(Q48029737)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27872186%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

title

The Interplay between Calmodulin and Membrane Interactions with the Pleckstrin Homology Domain of Akt (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27872186%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27872186%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

author name string

Constance Agamasu

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27872186%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

Ruba H Ghanam

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27872186%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

Fei Xu

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27872186%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

Yong Sun

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27872186%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

Yabing Chen

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27872186%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

language of work or name

English

0 references

publication date

21 November 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27872186%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

27 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27872186%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

volume

292

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27872186%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27872186%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

page(s)

251-263

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27872186%20AND%20SRC:MED&resulttype=core&format=json

Structural and Biophysical Characterization of the Interactions between Calmodulin and the Pleckstrin Homology Domain of Akt.

27 March 2020

cites work

1 reference

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Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production

22 May 2018

1 reference

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PARP-1 regulates resistance of pancreatic cancer to TRAIL therapy

22 May 2018

1 reference

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Structural and biophysical characterization of the interactions between the death domain of Fas receptor and calmodulin.

22 May 2018

1 reference

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Trio engagement via plasma membrane phospholipids and the myristoyl moiety governs HIV-1 matrix binding to bilayers

22 May 2018

1 reference

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Optimized Phospholipid Bilayer Nanodiscs Facilitate High-Resolution Structure Determination of Membrane Proteins

22 May 2018

1 reference

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Inositol tetrakisphosphate limits NK cell effector functions by controlling PI3K signaling

22 May 2018

1 reference

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Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers

22 May 2018

1 reference

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NMR analyses of the interaction between the FYVE domain of early endosome antigen 1 (EEA1) and phosphoinositide embedded in a lipid bilayer

22 May 2018

1 reference

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NMR View: A computer program for the visualization and analysis of NMR data

22 May 2018

1 reference

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Vascular smooth muscle cell Smad4 gene is important for mouse vascular development.

22 May 2018

1 reference

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NMR, biophysical, and biochemical studies reveal the minimal Calmodulin binding domain of the HIV-1 matrix protein

22 May 2018

1 reference

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Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Phosphatidylserine is a critical modulator for Akt activation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Phosphoinositide-incorporated lipid-protein nanodiscs: A tool for studying protein-lipid interactions

22 May 2018

1 reference

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Binding of calmodulin to the HIV-1 matrix protein triggers myristate exposure.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Physiological regulation of Akt activity and stability.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Bacterial Pleckstrin Homology Domains: A Prokaryotic Origin for the PH Domain

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Chapter 11 - Reconstitution of membrane proteins in phospholipid bilayer nanodiscs

22 May 2018

1 reference

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Membrane protein assembly into Nanodiscs

22 May 2018

1 reference

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The nanodisc: a novel tool for membrane protein studies

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Structure of the Myristylated Human Immunodeficiency Virus Type 2 Matrix Protein and the Role of Phosphatidylinositol-(4,5)-Bisphosphate in Membrane Targeting

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Calmodulin modulates Akt activity in human breast cancer cell lines

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Intracellular signaling by Akt: bound to be specific

22 May 2018

1 reference

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A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

22 May 2018

1 reference

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AKT/PKB signaling: navigating downstream

22 May 2018

1 reference

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Ca(2+)/calmodulin directly interacts with the pleckstrin homology domain of AKT1.

22 May 2018

1 reference

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Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo

22 May 2018

1 reference

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The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer

22 May 2018

1 reference

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Pleckstrin homology (PH) domains and phosphoinositides

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.

22 May 2018

1 reference

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Structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly.

22 May 2018

1 reference

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Protein-peptide interaction studies demonstrate the versatility of calmodulin target protein binding

22 May 2018

1 reference

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Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Perturbations of the AKT signaling pathway in human cancer

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

The CCPN data model for NMR spectroscopy: development of a software pipeline

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Calmodulin-mediated activation of Akt regulates survival of c-Myc-overexpressing mouse mammary carcinoma cells

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Calmodulin's flexibility allows for promiscuity in its interactions with target proteins and peptides

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Structure, regulation and function of PKB/AKT--a major therapeutic target

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Solution structure and backbone dynamics of the pleckstrin homology domain of the human protein kinase B (PKB/Akt). Interaction with inositol phosphates

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Self‐assembly of single integral membrane proteins into soluble nanoscale phospholipid bilayers

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Novel aspects of calmodulin target recognition and activation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Initiating oncogenic event determines gene-expression patterns of human breast cancer models

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Calmodulin in action: diversity in target recognition and activation mechanisms.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Calmodulin: a prototypical calcium sensor

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

A novel target recognition revealed by calmodulin in complex with Ca2+-calmodulin-dependent kinase kinase

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

A novel approach for sequential assignment of 1H, 13C, and 15N spectra of proteins: heteronuclear triple-resonance three-dimensional NMR spectroscopy. Application to calmodulin

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Calmodulin levels in oestrogen receptor positive and negative human breast tumours

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

Targeting phospshatidylinositol 3-kinase signaling with novel phosphatidylinositol 3,4,5-triphosphate antagonists.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5217684

A specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transition.

14 August 2018

1 reference

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Self-Assembly of Discoidal Phospholipid Bilayer Nanoparticles with Membrane Scaffold Proteins

14 August 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M116.752816

Mapping the Phosphoinositide-Binding Site on Chick Cofilin Explains How PIP2 Regulates the Cofilin-Actin Interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M116.752816

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M116.752816

The main-chain dynamics of the dynamin pleckstrin homology (PH) domain in solution: analysis of 15N relaxation with monomer/dimer equilibration 1 1 Edited by P.E.Wright

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M116.752816

Differential regulation of Akt/protein kinase B isoforms during cell cycle progression

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27872186

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M116.752816

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27872186%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27872186%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

PubMed publication ID

27872186

1 reference