(Q48350855)

English

The free radical antioxidant vitamin E protects cortical synaptosomal membranes from amyloid beta-peptide(25-35) toxicity but not from hydroxynonenal toxicity: relevance to the free radical hypothesis of Alzheimer's disease.

scientific article published in November 1998

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scholarly article

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/9814551

The free radical antioxidant vitamin E protects cortical synaptosomal membranes from amyloid beta-peptide(25-35) toxicity but not from hydroxynonenal toxicity: relevance to the free radical hypothesis of Alzheimer's disease. (English)

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/9814551

Alzheimer's disease

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D Allan Butterfield

7

object named as

D A Butterfield

1 reference

Europe PubMed Central

10 February 2018

author name string

R Subramaniam

1

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Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/9814551

T Koppal

2

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/9814551

M Green

3

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/9814551

S Yatin

4

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/9814551

B Jordan

5

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/9814551

J Drake

6

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/9814551

publication date

1 November 1998

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/9814551

Neurochemical Research

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Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/9814551

23

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Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/9814551

1403-1410

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Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/9814551

11

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Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/9814551

https://scigraph.springernature.com/pub.10.1023/a:1020754807671

0 references

The intracellular component of cellular 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) reduction is specifically inhibited by beta-amyloid peptides.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of hyperoxia-induced alterations in synaptosomal membrane-associated proteins by N-tert-butyl-alpha-phenylnitrone and 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (Tempol).

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased antioxidant enzyme activity in amyloid beta protein-resistant cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The lipid peroxidation product, 4-hydroxy-2-trans-nonenal, alters the conformation of cortical synaptosomal membrane proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta peptide (25-35) inhibits Na+-dependent glutamate uptake in rat hippocampal astrocyte cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The acute neurotoxic effect of beta-amyloid on mature cultures of rat hippocampal neurons is attenuated by the anti-oxidant U-78517F.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta-peptide toxicity in hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamine synthetase-induced enhancement of beta-amyloid peptide A beta (1-40) neurotoxicity accompanied by abrogation of fibril formation and A beta fragmentation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenal.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications to Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative modification of glutamine synthetase by amyloid beta peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrogen peroxide mediates amyloid beta protein toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid peptide-derived, oxygen-dependent free radicals inhibit glutamate uptake in cultured astrocytes: implications for Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of ischemia/reperfusion-induced alterations in synaptosomal membrane-associated proteins and lipids by N-tert-butyl-alpha-phenylnitrone and difluoromethylornithine

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of age-induced beta-amyloid neurotoxicity in rat hippocampal cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

4-Hydroxynonenal, an aldehydic product of lipid peroxidation, impairs signal transduction associated with muscarinic acetylcholine and metabotropic glutamate receptors: possible action on G alpha(q/11).

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-protein and the genetics of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vitamin E protects against Alzheimer's amyloid peptide (25-35)-induced changes in neocortical synaptosomal membrane lipid structure and composition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electron paramagnetic resonance investigations of free radical-induced alterations in neocortical synaptosomal membrane protein infrastructure

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free radical oxidation of brain proteins in accelerated senescence and its modulation by N-tert-butyl-alpha-phenylnitrone

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidatively induced structural alteration of glutamine synthetase assessed by analysis of spin label incorporation kinetics: relevance to Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress hypothesis in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-peptide spin trapping. I: Peptide enzyme toxicity is related to free radical spin trap reactivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid-associated free radical oxidative stress and neurotoxicity: implications for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of 2-cyclohexene-1-one-induced glutathione diminution on ischemia/reperfusion-induced alterations in the physical state of brain synaptosomal membrane proteins and lipids.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid-induced toxicity in rat hippocampal cells: in vitro evidence for the involvement of free radicals

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advances in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive oxygen species as causal agents in the neurotoxicity of the Alzheimer's disease-associated amyloid beta peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid beta-peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nordihydroguaiaretic acid protects hippocampal neurons against amyloid beta-peptide toxicity, and attenuates free radical and calcium accumulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress and the pathogenesis of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ischemia/reperfusion-induced changes in membrane proteins and lipids of gerbil cortical synaptosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of amyloid beta protein aggregation and neurotoxicity by rifampicin. Its possible function as a hydroxyl radical scavenger.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9814551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/A:1020754807671

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/9814551

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1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/9814551

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