(Q48207625)

English

Glucocorticoids exacerbate cognitive deficits in TDP-25 transgenic mice via a glutathione-mediated mechanism: implications for aging, stress and TDP-43 proteinopathies.

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scholarly article

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/23325230

Glucocorticoids exacerbate cognitive deficits in TDP-25 transgenic mice via a glutathione-mediated mechanism: implications for aging, stress and TDP-43 proteinopathies (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6704880&resulttype=core&format=json

11 May 2020

author name string

Antonella Caccamo

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6704880&resulttype=core&format=json

11 May 2020

David X Medina

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6704880&resulttype=core&format=json

11 May 2020

Salvatore Oddo

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6704880&resulttype=core&format=json

11 May 2020

language of work or name

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publication date

1 January 2013

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/23325230

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6704880&resulttype=core&format=json

11 May 2020

33

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6704880&resulttype=core&format=json

11 May 2020

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6704880&resulttype=core&format=json

11 May 2020

906-913

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6704880&resulttype=core&format=json

11 May 2020

Glucocorticoids, stress, and their adverse neurological effects: relevance to aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular dissection of autophagy: two ubiquitin-like systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruptive effects of glucocorticoids on glutathione peroxidase biochemistry in hippocampal cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of aging: an appraisal of the oxidative stress hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Higher order arrangement of the eukaryotic nuclear bodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of age and dexamethasone treatment on glucocorticoid response element and activating protein-1 binding activity in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural diversity and functional implications of the eukaryotic TDP gene family

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of protein function by glutathionylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent advances in the genetics of amyotrophic lateral sclerosis and frontotemporal dementia: common pathways in neurodegenerative disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genome-wide atlas of gene expression in the adult mouse brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress-induced changes in hippocampal function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pro-oxidant shift in glutathione redox state during aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrogen peroxide release by mitochondria increases during aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione dysregulation and the etiology and progression of human diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent advances in the genetics of amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neural regulation of endocrine and autonomic stress responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial glutathione, a key survival antioxidant

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic effect between proteasome and autophagosome in the clearance of polyubiquitinated TDP-43.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: a spectrum of TDP-43 proteinopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylene blue reduces aβ levels and rescues early cognitive deficit by increasing proteasome activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent changes in TDP-43 levels in a mouse model of Alzheimer disease are linked to Aβ oligomers accumulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of 5-lipoxygenase in the corticosteroid-dependent amyloid beta formation: in vitro and in vivo evidence

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dexamethasone potentiated Aβ-induced learning and memory impairment in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress acts cumulatively to precipitate Alzheimer's disease-like tau pathology and cognitive deficits.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular dissection of TDP-43 proteinopathies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucocorticoid pulsatility and rapid corticosteroid actions in the central stress response

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of autophagy by neuropathological protein TDP-43.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cognitive decline typical of frontotemporal lobar degeneration in transgenic mice expressing the 25-kDa C-terminal fragment of TDP-43.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging and stress: past hypotheses, present approaches and perspectives

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Controversies surrounding glucocorticoid-mediated cell death in the hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucocorticoids may alter antioxidant enzyme capacity in the brain: baseline studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A protein conjugation system essential for autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress, Glucocorticoids, and Damage to the Nervous System: The Current State of Confusion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23325230

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3314-12.2013

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6704880&resulttype=core&format=json

11 May 2020

release_xyknxo4kbbh3jmpkrexpzlfxi4

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6704880&resulttype=core&format=json

11 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6704880&resulttype=core&format=json

11 May 2020

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