(Q48273890)

English

Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-beta in cultured cortical neurons: evidence that tau phosphorylation is the limiting factor in amyloid-beta-induced cell death.

scientific article published on 7 February 2007

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scholarly article

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/17298384

Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-beta in cultured cortical neurons: evidence that tau phosphorylation is the limiting factor in amyloid-beta-induced cell death. (English)

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/17298384

phosphorylation

1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

4

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/17298384

author name string

Julia Leschik

1

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Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/17298384

Alfred Welzel

2

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Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/17298384

Carina Weissmann

3

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/17298384

Roland Brandt

5

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Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/17298384

language of work or name

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publication date

7 February 2007

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Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/17298384

Journal of Neurochemistry

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Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/17298384

101

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10 February 2018

http://europepmc.org/abstract/MED/17298384

5

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Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/17298384

1303-1315

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Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/17298384

Pro-apoptotic effect of presenilin 2 (PS2) overexpression is associated with down-regulation of Bcl-2 in cultured neurons

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Functional interactions of tau and their relevance for Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Proteolytical processing of mutated human amyloid precursor protein in transgenic mice.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Characterization of human presenilin 1 transgenic rats: increased sensitivity to apoptosis in primary neuronal cultures.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Ballooned neurons in select neurodegenerative diseases contain phosphorylated neurofilament epitopes.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Structural and functional implications of tau hyperphosphorylation: information from phosphorylation-mimicking mutated tau proteins.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Phosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau protein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Ballooned neurones in the limbic lobe are associated with Alzheimer type pathology and lack diagnostic specificity.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Neuronal and glial DNA fragmentation in Pick's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Phosphoprotein phosphatase activities in Alzheimer disease brain

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

The extent of phosphorylation of fetal tau is comparable to that of PHF-tau from Alzheimer paired helical filaments

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Pathways towards and away from Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Neurotrophins differentially regulate the survival and morphological complexity of human CNS model neurons.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Direct interaction of soluble human recombinant tau protein with Abeta 1-42 results in tau aggregation and hyperphosphorylation by tau protein kinase II.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Tau is essential to beta -amyloid-induced neurotoxicity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Evidence for apoptotic cell death in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Abeta amyloidosis induces the initial stage of tau accumulation in APP(Sw) mice.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Amyloid beta peptide induces tau phosphorylation and loss of cholinergic neurons in rat primary septal cultures

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Neuron loss in APP transgenic mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04435.X

21 January 2018

Identifiers

10.1111/J.1471-4159.2006.04435.X

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/17298384

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/17298384

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