(Q35844774)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15272268%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

review article

1 reference

title

Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15272268%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15272268%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

author name string

Edward H Koo

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15272268%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

language of work or name

English

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publication date

1 July 2004

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31 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15272268%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

volume

10 Suppl

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15272268%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

page(s)

S26-33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15272268%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nm1065

31 December 2019

exact match

0 references

cites work

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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Alzheimer's disease is a synaptic failure

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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7 January 2021

Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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7 January 2021

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

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7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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7 January 2021

Identification of signal peptide peptidase, a presenilin-type aspartic protease

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7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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7 January 2021

Intramembrane proteolysis by presenilin and presenilin-like proteases

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7 January 2021

Reconstitution of gamma-secretase activity

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7 January 2021

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

7 January 2021

The role of presenilin cofactors in the gamma-secretase complex

1 reference

7 January 2021

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

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7 January 2021

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

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7 January 2021

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

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7 January 2021

Mechanisms of neuronal degeneration in Alzheimer's disease

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7 January 2021

Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease.

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7 January 2021

Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome

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7 January 2021

Molecular mapping of Alzheimer-type dementia in Down's syndrome.

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7 January 2021

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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7 January 2021

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

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7 January 2021

ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.

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7 January 2021

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

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7 January 2021

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.

1 reference

7 January 2021

Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.

1 reference

7 January 2021

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

1 reference

7 January 2021

Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP.

1 reference

7 January 2021

Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice

1 reference

7 January 2021

Presenilin-mediated modulation of capacitative calcium entry

1 reference

7 January 2021

Presenilin mutations and calcium signaling defects in the nervous and immune systems

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7 January 2021

Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease

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7 January 2021

Presenilin-1 deficiency impairs glutamate-evoked intracellular calcium responses in neurons

1 reference

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

7 January 2021

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

1 reference

7 January 2021

Notch signaling: cell fate control and signal integration in development

1 reference

7 January 2021

The role of notch in promoting glial and neural stem cell fates

1 reference

7 January 2021

Requirement of Notch in adulthood for neurological function and longevity.

1 reference

7 January 2021

Notch is required for long-term memory in Drosophila

1 reference

7 January 2021

Learning and memory deficits in Notch mutant mice.

1 reference

7 January 2021

Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces

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7 January 2021

Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells

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7 January 2021

The role of Notch and Rho GTPase signaling in the control of dendritic development

1 reference

7 January 2021

Notch1 inhibits neurite outgrowth in postmitotic primary neurons.

1 reference

7 January 2021

Contact-dependent inhibition of cortical neurite growth mediated by notch signaling

1 reference

7 January 2021

Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease.

1 reference

7 January 2021

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

7 January 2021

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

7 January 2021

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

1 reference

7 January 2021

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

1 reference

7 January 2021

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

7 January 2021

Presenilin-1 mutation L271V results in altered exon 8 splicing and Alzheimer's disease with non-cored plaques and no neuritic dystrophy.

1 reference

7 January 2021

A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.

1 reference

7 January 2021

Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression

1 reference

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

7 January 2021

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

1 reference

7 January 2021

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

1 reference

7 January 2021

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

7 January 2021

Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription

1 reference

7 January 2021

The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

1 reference

7 January 2021

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

1 reference

7 January 2021

The transcriptional activity of the APP intracellular domain-Fe65 complex is inhibited by activation of the NF-kappaB pathway

1 reference

7 January 2021

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

1 reference

7 January 2021

Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

1 reference

7 January 2021

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

1 reference

7 January 2021

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

1 reference

7 January 2021

Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice

1 reference

7 January 2021

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

1 reference

7 January 2021

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

1 reference

7 January 2021

Alzheimer's disease: a dysfunction of the amyloid precursor protein(1).

1 reference

7 January 2021

An etiological role of amyloidogenic carboxyl-terminal fragments of the beta-amyloid precursor protein in Alzheimer's disease.

1 reference

7 January 2021

Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor.

1 reference

7 January 2021

The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.

1 reference

7 January 2021

A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

1 reference

7 January 2021

Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes

1 reference

7 January 2021

The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage

1 reference

7 January 2021

Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC)

1 reference

7 January 2021

The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments

1 reference

7 January 2021

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

1 reference

7 January 2021

Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor

1 reference

7 January 2021

Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage

1 reference

7 January 2021

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

1 reference

7 January 2021

Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

1 reference

7 January 2021

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

1 reference

7 January 2021

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

1 reference

7 January 2021

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

1 reference

7 January 2021

Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling

1 reference

7 January 2021

Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase

1 reference

7 January 2021

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

1 reference

7 January 2021

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

7 January 2021

Gamma-secretase: proteasome of the membrane?

1 reference

7 January 2021

Gene targeting reveals multiple essential functions of the neuregulin signaling system during development of the neuroendocrine and nervous systems.

1 reference

7 January 2021

Netrins and netrin receptors

1 reference

7 January 2021

Neurotrophins and their receptors: a convergence point for many signalling pathways

1 reference

7 January 2021

Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease.

1 reference

7 January 2021

P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp

1 reference

7 January 2021

Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway

1 reference

7 January 2021

Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREB-binding protein

1 reference

7 January 2021

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

1 reference

7 January 2021

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

1 reference

7 January 2021

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

1 reference

7 January 2021

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

1 reference

7 January 2021

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

1 reference

7 January 2021

Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

1 reference

7 January 2021

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

1 reference

7 January 2021

Identifiers

DOI

10.1038/NM1065

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15272268%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

1 reference