(Q48436702)

English

Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death.

scientific article published in July 1998

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9651198%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9651198%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Andrew P Halestrap

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9651198%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

author name string

H Friberg

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9651198%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

M Ferrand-Drake

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9651198%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

F Bengtsson

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9651198%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

T Wieloch

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9651198%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

language of work or name

0 references

publication date

1 July 1998

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9651198%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9651198%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

18

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9651198%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

14

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9651198%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

5151-5159

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9651198%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptidylproline cis/trans isomerases

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyrophosphate metabolism in the perfused heart and isolated heart mitochondria and its role in regulation of mitochondrial function by calcium

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiologic modeling of cyclosporin kinetics in rat and man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporin A protects against ischemia-reperfusion injury in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspases: killer proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of severe hypoglycemia on brain extracellular calcium and potassium activities, energy, and phospholipid metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Permeability of the blood-brain barrier to the immunosuppressive cyclic peptide cyclosporin A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial dysfunction is a primary event in glutamate neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adeni

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The dentate gyrus in hypoglycemia: pathology implicating excitotoxin-mediated neuronal necrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial permeability transition in the central nervous system: induction by calcium cycling-dependent and -independent pathways.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporin A dramatically ameliorates CA1 hippocampal damage following transient forebrain ischaemia in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for the presence of a reversible Ca2+-dependent pore activated by oxidative stress in heart mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An immunosuppressant, FK506, protects hippocampal neurons from forebrain ischemia in the mongolian gerbil.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cDNA cloning of rat mitochondrial cyclophilin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection by Cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Ca2+-induced membrane transition in mitochondria. II. Nature of the Ca2+ trigger site

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms by which mitochondria transport calcium

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium-dependent opening of a non-specific pore in the mitochondrial inner membrane is inhibited at pH values below 7. Implications for the protective effect of low pH against chemical and hypoxic cell damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

H+-dependent efflux of Ca2+ from heart mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid isolation of metabolically active mitochondria from rat brain and subregions using Percoll density gradient centrifugation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mitochondrial permeability transition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The immunosuppressant FK506 ameliorates ischaemic damage in the rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: a unifying hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of hypothermia on hypoglycemia-induced brain damage in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoglycaemia: brain neurochemistry and neuropathology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of the mitochondrial permeability transition by protease activity in rats: a mechanism of hepatocyte necrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective actions of FK506 in experimental stroke: in vivo evidence against an antiexcitotoxic mechanism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular overflow of neuroactive amino acids during severe insulin-induced hypoglycemia: in vivo dialysis of the rat hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial permeability transition triggers lymphocyte apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and N-terminal sequencing of peptidyl-prolyl cis-trans-isomerase from rat liver mitochondrial matrix reveals the existence of a distinct mitochondrial cyclophilin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral extracellular calcium activity in severe hypoglycemia: relation to extracellular potassium and energy state.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial permeability transition is a central coordinating event of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporin A delays mitochondrial depolarization induced by N-methyl-D-aspartate in cortical neurons: evidence of the mitochondrial permeability transition

1 reference

https://pubmed.ncbi.nlm.nih.gov/9651198

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.18-14-05151.1998

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9651198%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9651198%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9651198%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q48436702&oldid=1719462318"