(Q46250285)

20 December 2017

http://europepmc.org/abstract/MED/19005074

title

Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis (English)

1 reference

20 December 2017

http://europepmc.org/abstract/MED/19005074

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671640&resulttype=core&format=json

16 May 2020

Ilse Dewachter

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671640&resulttype=core&format=json

Peter Henry St George-Hyslop

16 May 2020

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671640&resulttype=core&format=json

16 May 2020

Jochen Walter

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671640&resulttype=core&format=json

16 May 2020

author name string

Irfan Y Tamboli

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671640&resulttype=core&format=json

16 May 2020

Kai Prager

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671640&resulttype=core&format=json

16 May 2020

Karin M Thelen

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671640&resulttype=core&format=json

16 May 2020

Claus U Pietrzik

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671640&resulttype=core&format=json

16 May 2020

Sangram S Sisodia

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671640&resulttype=core&format=json

16 May 2020

Michael T Heneka

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671640&resulttype=core&format=json

16 May 2020

Mikhail A Filippov

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671640&resulttype=core&format=json

16 May 2020

Ulrike Müller

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671640&resulttype=core&format=json

16 May 2020

Fred van Leuven

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671640&resulttype=core&format=json

16 May 2020

Dieter Lütjohann

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671640&resulttype=core&format=json

16 May 2020

Bart De Strooper

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671640&resulttype=core&format=json

16 May 2020

language of work or name

English

0 references

publication date

1 November 2008

1 reference

20 December 2017

http://europepmc.org/abstract/MED/19005074

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671640&resulttype=core&format=json

16 May 2020

volume

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671640&resulttype=core&format=json

16 May 2020

issue

46

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671640&resulttype=core&format=json

16 May 2020

page(s)

12097-12106

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671640&resulttype=core&format=json

Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein

16 May 2020

cites work

1 reference

12 December 2020

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

1 reference

12 December 2020

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

12 December 2020

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

1 reference

12 December 2020

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

12 December 2020

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

12 December 2020

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

1 reference

12 December 2020

Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway.

1 reference

12 December 2020

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

1 reference

12 December 2020

LDL downregulates CYP51 in porcine vascular endothelial cells and in the arterial wall through a sterol regulatory element binding protein-2-dependent mechanism.

1 reference

12 December 2020

Alzheimer's disease: genes, proteins, and therapy

1 reference

12 December 2020

Phosphorylation regulates intracellular trafficking of beta-secretase

1 reference

12 December 2020

CNS synaptogenesis promoted by glia-derived cholesterol

1 reference

12 December 2020

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

1 reference

12 December 2020

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

1 reference

12 December 2020

Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.

1 reference

12 December 2020

Lipoprotein receptors in the nervous system

1 reference

12 December 2020

No endogenous A beta production in presenilin-deficient fibroblasts.

1 reference

12 December 2020

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

1 reference

12 December 2020

Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms

1 reference

12 December 2020

Role of glia in synapse development.

1 reference

12 December 2020

The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing

1 reference

12 December 2020

Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein.

1 reference

12 December 2020

Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein

1 reference

12 December 2020

The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery

1 reference

12 December 2020

The role of the carboxyl-terminal fragments of amyloid precursor protein in Alzheimer's disease

1 reference

12 December 2020

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

1 reference

12 December 2020

Autosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimer's amyloid beta precursor protein

1 reference

12 December 2020

Cholesterol homeostasis and function in neurons of the central nervous system

1 reference

12 December 2020

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

1 reference

12 December 2020

Potential Role of Endogenous and Exogenous Amyloid-Beta Binding Molecules in the Pathogenesis, Diagnosis, and Treatment of Alzheimer Disease

1 reference

12 December 2020

The genetics of adult-onset neuropsychiatric disease: complexities and conundra?

1 reference

12 December 2020

Apolipoprotein E, amyloid, and Alzheimer disease

1 reference

12 December 2020

Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation

1 reference

12 December 2020

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

1 reference

12 December 2020

FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein.

1 reference

12 December 2020

Gamma-secretase: proteasome of the membrane?

1 reference

12 December 2020

Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.

1 reference

12 December 2020

Intramembrane proteolysis: theme and variations.

1 reference

12 December 2020

Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

1 reference

12 December 2020

Intracellular retention of caveolin 1 in presenilin-deficient cells

1 reference

12 December 2020

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

1 reference

12 December 2020

Pathophysiological roles of amyloidogenic carboxy-terminal fragments of the beta-amyloid precursor protein in Alzheimer's disease

1 reference

12 December 2020

Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide

1 reference

12 December 2020

Structure and physiologic function of the low-density lipoprotein receptor

1 reference

12 December 2020

ELISA method for measurement of amyloid-beta levels.

1 reference

12 December 2020

High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial

1 reference

12 December 2020

A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein

1 reference

12 December 2020

Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner.

1 reference

12 December 2020

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

1 reference

12 December 2020

Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation

1 reference

12 December 2020

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

1 reference

12 December 2020

Protein sensors for membrane sterols

1 reference

12 December 2020

A partial failure of membrane protein turnover may cause Alzheimer's disease: a new hypothesis.

1 reference

12 December 2020

Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface

1 reference

12 December 2020

Presenilin/gamma-secretase activity regulates protein clearance from the endocytic recycling compartment.

1 reference

12 December 2020

Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40.

1 reference

12 December 2020

The nucleation growth and reversibility of Amyloid-beta deposition in vivo.

1 reference

12 December 2020

GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide.

1 reference

12 December 2020

Presenilin diversifies its portfolio.

1 reference

12 December 2020

Receptor-Mediated Control of Cholesterol Metabolism

1 reference

12 December 2020

The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

1 reference

12 December 2020

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

1 reference

12 December 2020

Presenilin: running with scissors in the membrane

1 reference

12 December 2020

Building gamma-secretase: the bits and pieces

1 reference

12 December 2020

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

1 reference

12 December 2020

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

1 reference

12 December 2020

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

12 December 2020

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

12 December 2020

Hyperaccumulation of FAD-linked presenilin 1 variants in vivo.

1 reference

12 December 2020

Neuronal expression of beta-amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains.

1 reference

12 December 2020

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

12 December 2020

Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice

1 reference

12 December 2020

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

1 reference

12 December 2020

Effects of PS1 deficiency on membrane protein trafficking in neurons

1 reference

12 December 2020

10.1523/JNEUROSCI.2635-08.2008

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671640&resulttype=core&format=json

16 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671640&resulttype=core&format=json

16 May 2020

1 reference