(Q48571747)

http://europepmc.org/abstract/MED/22496568

12 February 2018

title

Lysosomal dysfunction in a mouse model of Sandhoff disease leads to accumulation of ganglioside-bound amyloid-β peptide. (English)

1 reference

http://europepmc.org/abstract/MED/22496568

12 February 2018

1 reference

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6622109&resulttype=core&format=json

15 May 2020

Joseph Buxbaum

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6622109&resulttype=core&format=json

15 May 2020

author name string

Serene Keilani

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6622109&resulttype=core&format=json

15 May 2020

Yi Lun

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6622109&resulttype=core&format=json

15 May 2020

Anthony C Stevens

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6622109&resulttype=core&format=json

15 May 2020

Hadis N Williams

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6622109&resulttype=core&format=json

15 May 2020

Eric R Sjoberg

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6622109&resulttype=core&format=json

15 May 2020

Richie Khanna

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6622109&resulttype=core&format=json

15 May 2020

Kenneth J Valenzano

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6622109&resulttype=core&format=json

15 May 2020

Katsuhiko Yanagisawa

10

1 reference

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15 May 2020

David J Lockhart

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6622109&resulttype=core&format=json

15 May 2020

Brandon A Wustman

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6622109&resulttype=core&format=json

15 May 2020

Sam Gandy

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6622109&resulttype=core&format=json

15 May 2020

language of work or name

English

0 references

publication date

1 April 2012

1 reference

http://europepmc.org/abstract/MED/22496568

12 February 2018

published in

Journal of Neuroscience

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6622109&resulttype=core&format=json

15 May 2020

volume

32

1 reference

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15 May 2020

issue

15

1 reference

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15 May 2020

page(s)

5223-5236

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6622109&resulttype=core&format=json

Biochemical consequences of mutations causing the GM2 gangliosidoses

15 May 2020

cites work

1 reference

12 December 2020

Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease

1 reference

12 December 2020

Correlation between Abetax-40-, Abetax-42-, and Abetax-43-containing amyloid plaques and cognitive decline

1 reference

12 December 2020

Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease

1 reference

12 December 2020

The neuropathogenic contributions of lysosomal dysfunction

1 reference

12 December 2020

Alzheimer's disease is a synaptic failure

1 reference

12 December 2020

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

1 reference

12 December 2020

Neuronal accumulation of alpha- and beta-synucleins in the brain of a GM2 gangliosidosis mouse model

1 reference

12 December 2020

Spatial and temporal distribution of intracellular free cholesterol in brains of a Niemann-Pick type C mouse model showing hyperphosphorylated tau protein. Implications for Alzheimer's disease

1 reference

12 December 2020

Endocytic trafficking of glycosphingolipids in sphingolipid storage diseases

1 reference

12 December 2020

Cholesterol and Tau Protein - Findings in Alzheimer’s and Niemann Pick C’s Disease

1 reference

12 December 2020

Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport

1 reference

12 December 2020

Aberrant phosphorylation of alpha-synuclein in human Niemann-Pick type C1 disease

1 reference

12 December 2020

A seed for Alzheimer amyloid in the brain.

1 reference

12 December 2020

Glycosphingolipids in endocytic membrane transport

1 reference

12 December 2020

Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein

1 reference

12 December 2020

Tissue processing prior to protein analysis and amyloid-beta quantitation.

1 reference

12 December 2020

ELISA method for measurement of amyloid-beta levels.

1 reference

12 December 2020

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

1 reference

12 December 2020

Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

1 reference

12 December 2020

Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

1 reference

12 December 2020

Alzheimer's disease beta-amyloid peptides are released in association with exosomes

1 reference

12 December 2020

Autophagy, amyloidogenesis and Alzheimer disease

1 reference

12 December 2020

Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease--a review

1 reference

12 December 2020

Neurodegenerative lysosomal disorders: a continuum from development to late age.

1 reference

12 December 2020

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

1 reference

12 December 2020

GM1 gangliosidosis: review of clinical, molecular, and therapeutic aspects.

1 reference

12 December 2020

Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

1 reference

12 December 2020

Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid beta-protein fibrillogenesis.

1 reference

12 December 2020

Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila

1 reference

12 December 2020

Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy

1 reference

12 December 2020

The late stages of autophagy: how does the end begin?

1 reference

12 December 2020

Mitotic epitopes are incorporated into age-dependent neurofibrillary tangles in Niemann-Pick disease type C.

1 reference

12 December 2020

Multi-system disorders of glycosphingolipid and ganglioside metabolism

1 reference

12 December 2020

Macroautophagy is not directly involved in the metabolism of amyloid precursor protein

1 reference

12 December 2020

Endolysosomal calcium regulation and disease

1 reference

12 December 2020

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

1 reference

12 December 2020

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

1 reference

12 December 2020

Gamma-secretase-dependent amyloid-beta is increased in Niemann-Pick type C: a cross-sectional study

1 reference

12 December 2020

Pathological significance of ganglioside clusters in Alzheimer's disease

1 reference

12 December 2020

Accumulation and distribution of α-synuclein and ubiquitin in the CNS of Gaucher disease mouse models

1 reference

12 December 2020

Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation.

1 reference

12 December 2020

Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration

1 reference

12 December 2020

Lysosomal storage disorders and Parkinson's disease: Gaucher disease and beyond

1 reference

12 December 2020

Comparative lipidomic analysis of mouse and human brain with Alzheimer disease.

1 reference

12 December 2020

Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism

1 reference

12 December 2020

Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein.

1 reference

12 December 2020

Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP).

1 reference

12 December 2020

Dramatically different phenotypes in mouse models of human Tay-Sachs and Sandhoff diseases

1 reference

12 December 2020

Mice lacking both subunits of lysosomal beta-hexosaminidase display gangliosidosis and mucopolysaccharidosis

1 reference

12 December 2020

Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid beta peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiop

1 reference

12 December 2020

Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis

1 reference

12 December 2020

Glycosphingolipid degradation and animal models of GM2-gangliosidoses

1 reference

12 December 2020

10.1523/JNEUROSCI.4860-11.2012

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6622109&resulttype=core&format=json

15 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6622109&resulttype=core&format=json

15 May 2020

1 reference