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Insomnia in the elderly: cause, approach, and treatment

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Insomnia causes, consequences, and therapeutics: an overview.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Comparative tolerability of newer agents for insomnia

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Reduced number of hypocretin neurons in human narcolepsy

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Diurnal variation in CSF orexin-A in healthy male subjects.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Effects of IV and ICV hypocretin-1 (orexin A) in hypocretin receptor-2 gene mutated narcoleptic dogs and IV hypocretin-1 replacement therapy in a hypocretin-ligand-deficient narcoleptic dog.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Promotion of sleep by suvorexant-a novel dual orexin receptor antagonist

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Orexin receptors: pharmacology and therapeutic opportunities

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Orexin receptor antagonists: a new concept in CNS disorders?

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Orexin receptor antagonists: a review of promising compounds patented since 2006.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Discovery of a potent, CNS-penetrant orexin receptor antagonist based on an n,n-disubstituted-1,4-diazepane scaffold that promotes sleep in rats.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Promotion of sleep by targeting the orexin system in rats, dogs and humans

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Discovery of dual orexin receptor antagonists (DORAs) for the treatment of insomnia

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Allylic strain in six-membered rings

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Conformational analysis of N,N-disubstituted-1,4-diazepane orexin receptor antagonists and implications for receptor binding

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

A short history of SHELX

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200025

21 January 2018

Identifiers

10.1002/CMDC.201200025

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/22307992

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/22307992

ResearchGate publication ID

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