(Q48407971)

English

Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease.

scientific article published in December 2002

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/12531514

Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease. (English)

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/12531514

Alzheimer's disease

0 references

4

object named as

Bengt Winblad

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

Inge Grundke-Iqbal

7

object named as

Inge Grundke-Iqbal

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

1

object named as

Jin-Jing Pei

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/12531514

Richard F. Cowburn

5

object named as

Richard F Cowburn

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/12531514

6

object named as

Khalid Iqbal

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/12531514

author name string

Heiko Braak

2

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/12531514

Wen-Lin An

3

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/12531514

publication date

1 December 2002

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/12531514

Molecular Brain Research

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/12531514

109

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/12531514

1-2

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/12531514

45-55

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/12531514

Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysis

1 reference

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Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease.

1 reference

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7 January 2021

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Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1 reference

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Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis.

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Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356.

1 reference

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ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1 reference

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A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

1 reference

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7 January 2021

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Silver impregnation of Alzheimer's neurofibrillary changes counterstained for basophilic material and lipofuscin pigment.

1 reference

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Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques.

1 reference

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7 January 2021

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Neuropathological stageing of Alzheimer-related changes

1 reference

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7 January 2021

based on heuristic

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Parvalbumin-immunoreactive structures in the hippocampus of the human adult

1 reference

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7 January 2021

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Identification of normal and pathological aging in prospectively studied nondemented elderly humans

1 reference

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7 January 2021

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Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

p42 mitogen-activated protein kinase in brain: prominent localization in neuronal cell bodies and dendrites.

1 reference

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Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration

1 reference

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7 January 2021

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p42 map kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1Implications for Alzheimer's disease

1 reference

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7 January 2021

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Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphoprotein phosphatase activities in Alzheimer disease brain

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

1 reference

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7 January 2021

based on heuristic

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Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase.

1 reference

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based on heuristic

inferred from DOI database lookup

New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry

1 reference

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based on heuristic

inferred from DOI database lookup

The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Defective brain microtubule assembly in Alzheimer's disease

1 reference

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based on heuristic

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A serine/threonine proline kinase activity is included in the tau protein kinase fraction forming a paired helical filament epitope

1 reference

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Demonstration by fluorescence resonance energy transfer of a close association between activated MAP kinase and neurofibrillary tangles: implications for MAP kinase activation in Alzheimer disease

1 reference

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based on heuristic

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Stimulation of MAP kinase by v-raf transformation of fibroblasts fails to induce hyperphosphorylation of transfected tau.

1 reference

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based on heuristic

inferred from DOI database lookup

Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease.

1 reference

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based on heuristic

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Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

1 reference

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based on heuristic

inferred from DOI database lookup

p44mpk MAP kinase induces Alzheimer type alterations in tau function and in primary hippocampal neurons.

1 reference

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based on heuristic

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Hyperphosphorylation of tau in PHF

1 reference

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based on heuristic

inferred from DOI database lookup

Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes

1 reference

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based on heuristic

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Expression of protein phosphatases (PP-1, PP-2A, PP-2B and PTP-1B) and protein kinases (MAP kinase and P34cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals.

1 reference

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Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain.

1 reference

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based on heuristic

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Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration.

1 reference

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based on heuristic

inferred from DOI database lookup

Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Association of mitogen-activated protein kinase with the microtubule cytoskeleton

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Brain protein kinase PK40erk converts TAU into a PHF-like form as found in Alzheimer's disease.

1 reference

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based on heuristic

inferred from DOI database lookup

The topography and subcellular distribution of mitogen-activated protein kinase kinase1 (MEK1) in adult rat brain and differentiating PC12 cells

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules

1 reference

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based on heuristic

inferred from DOI database lookup

Polyethylene glycol embedding: a technique compatible with immunocytochemistry, enzyme histochemistry, histofluorescence and intracellular staining.

1 reference

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based on heuristic

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The regulation of phosphorylation of tau in SY5Y neuroblastoma cells: the role of protein phosphatases.

1 reference

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based on heuristic

inferred from DOI database lookup

Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The phosphatase inhibitor okadaic acid induces a phosphorylated paired helical filament tau epitope in human LA-N-5 neuroblastoma cells.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0169-328X(02)00488-6

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/12531514

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/12531514

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