(Q48555497)

12 February 2018

title

The Walter B. Cannon Physiology in Perspective Lecture, 2007. ATP-sensitive K+ channels and disease: from molecule to malady (English)

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12 February 2018

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Frances M Ashcroft

1

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12 February 2018

publication date

24 July 2007

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12 February 2018

American Journal of Physiology - Endocrinology and Metabolism

published in

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12 February 2018

volume

293

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12 February 2018

issue

4

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12 February 2018

page(s)

E880-9

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12 February 2018

Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion

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Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.

21 January 2018

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ATP-sensitive potassium channelopathies: focus on insulin secretion

21 January 2018

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Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells

21 January 2018

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Electrophysiology of the pancreatic beta-cell

21 January 2018

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Glucoreceptor mechanisms and the control of insulin release and biosynthesis

21 January 2018

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Activating mutations in the ABCC8 gene in neonatal diabetes mellitus

21 January 2018

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K(ATP) channels: linker between phospholipid metabolism and excitability

21 January 2018

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The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

21 January 2018

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Hyperinsulinism in infancy: from basic science to clinical disease.

21 January 2018

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Intracellular ADP activates K+ channels that are inhibited by ATP in an insulin-secreting cell line

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects

21 January 2018

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Anionic phospholipids activate ATP-sensitive potassium channels

21 January 2018

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Sarcolemmal K(ATP) channels: what do we really know?

21 January 2018

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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

21 January 2018

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Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes.

21 January 2018

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Glucokinase (GCK) mutations in hyper- and hypoglycemia: Maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

21 January 2018

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Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

21 January 2018

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Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA

21 January 2018

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Sulphonylurea action revisited: the post-cloning era.

21 January 2018

1 reference

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The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Focus on Kir6.2: a key component of the ATP-sensitive potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Activating mutations in Kir6.2 and neonatal diabetes: new clinical syndromes, new scientific insights, and new therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

D-Glucose inhibits potassium efflux from pancreatic islet cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Significance of ionic fluxes and changes in membrane potential for stimulus-secretion coupling in pancreatic B-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Cardiac KATP channels in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Overlapping distribution of K(ATP) channel-forming Kir6.2 subunit and the sulfonylurea receptor SUR1 in rodent brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Tolerance for ATP-insensitive K(ATP) channels in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Targeted Overactivity of β Cell KATP Channels Induces Profound Neonatal Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Hyperinsulinism induced by targeted suppression of beta cell KATP channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Activation of the ATP-sensitive K+ channel by long chain acyl-CoA. A role in modulation of pancreatic beta-cell glucose sensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Differential nucleotide regulation of KATP channels by SUR1 and SUR2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

An ATP-binding mutation (G334D) in KCNJ11 is associated with a sulfonylurea-insensitive form of developmental delay, epilepsy, and neonatal diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

C-terminal tails of sulfonylurea receptors control ADP-induced activation and diazoxide modulation of ATP-sensitive K(+) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Roles of KATP channels as metabolic sensors in acute metabolic changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Abnormalities of pancreatic islets by targeted expression of a dominant-negative KATP channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

KATP channels as molecular sensors of cellular metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Adenosine diphosphate as an intracellular regulator of insulin secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

ATP-regulated K+ channels in cardiac muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

A heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Functional effects of KCNJ11 mutations causing neonatal diabetes: enhanced activation by MgATP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Functional effects of mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), causing neonatal diabetes, and response to sulfonylurea therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Kir6.2 polymorphisms sensitize beta-cell ATP-sensitive potassium channels to activation by acyl CoAs: a possible cellular mechanism for increased susceptibility to type 2 diabetes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Glucose dependent K+-channels in pancreatic beta-cells are regulated by intracellular ATP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in while Caucasian subjects or evidence of abnormal function when expressed in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Molecular etiologies of MODY and other early-onset forms of diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Mutations at the same residue (R50) of Kir6.2 (KCNJ11) that cause neonatal diabetes produce different functional effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

A novel mutation causing DEND syndrome: a treatable channelopathy of pancreas and brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Membrane phospholipid control of nucleotide sensitivity of KATP channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

A genome-wide association study identifies novel risk loci for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Functional effects of naturally occurring KCNJ11 mutations causing neonatal diabetes on cloned cardiac KATP channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Identification of a functionally important negatively charged residue within the second catalytic site of the SUR1 nucleotide-binding domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

A Kir6.2 mutation causing neonatal diabetes impairs electrical activity and insulin secretion from INS-1 beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Signaling in channel/enzyme multimers: ATPase transitions in SUR module gate ATP-sensitive K+ conductance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Glibenclamide treatment in permanent neonatal diabetes mellitus due to an activating mutation in Kir6.2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Subunit stoichiometry of the pancreatic β-cell ATP-sensitive K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Improved motor development and good long-term glycaemic control with sulfonylurea treatment in a patient with the syndrome of intermediate developmental delay, early-onset generalised epilepsy and neonatal diabetes associated with the V59M mutation i

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Intracellular ATP directly blocks K+ channels in pancreatic B-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

Glucose-induced decrease in Rb+ permeability in pancreatic β cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00348.2007

10.1152/AJPENDO.00348.2007

21 January 2018

Identifiers

DOI

1 reference

12 February 2018

1 reference

12 February 2018