(Q48089225)

English

Pharmacokinetic modeling of the anticonvulsant response of oxazepam in rats using the pentylenetetrazol threshold concentration as pharmacodynamic measure

scientific article published on April 1, 1988

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

8 February 2018

http://europepmc.org/abstract/MED/3418496

Pharmacokinetic modeling of the anticonvulsant response of oxazepam in rats using the pentylenetetrazol threshold concentration as pharmacodynamic measure (English)

1 reference

10.1007/BF01062261

https://api.crossref.org/works/10.1007/BF01062261

9 January 2023

pharmacokinetics

1 reference

based on heuristic

inferred from title

pharmacodynamics

1 reference

based on heuristic

inferred from title

author name string

J. Dingemanse

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A3418496

9 January 2023

F. A. Sollie

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A3418496

9 January 2023

D. D. Breimer

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A3418496

9 January 2023

M. Danhof

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A3418496

9 January 2023

language of work or name

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=3418496

9 January 2023

publication date

1 April 1988

1 reference

Europe PubMed Central

PubMed publication ID

8 February 2018

http://europepmc.org/abstract/MED/3418496

full work available at URL

http://link.springer.com/content/pdf/10.1007/BF01062261.pdf

Portable Document Format

1 reference

10.1007/BF01062261

https://api.crossref.org/works/10.1007/BF01062261

9 January 2023

http://link.springer.com/article/10.1007/BF01062261/fulltext.html

1 reference

10.1007/BF01062261

https://api.crossref.org/works/10.1007/BF01062261

9 January 2023

http://link.springer.com/content/pdf/10.1007/BF01062261

1 reference

10.1007/BF01062261

https://api.crossref.org/works/10.1007/BF01062261

9 January 2023

Journal of Pharmacokinetics and Pharmacodynamics

1 reference

Europe PubMed Central

PubMed publication ID

8 February 2018

http://europepmc.org/abstract/MED/3418496

16

1 reference

Europe PubMed Central

PubMed publication ID

8 February 2018

http://europepmc.org/abstract/MED/3418496

2

1 reference

Europe PubMed Central

PubMed publication ID

8 February 2018

http://europepmc.org/abstract/MED/3418496

203-228

1 reference

Europe PubMed Central

PubMed publication ID

8 February 2018

http://europepmc.org/abstract/MED/3418496

https://scigraph.springernature.com/pub.10.1007/bf01062261

0 references

Benzodiazepines: clinical pharmacology and therapeutic use.

1 reference

https://api.crossref.org/works/10.1007%2FBF01062261

21 January 2018

Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models

1 reference

https://api.crossref.org/works/10.1007%2FBF01062261

21 January 2018

Active drug metabolites. An overview of their relevance in clinical pharmacokinetics

1 reference

https://api.crossref.org/works/10.1007%2FBF01062261

21 January 2018

Profile of acute tolerance to three sedative anxiolytics

1 reference

https://api.crossref.org/works/10.1007%2FBF01062261

21 January 2018

Optimizing the pentetrazol infusion test for seizure threshold measurement.

1 reference

https://api.crossref.org/works/10.1007%2FBF01062261

21 January 2018

Brain levels of metrazol determined with a new gas chromatographic procedure.

1 reference

https://api.crossref.org/works/10.1007%2FBF01062261

21 January 2018

The effect of solvents on the potency of chlordiazepoxide, diazepam, medazepam and nitrazepam.

1 reference

https://api.crossref.org/works/10.1007%2FBF01062261

21 January 2018

Species differences in diazepam metabolism—I. Metabolism of diazepam metabolites

1 reference

https://api.crossref.org/works/10.1007%2FBF01062261

21 January 2018

Seizure control following administration of anticonvulsant drugs in the quaking mouse

1 reference

https://api.crossref.org/works/10.1007%2FBF01062261

21 January 2018

A timed intravenous pentylenetetrazol infusion seizure model for quantitating the anticonvulsant effect of valproic acid in the rat.

