(Q48127305)

English

Quinolinic acid formation in immune-activated mice: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(-3-nitrophenyl)thiazol-2yl]-benzenesul fonamide (Ro 61-8048), two potent and selective inhibitors of kynurenine hydroxylase.

scientific article published in August 1999

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scholarly article

1 reference

Europe PubMed Central

8 February 2018

http://europepmc.org/abstract/MED/10462134

Quinolinic acid formation in immune-activated mice: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(-3-nitrophenyl)thiazol-2yl]-benzenesul fonamide (Ro 61-8048), two potent and selective inhibitors of kynurenine hydroxylase. (English)

1 reference

Europe PubMed Central

8 February 2018

http://europepmc.org/abstract/MED/10462134

author name string

Chiarugi A

1

1 reference

Europe PubMed Central

8 February 2018

http://europepmc.org/abstract/MED/10462134

Moroni F

2

1 reference

Europe PubMed Central

8 February 2018

http://europepmc.org/abstract/MED/10462134

publication date

1 August 1999

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Europe PubMed Central

8 February 2018

http://europepmc.org/abstract/MED/10462134

number of pages

9

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based on heuristic

inferred from page(s)

Neuropharmacology

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Europe PubMed Central

8 February 2018

http://europepmc.org/abstract/MED/10462134

38

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Europe PubMed Central

8 February 2018

http://europepmc.org/abstract/MED/10462134

1225-1233

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Europe PubMed Central

8 February 2018

http://europepmc.org/abstract/MED/10462134

8

1 reference

Europe PubMed Central

8 February 2018

http://europepmc.org/abstract/MED/10462134

Presence of 3-hydroxyanthranilic acid in rat tissues and evidence for its production from anthranilic acid in the brain.

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Quinolinic acid accumulation in injured spinal cord: time course, distribution, and species differences between rat and guinea pig

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Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities.

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Comparison of the neurochemical and behavioral effects resulting from the inhibition of kynurenine hydroxylase and/or kynureninase

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Nicotinylalanine increases cerebral kynurenic acid content and has anticonvulsant activity

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Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia.

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Cytotoxicity of 3-hydroxykynurenine in a neuronal hybrid cell line

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Neurotoxin quinolinic acid is selectively elevated in spinal cords of rats with experimental allergic encephalomyelitis

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On the excitotoxic properties of quinolinic acid, 2,3-piperidine dicarboxylic acids and structurally related compounds

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Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid

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Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status

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Relationship of neurologic status in macaques infected with the simian immunodeficiency virus to cerebrospinal fluid quinolinic acid and kynurenic acid

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Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid

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Quantification of quinolinic acid in rat brain, whole blood, and plasma by gas chromatography and negative chemical ionization mass spectrometry: effects of systemic L-tryptophan administration on brain and blood quinolinic acid concentrations

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Determination of serum kynurenine and hepatic tryptophan dioxygenase activity by high-performance liquid chromatography.

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Kynurenine pathway inhibition reduces neurotoxicity of HIV-1-infected macrophages.

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Antibodies to quinolinic acid reveal localization in select immune cells rather than neurons or astroglia

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The excitotoxin quinolinic acid is present and unevenly distributed in the rat brain

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Presence of Kynurenic Acid in the Mammalian Brain

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Modulation of Quinolinic and Kynurenic Acid Content in the Rat Brain: Effects of Endotoxins and Nicotinylalanine

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Hydrogen peroxide-mediated neuronal cell death induced by an endogenous neurotoxin, 3-hydroxykynurenine

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Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase.

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Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse

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Mechanism of delayed increases in kynurenine pathway metabolism in damaged brain regions following transient cerebral ischemia.

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Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain

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Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS

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Cerebral synthesis and release of kynurenic acid: an endogenous antagonist of excitatory amino acid receptors.

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The metabolism of [carboxyl-14C]anthranilic acid. I. The incorporation of radioactivity into NAD+ and NADP+.

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Identification of quinolinic acid in rat and human brain tissue

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Indoleamine 2,3-dioxygenase

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Quinolinic acid in neurological disease: opportunities for novel drug discovery.

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7 January 2021

based on heuristic

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Identifiers

10.1016/S0028-3908(99)00048-9

1 reference

Europe PubMed Central

8 February 2018

http://europepmc.org/abstract/MED/10462134

1 reference

Europe PubMed Central

8 February 2018

http://europepmc.org/abstract/MED/10462134

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