(Q48024052)

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Efficient methylation of C2 in l-tryptophan by the cobalamin-dependent radical S-adenosylmethionine methylase TsrM requires an unmodified N1 amine.

scientific article published on 26 July 2017

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scholarly article

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26 March 2020

Efficient methylation of C2 in l-tryptophan by the cobalamin-dependent radical S-adenosylmethionine methylase TsrM requires an unmodified N1 amine (English)

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26 March 2020

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26 March 2020

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26 March 2020

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Anthony J Blaszczyk

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26 March 2020

Bo Wang

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26 March 2020

Jackson V Ho

4

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26 March 2020

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26 July 2017

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26 March 2020

Journal of Biological Chemistry

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26 March 2020

292

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26 March 2020

15456-15467

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26 March 2020

37

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26 March 2020

A B12-dependent radical SAM enzyme involved in oxetanocin A biosynthesis

1 reference

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The thiostrepton A tryptophan methyltransferase TsrM catalyses a cob(II)alamin-dependent methyl transfer reaction

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Consecutive radical S-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis

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Mechanistic diversity of radical S-adenosylmethionine (SAM)-dependent methylation

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Initial characterization of Fom3 from Streptomyces wedmorensis: The methyltransferase in fosfomycin biosynthesis

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GenK-catalyzed C-6' methylation in the biosynthesis of gentamicin: isolation and characterization of a cobalamin-dependent radical SAM enzyme.

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A substrate radical intermediate in catalysis by the antibiotic resistance protein Cfr.

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Thiostrepton tryptophan methyltransferase expands the chemistry of radical SAM enzymes.

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RlmN and AtsB as models for the overproduction and characterization of radical SAM proteins.

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Cytochrome P450–catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis

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26 August 2018

Radical-mediated enzymatic methylation: a tale of two SAMS

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26 August 2018

Hydrogen bonding of tryptophan radicals revealed by EPR at 700 GHz

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In vitro phosphinate methylation by PhpK from Kitasatospora phosalacinea

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26 August 2018

Recent advances in thiopeptide antibiotic biosynthesis

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Stereocontrolled and efficient total synthesis of (-)-stephanotic acid methyl ester and (-)-celogentin C.

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Thiostrepton biosynthesis: prototype for a new family of bacteriocins

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Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications

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Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression

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Tryptophan synthase: the workings of a channeling nanomachine

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From amino acids to heteroaromatics--thiopeptide antibiotics, nature's heterocyclic peptides

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A new paradigm for electrostatic catalysis of radical reactions in vitamin B12 enzymes

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Thiopeptide antibiotics

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Measurement of energetics of conformational change in cobalamin-dependent methionine synthase.

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Radical mechanisms of S-adenosylmethionine-dependent enzymes

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Spectroscopic and Electrochemical Characterization of the Iron–Sulfur and Cobalamin Cofactors of TsrM, an Unusual Radical S-Adenosylmethionine Methylase

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Nucleophilic reactivities of indoles

1 reference

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Role of S-Adenosylmethionine in Vitamin B12-dependent Methionine Synthesis

1 reference

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1 reference

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1 reference

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12 December 2020

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Methylcobalamin's full- vs. "half"-strength cobalt-carbon sigma bonds and bond dissociation enthalpies: A >10(15) Co-CH3 homolysis rate enhancement following one-antibonding-electron reduction of methlycobalamin

1 reference

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inferred from PubMed ID database lookup

Role of the [4Fe-4S] cluster in reductive activation of the cobalt center of the corrinoid iron-sulfur protein from Clostridium thermoaceticum during acetate biosynthesis

1 reference

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Hypersensitive radical probes and the mechanisms of cytochrome P450-catalyzed hydroxylation reactions

1 reference

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based on heuristic

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Identifiers

10.1074/JBC.M117.778548

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28747433%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

1 reference

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26 March 2020

1 reference

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26 March 2020

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