(Q48280428)

10 February 2018

title

A bioinorganic view of Alzheimer's disease: when misplaced metal ions (re)direct the electrons to the wrong target. (English)

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10 February 2018

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Peter Faller

1

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10 February 2018

Christelle Hureau

series ordinal

2

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10 February 2018

language of work or name

English

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publication date

23 November 2012

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10 February 2018

Chemistry—A European Journal

published in

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10 February 2018

volume

18

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10 February 2018

issue

50

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10 February 2018

page(s)

15910-15920

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10 February 2018

Iron-chelating backbone coupled with monoamine oxidase inhibitory moiety as novel pluripotential therapeutic agents for Alzheimer's disease: a tribute to Moussa Youdim

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21 January 2018

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Quantitative imaging of zinc, copper and lead in three distinct regions of the human brain by laser ablation inductively coupled plasma mass spectrometry

21 January 2018

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Imaging of copper, zinc, and other elements in thin section of human brain samples (hippocampus) by laser ablation inductively coupled plasma mass spectrometry

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NMDA receptor activation mediates copper homeostasis in hippocampal neurons

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Disruption of hippocampal CA3 network: effects on episodic-like memory processing in C57BL/6J mice.

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Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors

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Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis

21 January 2018

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Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease

21 January 2018

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The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

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Oxidative stress in neurodegeneration: cause or consequence?

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Neurodegenerative diseases and oxidative stress

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Mitochondrial dysfunction: common final pathway in brain aging and Alzheimer's disease--therapeutic aspects

21 January 2018

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Amyloid oligomers: formation and toxicity of Abeta oligomers

21 January 2018

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Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

21 January 2018

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Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion.

21 January 2018

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In vivo reduction of amyloid-beta by a mutant copper transporter

21 January 2018

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Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

21 January 2018

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Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

21 January 2018

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Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease

21 January 2018

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 January 2018

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Copper chelator induced efficient episodic memory recovery in a non-transgenic Alzheimer's mouse model

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Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

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Substoichiometric levels of Cu2+ ions accelerate the kinetics of fiber formation and promote cell toxicity of amyloid-{beta} from Alzheimer disease

21 January 2018

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Copper in Alzheimer disease: too much, too little, or misplaced?

21 January 2018

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Elevated labile Cu is associated with oxidative pathology in Alzheimer disease.

21 January 2018

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Copper(II) binding to amyloid-beta fibrils of Alzheimer's disease reveals a picomolar affinity: stoichiometry and coordination geometry are independent of Abeta oligomeric form

21 January 2018

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Reevaluation of copper(I) affinity for amyloid-β peptides by competition with ferrozine--an unusual copper(I) indicator

21 January 2018

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Zinc binding to amyloid-beta: isothermal titration calorimetry and Zn competition experiments with Zn sensors.

21 January 2018

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Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase

21 January 2018

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Affinity gradients drive copper to cellular destinations

21 January 2018

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

21 January 2018

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Amyloid beta-protein assembly and Alzheimer disease

21 January 2018

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Rapid induction of Alzheimer A beta amyloid formation by zinc.

21 January 2018

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Abeta-mediated ROS production by Cu ions: structural insights, mechanisms and relevance to Alzheimer's disease.

21 January 2018

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Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

21 January 2018

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Electrochemical and homogeneous electron transfers to the Alzheimer amyloid-beta copper complex follow a preorganization mechanism

21 January 2018

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Vitamin E forms in Alzheimer's disease: a review of controversial and clinical experiences

21 January 2018

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Preparation and study of new poly-8-hydroxyquinoline chelators for an anti-Alzheimer strategy.

21 January 2018

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Metal swap between Zn7-metallothionein-3 and amyloid-beta-Cu protects against amyloid-beta toxicity.

21 January 2018

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Two functions, one molecule: a metal-binding and a targeting moiety to combat Alzheimer's disease.

21 January 2018

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

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Therapeutic redistribution of metal ions to treat Alzheimer's disease.

21 January 2018

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Synthesis, characterization, and metal coordinating ability of multifunctional carbohydrate-containing compounds for Alzheimer's therapy.

21 January 2018

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Combating Alzheimer's disease with multifunctional molecules designed for metal passivation.

21 January 2018

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Bifunctional compounds for controlling metal-mediated aggregation of the aβ42 peptide

21 January 2018

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Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols

21 January 2018

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The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/CHEM.201202697

1 reference

10 February 2018

release_d5nqjyp4qzemzc5bxy25rgg254

Fatcat ID

0 references

PubMed ID

23180511

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10 February 2018