(Q48413563)

English

Why Have Clinical Trials of Antioxidants to Prevent Neurodegeneration Failed? - A Cellular Investigation of Novel Phenothiazine-Type Antioxidants Reveals Competing Objectives for Pharmaceutical Neuroprotection

scientific article published on 28 November 2016

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27896592

Why Have Clinical Trials of Antioxidants to Prevent Neurodegeneration Failed? - A Cellular Investigation of Novel Phenothiazine-Type Antioxidants Reveals Competing Objectives for Pharmaceutical Neuroprotection (English)

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27896592

neurodegeneration

1 reference

based on heuristic

inferred from title

author name string

Maike J Ohlow

1

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27896592

Selina Sohre

2

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27896592

Matthias Granold

3

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27896592

Mathias Schreckenberger

4

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27896592

Bernd Moosmann

5

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27896592

publication date

28 November 2016

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27896592

Pharmaceutical Research

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27896592

34

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27896592

2

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27896592

378-393

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27896592

Oxidative stress and neurodegeneration: where are we now?

1 reference

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Antioxidants as treatment for neurodegenerative disorders

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1,026 experimental treatments in acute stroke

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Free radical trapping as a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with NXY-059 and free radical scavengers

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Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group

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Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion

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Measurement of striatal H2O2 by microdialysis following global forebrain ischemia and reperfusion in the rat: correlation with the cytotoxic potential of H2O2 in vitro

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Oxidative damage in ischemic stroke revealed using multiple biomarkers.

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21 January 2018

High membrane protein oxidation in the human cerebral cortex

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Nrf2 target genes are induced under marginal selenium-deficiency

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Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality

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21 January 2018

Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat.

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21 January 2018

Nitrones as therapeutics

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21 January 2018

Oxidative nerve cell death in Alzheimer's disease and stroke: antioxidants as neuroprotective compounds

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Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease

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21 January 2018

Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

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Vitamin E and donepezil for the treatment of mild cognitive impairment

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21 January 2018

Idebenone treatment fails to slow cognitive decline in Alzheimer's disease

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21 January 2018

Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects

1 reference

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21 January 2018

Alpha tocopherol in CSF of subjects taking high-dose vitamin E in the DATATOP study. Parkinson Study Group

1 reference

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Mice lacking alpha-tocopherol transfer protein gene have severe alpha-tocopherol deficiency in multiple regions of the central nervous system

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Regulation of ubiquinone metabolism

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Novel imine antioxidants at low nanomolar concentrations protect dopaminergic cells from oxidative neurotoxicity

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21 January 2018

Protective activity of aromatic amines and imines against oxidative nerve cell death

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Antioxidant activity applying an improved ABTS radical cation decolorization assay

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21 January 2018

Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins

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A method to determine the ability of drugs to diffuse through the blood-brain barrier

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Quantitative structure-activity relationship analysis of phenolic antioxidants

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The regulation of reactive oxygen species production during programmed cell death

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Phenothiazine: the seven lives of pharmacology's first lead structure

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Recent advances in the biochemistry and clinical relevance of the isoprostane pathway

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Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial reactive oxygen species and the ubiquitin-conjugating system.

1 reference

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Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke

1 reference

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Phenothiazines interfere with dopaminergic neurodegeneration in Caenorhabditis elegans models of Parkinson's disease

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On the anti-atherogenic effect of the antioxidant BHT in cholesterol-fed rabbits: inverse relation between serum triglycerides and atheromatous lesions

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Can molecular and cellular neuroprotection be translated into therapies for patients?: yes, but not the way we tried it before

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Instability of, and generation of hydrogen peroxide by, phenolic compounds in cell culture media

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A phenothiazine derivative reduces rat brain damage after global or focal ischemia

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The antioxidative, non-psychoactive tricyclic phenothiazine reduces brain damage after experimental traumatic brain injury in mice

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The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties

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1 reference

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Final report on the safety assessment of BHT(1).

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

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https://pubmed.ncbi.nlm.nih.gov/27896592

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1 reference

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1 reference

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inferred from PubMed ID database lookup

Human studies related to protein oxidation: protein carbonyl content as a marker of damage

1 reference

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1 reference

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1 reference

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inferred from PubMed ID database lookup

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1 reference

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Identifiers

10.1007/S11095-016-2068-0

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27896592

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27896592

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