(Q53270598)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21289194%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

title

Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation (English)

1 reference

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21 January 2020

1 reference

5

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21 January 2020

author name string

Irfan Y Tamboli

1

1 reference

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21 January 2020

Heike Hampel

2

1 reference

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21 January 2020

Nguyen T Tien

3

1 reference

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21 January 2020

Karen Tolksdorf

4

1 reference

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21 January 2020

Paul M Mathews

6

1 reference

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21 January 2020

Paul Saftig

7

1 reference

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21 January 2020

Konrad Sandhoff

8

1 reference

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21 January 2020

Jochen Walter

9

1 reference

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21 January 2020

language of work or name

English

0 references

publication date

1 February 2011

1 reference

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21 January 2020

published in

Journal of Neuroscience

1 reference

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21 January 2020

volume

31

1 reference

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21 January 2020

issue

5

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21 January 2020

page(s)

1837-1849

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Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity.

21 January 2020

cites work

1 reference

12 December 2020

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

1 reference

12 December 2020

Autophagy as a regulated pathway of cellular degradation

1 reference

12 December 2020

Genetic factors in the genesis of Alzheimer's disease

1 reference

12 December 2020

Alzheimer's disease: genes, proteins, and therapy

1 reference

12 December 2020

C-terminal fragment of amyloid precursor protein induces astrocytosis

1 reference

12 December 2020

Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis

1 reference

12 December 2020

The cell biology of Alzheimer's disease: uncovering the secrets of secretases

1 reference

12 December 2020

New frontiers in Alzheimer's disease genetics

1 reference

12 December 2020

A non-amyloidogenic function of BACE-2 in the secretory pathway

1 reference

12 December 2020

Cholesterol, lipid rafts, and disease

1 reference

12 December 2020

Cholesterol in Alzheimer's disease and tauopathy

1 reference

12 December 2020

Secretion and intracellular generation of truncated Abeta in beta-site amyloid-beta precursor protein-cleaving enzyme expressing human neurons

1 reference

12 December 2020

Central nervous system inflammation is a hallmark of pathogenesis in mouse models of GM1 and GM2 gangliosidosis

1 reference

12 December 2020

Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities

1 reference

12 December 2020

Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts

1 reference

12 December 2020

Role for Rab7 in maturation of late autophagic vacuoles

1 reference

12 December 2020

The role of autophagy during the early neonatal starvation period

1 reference

12 December 2020

Autophagy in health and disease: a double-edged sword

1 reference

12 December 2020

Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases

1 reference

12 December 2020

Pathophysiological roles of amyloidogenic carboxy-terminal fragments of the beta-amyloid precursor protein in Alzheimer's disease

1 reference

12 December 2020

Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide

1 reference

12 December 2020

Lipid alterations in the earliest clinically recognizable stage of Alzheimer's disease: implication of the role of lipids in the pathogenesis of Alzheimer's disease

1 reference

12 December 2020

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

1 reference

12 December 2020

Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro

1 reference

12 December 2020

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

1 reference

12 December 2020

Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface

1 reference

12 December 2020

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

1 reference

12 December 2020

Loss of autophagy in the central nervous system causes neurodegeneration in mice

1 reference

12 December 2020

Sphingolipid metabolism diseases

1 reference

12 December 2020

Autophagy and aging: the importance of maintaining "clean" cells

1 reference

12 December 2020

Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications

1 reference

12 December 2020

Autophagy in Niemann-Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defects

1 reference

12 December 2020

Cholesterol accumulation is associated with lysosomal dysfunction and autophagic stress in Npc1 -/- mouse brain

1 reference

12 December 2020

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation

1 reference

12 December 2020

Lysosomal storage diseases as disorders of autophagy

1 reference

12 December 2020

Autophagy, amyloidogenesis and Alzheimer disease

1 reference

12 December 2020

Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer's disease

1 reference

12 December 2020

The role of autophagy in age-related neurodegeneration

1 reference

12 December 2020

Enhanced autophagy and mitochondrial aberrations in murine G(M1)-gangliosidosis

1 reference

12 December 2020

Autophagy in the Pathogenesis of Disease

1 reference

12 December 2020

Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease--a review

1 reference

12 December 2020

LAMP-2: a control step for phagosome and autophagosome maturation

1 reference

12 December 2020

Clearance of mutant aggregate-prone proteins by autophagy.

1 reference

12 December 2020

Direct and potent regulation of gamma-secretase by its lipid microenvironment

1 reference

12 December 2020

JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy

1 reference

12 December 2020

Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

1 reference

12 December 2020

Small molecule enhancers of autophagy for neurodegenerative diseases

1 reference

12 December 2020

Autophagy: a lysosomal degradation pathway with a central role in health and disease

1 reference

12 December 2020

Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid beta-protein fibrillogenesis.

1 reference

12 December 2020

Intracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseases

1 reference

12 December 2020

The pathogenesis of Niemann-Pick type C disease: a role for autophagy?

1 reference

12 December 2020

Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis

1 reference

12 December 2020

Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy

1 reference

12 December 2020

p62 degradation by autophagy: another way for cancer cells to survive under hypoxia.

1 reference

12 December 2020

Early endosomes and endosomal coatomer are required for autophagy

1 reference

12 December 2020

Gangliosides' protection against lysosomal pathology of synucleinopathies

1 reference

12 December 2020

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

1 reference

12 December 2020

Adaptation of neuronal cells to chronic oxidative stress is associated with altered cholesterol and sphingolipid homeostasis and lysosomal function

1 reference

12 December 2020

Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases

1 reference

12 December 2020

mTOR signaling at a glance

1 reference

12 December 2020

BH3-only proteins: the death-puppeteer's wires

1 reference

12 December 2020

1 reference

12 December 2020

3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

1 reference

12 December 2020

Accumulation of autophagosomes after inhibition of hepatocytic protein degradation by vinblastine, leupeptin or a lysosomotropic amine

1 reference

12 December 2020

A mouse B16 melanoma mutant deficient in glycolipids

1 reference

12 December 2020

Paired helical filament tau (PHFtau) in Niemann-Pick type C disease is similar to PHFtau in Alzheimer's disease

1 reference

12 December 2020

Mechanisms of neuronal degeneration in Alzheimer's disease

1 reference

12 December 2020

Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations

1 reference

12 December 2020

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein.

1 reference

12 December 2020

Effect of a carboxy-terminal fragment of the Alzheimer's amyloid precursor protein on expression of proinflammatory cytokines in rat glial cells

1 reference

12 December 2020

10.1523/JNEUROSCI.2954-10.2011

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21289194%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21289194%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference