(Q48409115)

11 February 2018

title

PARP expression is increased in astrocytes but decreased in motor neurons in the spinal cord of sporadic ALS patients. (English)

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11 February 2018

amyotrophic lateral sclerosis

main subject

astrocyte

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9

Stanley H Appel

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11 February 2018

author name string

Seung H Kim

1

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11 February 2018

Jenny S Henkel

2

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11 February 2018

David R Beers

3

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11 February 2018

Ihsan S Sengun

4

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11 February 2018

Ericka P Simpson

5

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11 February 2018

J Clay Goodman

6

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11 February 2018

Jozsef I Engelhardt

7

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11 February 2018

László Siklós

8

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11 February 2018

publication date

1 January 2003

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11 February 2018

Journal of Neuropathology & Experimental Neurology

published in

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11 February 2018

volume

62

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11 February 2018

issue

1

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11 February 2018

page(s)

88-103

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11 February 2018

Remarkable increase in cerebrospinal fluid 3-nitrotyrosine in patients with sporadic amyotrophic lateral sclerosis

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1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Presence of 4-hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis

21 January 2018

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Colocalization of NOS and SOD1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: an immunohistochemical study

21 January 2018

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A receptor for advanced glycosylation endproducts (AGEs) is colocalized with neurofilament-bound AGEs and SOD1 in motoneurons of ALS: immunohistochemical study

21 January 2018

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Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Inducible nitric oxide synthase (iNOS) and nitrotyrosine immunoreactivity in the spinal cords of transgenic mice with a G93A mutant SOD1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Reduction of acute photodamage in skin by topical application of a novel PARP inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Prevention of oxidant-induced cell death in Caco-2 colon carcinoma cells after inhibition of poly(ADP-ribose) polymerase and Ca2+ chelation: involvement of a common mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

A fast signal-induced activation of Poly(ADP-ribose) polymerase: a novel downstream target of phospholipase c.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Nitric oxide toxicity in CNS white matter: an in vitro study using rat optic nerve

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Role of poly(ADP-ribose) formation in DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Decreases in mouse brain NAD+ and ATP induced by 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP): prevention by the poly(ADP-ribose) polymerase inhibitor, benzamide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Role of peroxynitrite and neuronal nitric oxide synthase in the activation of poly(ADP-ribose) synthetase in a murine model of cerebral ischemia-reperfusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Neuronal accumulation of poly(ADP-ribose) after brain ischaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Apoptosis and expression of DNA repair proteins in ischaemic brain injury in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

DNA damage and activated caspase-3 expression in neurons and astrocytes: evidence for apoptosis in frontotemporal dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Poly(ADP-ribose) polymerase localizes to the centrosomes and chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

PARP co-activates B-MYB through enhanced phosphorylation at cyclin/cdk2 sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Overexpression of poly(ADP-ribose) polymerase disrupts organization of cytoskeletal F-actin and tissue polarity in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Role of SOD-1 and nitric oxide/cyclic GMP cascade on neurofilament aggregation in ALS/MND.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Amyotrophic lateral sclerosis associated with genetic abnormalities in the gene encoding Cu/Zn superoxide dismutase: molecular pathology of five new cases, and comparison with previous reports and 73 sporadic cases of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

High molecular weight complexes of mutant superoxide dismutase 1: age-dependent and tissue-specific accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors: a molecular determinant of selective vulnerability in amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, trientine, and lipoic acid in transgenic ALS mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Poly(ADP-ribose) polymerase: a molecular nick-sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Peroxynitrite inhibits glutamate transporter subtypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Na+ dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) in primary astrocyte cultures: effect of oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

The poly(ADP-ribose) glycohydrolase inhibitor gallotannin blocks oxidative astrocyte death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Trophic support of motoneurons: physiological, pathophysiological, and therapeutic implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Intense superoxide dismutase-1 immunoreactivity in intracytoplasmic hyaline inclusions of familial amyotrophic lateral sclerosis with posterior column involvement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Neuroprotection by metabotropic glutamate receptor agonists on kainate-induced degeneration of motor neurons in spinal cord slices from adult rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

Adult rat brain astrocytes support survival of both NGF-dependent and NGF-insensitive neurones

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F62.1.88

21 January 2018

Identifiers

DOI

10.1093/JNEN/62.1.88

1 reference

11 February 2018

PubMed ID

12528821

1 reference

11 February 2018