(Q48528499)

12 February 2018

title

Insights into lasalocid A ring formation by chemical chain termination in vivo. (English)

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12 February 2018

author

Peter Leadlay

series ordinal

3

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12 February 2018

Manuela Tosin

object named as

Manuela Tosin

series ordinal

1

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author name string

Luke Smith

series ordinal

2

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12 February 2018

language of work or name

English

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publication date

24 October 2011

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12 February 2018

Angewandte Chemie International Edition

published in

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volume

50

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12 February 2018

page(s)

11930-11933

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12 February 2018

issue

50

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12 February 2018

The enzymology of polyether biosynthesis

cites work

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201106323

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Polyether ionophores: broad-spectrum and promising biologically active molecules for the control of drug-resistant bacteria and parasites

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Identification of selective inhibitors of cancer stem cells by high-throughput screening

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Accumulation of an E,E,E-triene by the monensin-producing polyketide synthase when oxidative cyclization is blocked

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A complete gene cluster from Streptomyces nanchangensis NS3226 encoding biosynthesis of the polyether ionophore nanchangmycin

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Insights into polyether biosynthesis from analysis of the nigericin biosynthetic gene cluster in Streptomyces sp. DSM4137.

21 January 2018

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Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization

21 January 2018

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Evidence that a novel thioesterase is responsible for polyketide chain release during biosynthesis of the polyether ionophore monensin.

21 January 2018

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Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201106323

Analysis of specific mutants in the lasalocid gene cluster: evidence for enzymatic catalysis of a disfavoured polyether ring closure

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201106323

Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensis.

21 January 2018

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Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening

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Epoxide hydrolase Lsd19 for polyether formation in the biosynthesis of lasalocid A: direct experimental evidence on polyene-polyepoxide hypothesis in polyether biosynthesis

21 January 2018

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Intriguing substrate tolerance of epoxide hydrolase Lsd19 involved in biosynthesis of the ionophore antibiotic lasalocid A.

21 January 2018

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Malonyl carba(dethia)- and malonyl oxa(dethia)-coenzyme A as tools for trapping polyketide intermediates.

21 January 2018

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Synthetic chain terminators off-load intermediates from a type I polyketide synthase

21 January 2018

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In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines.

21 January 2018

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Engineering biodiversity with type II polyketide synthase genes

21 January 2018

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Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ANIE.201106323

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12 February 2018

PubMed ID

22025396

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12 February 2018