(Q34724853)

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Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production

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scholarly article

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Europe PubMed Central

PubMed publication ID

4 August 2017

Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production (English)

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Europe PubMed Central

PubMed publication ID

4 August 2017

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25097034%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

6

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1 June 2020

9

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1 June 2020

Amy H. Andreotti

8

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Amy H Andreotti

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1 June 2020

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Xinxin Wang

1

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1 June 2020

Scott E Boyken

2

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1 June 2020

Xiaolu Xu

4

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1 June 2020

Ryan P Rimer

5

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1 June 2020

Andrey S Shaw

7

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1 June 2020

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5 August 2014

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4 August 2017

Science Signaling

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1 June 2020

7

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1 June 2020

337

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1 June 2020

ra74

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1 June 2020

Solution Structure of Calmodulin Bound to the Binding Domain of the HIV-1 Matrix Protein

1 reference

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7 July 2018

CD28 and ITK signals regulate autoreactive T cell trafficking.

1 reference

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Allosteric mechanism of water-channel gating by Ca2+–calmodulin

1 reference

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7 July 2018

Ratiometric Ca²⁺ measurements using the FlexStation(®)Scanning Fluorometer

1 reference

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7 July 2018

A voltage-gated sodium channel is essential for the positive selection of CD4(+) T cells

1 reference

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7 July 2018

Rescue of the aggregation prone Itk Pleckstrin Homology domain by two mutations derived from the related kinases, Btk and Tec.

1 reference

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Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies

1 reference

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7 July 2018

Crystallographic basis for calcium regulation of sodium channels

1 reference

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Conditional peripheral membrane proteins: facing up to limited specificity

1 reference

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Reorganizing the protein space at the Universal Protein Resource (UniProt)

1 reference

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7 July 2018

Itk controls the spatiotemporal organization of T cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

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1 reference

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7 July 2018

T-cell signaling regulated by the Tec family kinase, Itk.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

I-TASSER: a unified platform for automated protein structure and function prediction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Modular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible function in short-term synaptic plasticity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Bacterial Pleckstrin Homology Domains: A Prokaryotic Origin for the PH Domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Proline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Protein structure prediction on the Web: a case study using the Phyre server

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Calmodulin modulates Akt activity in human breast cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Calcium signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Calcium signalling in lymphocyte activation and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Ca(2+)/calmodulin directly interacts with the pleckstrin homology domain of AKT1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Pleckstrin homology (PH) domains and phosphoinositides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Myristoyl moiety of HIV Nef is involved in regulation of the interaction with calmodulin in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Mars -- robust automatic backbone assignment of proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Using NMRView to visualize and analyze the NMR spectra of macromolecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Crystal structure of a myristoylated CAP-23/NAP-22 N-terminal domain complexed with Ca2+/calmodulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte development

1 reference

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7 July 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Nef of HIV-1 interacts directly with calcium-bound calmodulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

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Autoinhibition mechanism of proto-Dbl.

1 reference

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1 reference

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7 July 2018

Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Solution structure of calmodulin-W-7 complex: the basis of diversity in molecular recognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Comparative protein modelling by satisfaction of spatial restraints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Molecular and structural basis of target recognition by calmodulin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Calcium-induced conformational transition revealed by the solution structure of apo calmodulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269470

7 July 2018

PI3K signalling: the path to discovery and understanding.

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005147

21 January 2018

Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005147

21 January 2018

Recognition pliability is coupled to structural heterogeneity: a calmodulin intrinsically disordered binding region complex

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005147

21 January 2018

Apo-calmodulin binds with its C-terminal domain to the N-methyl-D-aspartate receptor NR1 C0 region.

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005147

21 January 2018

Interdomain cooperativity of calmodulin bound to melittin preferentially increases calcium affinity of sites I and II.

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005147

21 January 2018

Lobe-dependent regulation of ryanodine receptor type 1 by calmodulin.

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005147

21 January 2018

Direct involvement of protein myristoylation in myristoylated alanine-rich C kinase substrate (MARCKS)-calmodulin interaction.

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005147

21 January 2018

Calmodulin target database

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005147

21 January 2018

An interdomain linker increases the thermostability and decreases the calcium affinity of the calmodulin N-domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/25097034

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25097034

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of Tec family kinases alters T helper cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25097034

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calmodulin signaling: analysis and prediction of a disorder-dependent molecular recognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/25097034

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive regulation of Itk PH domain function by soluble IP4

1 reference

https://pubmed.ncbi.nlm.nih.gov/25097034

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Th17 cells exhibit a distinct calcium profile from Th1 and Th2 cells and have Th1-like motility and NF-AT nuclear localization

1 reference

https://pubmed.ncbi.nlm.nih.gov/25097034

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1126/SCISIGNAL.2005147

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25097034%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25097034%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25097034%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

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