1 reference

https://api.crossref.org/works/10.1007%2FBF01062261

21 January 2018

Effects of tetrazole derivatives on [3H]diazepam binding in vitro: Correlation with convulsant potency

1 reference

https://api.crossref.org/works/10.1007%2FBF01062261

21 January 2018

Stereospecific benzodiazepine receptor binding by the enantiomers of oxazepam sodium hemisuccinate

1 reference

https://api.crossref.org/works/10.1007%2FBF01062261

21 January 2018

Mice and rats are sensitized to the proconvulsant action of a benzodiazepine-receptor inverse agonist (FG 7142) following a single dose of lorazepam

1 reference

https://api.crossref.org/works/10.1007%2FBF01062261

21 January 2018

Long-lasting single-dose tolerance to neurologic deficits induced by diazepam

1 reference

https://api.crossref.org/works/10.1007%2FBF01062261

21 January 2018

Acute tolerance to diazepam induced by benzodiazepines

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma concentrations of clobazam and its N-desmethyl metabolite; protection against pentetrazol-induced convulsions in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of drug action in disease states. XIV. Effect of infusion rate on pentylenetetrazol concentrations in serum, brain and cerebrospinal fluid of rats at onset of convulsions

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabolic disposition of oxazepam in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CHRONIC INTRAVENOUS CANNULAS FOR RATS

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Application of radioreceptor assay of benzodiazepines for toxicology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Timed intravenous infusion of metrazol and strychnine for testing anticonvulsant drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical Pharmacokinetics of Oxazepam and Lorazepam

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of heparin or salicylate infusion on serum protein binding and on concentrations of phenytoin in serum, brain and cerebrospinal fluid of rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased brain uptake of lidocaine during bicuculline-induced status epilepticus in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strategy to assess the role of (inter)active metabolites in pharmacodynamic studies in-vivo: a model study with heptabarbital.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional cerebral blood flow during bicuculline-induced seizures in the newborn piglet: effect of phenobarbital.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tolerance to, and dependence on, some non-opiate psychotropic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions of pentamethylenetetrazole and tetrazole analogues with the picrotoxinin site of the benzodiazepine-gaba receptor-ionophore complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and use of a new electroshock seizure apparatus, and analysis of factors altering seizure threshold and pattern

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxicity of three drug solvents

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Motor paralysis increases brain uptake of lidocaine during status epilepticus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of drug action in disease states. XVI. Pharmacodynamics of theophylline-induced seizures in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of the blood-brain pH gradient on brain phenobarbital uptake during status epilepticus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of drug action in disease states. VII. Effect of experimental renal dysfunction on the pharmacodynamics of ethanol in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro correlates of benzodiazepine cerebrospinal fluid uptake, pharmacodynamic action and peripheral distribution.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrous and circadian periodicity and electroshock convulsions in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the toxicology of dimethylformamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein measurement with the Folin phenol reagent

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ELSMOS--an extended least squares modelling system in FORTRAN IV for mini- or micro-computer implementation

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of drug action in disease states. I. Effect of infusion rate on phenobarbital concentrations in serum, brain and cerebrospinal fluid of normal rats at onset of loss of righting reflex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of sodium valproate and GABA metabolism in CNS of the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between pentylenetetrazol-induced seizures and brain pentylenetetrazol levels in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The fate and excretion of C14-labeled pentylenetetrazol in the rat, with comments on analytical methods for pentylenetetrazol

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biotransformation of oxazepam (7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one) in man, miniature swine and rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the measurement in rats of the convulsant effect of drugs and the changes which follow electroconvulsive shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute tolerance to diazepam in mice: pharmacokinetic considerations

1 reference

https://pubmed.ncbi.nlm.nih.gov/3418496

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug Metabolism and Disposition

47

14

41

author name string

S. F. Sisenwine

publication date

1986

1 reference

10.1007/BF01062261

https://api.crossref.org/works/10.1007/BF01062261

9 January 2023

Pharmacological Reviews

56

23

135

author name string

H. Kalant

publication date

1971

1 reference

10.1007/BF01062261

https://api.crossref.org/works/10.1007/BF01062261

9 January 2023

Identifiers

10.1007/BF01062261

1 reference

Europe PubMed Central

PubMed publication ID

8 February 2018

http://europepmc.org/abstract/MED/3418496

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 February 2018

http://europepmc.org/abstract/MED/3418496

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