(Q48411170)

English

Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia.

scientific article published on 28 September 2006

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scholarly article

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/17006672

Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia. (English)

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/17006672

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Daniel R. Weinberger

8

object named as

Daniel R Weinberger

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Europe PubMed Central

11 February 2018

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Ina Giegling

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Europe PubMed Central

11 February 2018

7

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Dan Rujescu

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/17006672

Kristin K Nicodemus

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Kristin K Nicodemus

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/17006672

Richard E Straub

4

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Richard E Straub

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/17006672

Radhakrishna Vakkalanka

3

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Radhakrishna Vakkalanka

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/17006672

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Bhaskar S Kolachana

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/17006672

Michael F Egan

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/17006672

publication date

28 September 2006

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/17006672

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/17006672

120

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Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/17006672

889-906

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http://europepmc.org/abstract/MED/17006672

6

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/17006672

https://scigraph.springernature.com/pub.10.1007/s00439-006-0257-3

0 references

Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

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Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A highly significant association between a COMT haplotype and schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

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Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

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COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

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Prefrontal neurons and the genetics of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

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The family based association test method: strategies for studying general genotype--phenotype associations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

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Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catechol O -methyltransferase val 158 -met genotype and individual variation in the brain response to amphetamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

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A case-control study of the relationship between the metabotropic glutamate receptor 3 gene and schizophrenia in the Chinese population

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

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Case/pseudocontrol analysis in genetic association studies: A unified framework for detection of genotype and haplotype associations, gene-gene and gene-environment interactions, and parent-of-origin effects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

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Segregation analysis of schizophrenia and related disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate receptor 3 (GRM3) gene variation is not associated with schizophrenia or bipolar affective disorder in the German population

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of memory fields by dopamine D1 receptors in prefrontal cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparison of bayesian methods for haplotype reconstruction from population genotype data

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A family-based study of the association between the G72/G30 genes and schizophrenia in the Chinese population

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association and linkage analyses of RGS4 polymorphisms in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Support for RGS4 as a susceptibility gene for schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulator of G-protein signaling 4 (RGS4) gene is associated with schizophrenia in Irish high density families

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Population variation in linkage disequilibrium across the COMT gene considering promoter region and coding region variation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction between the tryptophan hydroxylase gene and the serotonin transporter gene in schizophrenia but not in bipolar or unipolar affective disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The G72/G30 gene complex and cognitive abnormalities in schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Failure to confirm association between RGS4 haplotypes and schizophrenia in Caucasians

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association study of the DISC1/TRAX locus with schizophrenia in a Japanese population.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Confirming RGS4 as a susceptibility gene for schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catechol-O-methyltransferase (COMT) genotypes and working memory: associations with differing cognitive operations

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catechol-O-methyltransferase polymorphisms and schizophrenia: a transmission disequilibrium study in multiply affected families

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complexity and power in case-control association studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association analysis of the RGS4 gene in Han Chinese and Scottish populations with schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimating haplotype frequencies and standard errors for multiple single nucleotide polymorphisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

No evidence for association between polymorphisms in GRM3 and schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of G72/G30 with schizophrenia in the Chinese population

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of epistasis in linked regions in the Irish study of high-density schizophrenia families

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic linkage and complex diseases, with special reference to psychiatric disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is the G72/G30 locus associated with schizophrenia? single nucleotide polymorphisms, haplotypes, and gene expression analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allelic variation in RGS4 impacts functional and structural connectivity in the human brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic polymorphisms of the RGS4 and dorsolateral prefrontal cortex morphometry among first episode schizophrenia patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic heterogeneity in schizophrenia II: conditional analyses of affected schizophrenia sibling pairs provide evidence for an interaction between markers on chromosome 8p and 14q

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genes, dopamine and cortical signal-to-noise ratio in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association and linkage analysis of RGS4 polymorphisms with schizophrenia and bipolar disorder in Brazil.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A method for the assessment of disease associations with single-nucleotide polymorphism haplotypes and environmental variables in case-control studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The velo-cardio-facial syndrome: a clinical and genetic analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuregulin 1 and susceptibility to schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

No evidence for association to the G72/G30 locus in an independent sample of schizophrenia families

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A New Statistical Method for Haplotype Reconstruction from Population Data

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single nucleotide polymorphism detection: allelic discrimination using TaqMan

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic interaction between alpha4 and beta2 subunits of high affinity nicotinic receptor: analysis in schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

COMT: a common susceptibility gene in bipolar disorder and schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RGS4 mRNA expression in postmortem human cortex is associated with COMT Val158Met genotype and COMT enzyme activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Family-based linkage disequilibrium mapping using SNP marker haplotypes: application to a potential locus for schizophrenia at chromosome 22q11

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relative risk of attention deficits in siblings of patients with schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asymptotic power calculations: description, examples, computer code

1 reference

https://pubmed.ncbi.nlm.nih.gov/17006672

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00439-006-0257-3

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/17006672

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/17006672

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