(Q42496750)

1 November 2017

Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6773081&resulttype=core&format=json

12 May 2020

author name string

R Siman

1

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12 May 2020

A G Reaume

2

1 reference

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12 May 2020

M J Savage

3

1 reference

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12 May 2020

S Trusko

4

1 reference

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12 May 2020

Y G Lin

5

1 reference

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12 May 2020

R W Scott

6

1 reference

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12 May 2020

D G Flood

7

1 reference

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12 May 2020

language of work or name

English

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publication date

1 December 2000

1 reference

1 November 2017

Journal of Neuroscience

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12 May 2020

volume

20

1 reference

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12 May 2020

page(s)

8717-8726

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12 May 2020

issue

23

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describes a project that uses

12 May 2020

ImageQuant

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11 June 2022

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inferred from PubMed Central ID database lookup

cites work

Calpain inhibitor I increases beta-amyloid peptide production by inhibiting the degradation of the substrate of gamma-secretase. Evidence that substrate availability limits beta-amyloid peptide production

1 reference

12 December 2020

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

12 December 2020

Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture

1 reference

12 December 2020

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

12 December 2020

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

1 reference

12 December 2020

Excitotoxic neurodegeneration in Alzheimer disease. New hypothesis and new therapeutic strategies

1 reference

12 December 2020

Cerebral amyloid induces aberrant axonal sprouting and ectopic terminal formation in amyloid precursor protein transgenic mice.

1 reference

12 December 2020

The calcium-activated protease calpain I and ischemia-induced neurodegeneration

1 reference

12 December 2020

Microglial response to amyloid plaques in APPsw transgenic mice.

1 reference

12 December 2020

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1 reference

12 December 2020

Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo

1 reference

12 December 2020

Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression.

1 reference

12 December 2020

Evidence that Wallerian degeneration and localized axon degeneration induced by local neurotrophin deprivation do not involve caspases

1 reference

12 December 2020

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

1 reference

12 December 2020

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides

1 reference

12 December 2020

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

12 December 2020

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

12 December 2020

Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol.

1 reference

12 December 2020

Light and electron microscopic localization of presenilin-1 in primate brain.

1 reference

12 December 2020

Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell death

1 reference

12 December 2020

Simultaneous Degradation of αII- and βII-Spectrin by Caspase 3 (CPP32) in Apoptotic Cells

1 reference

12 December 2020

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

12 December 2020

Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1

1 reference

12 December 2020

Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization

1 reference

12 December 2020

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

12 December 2020

Mechanisms of neuronal degeneration in Alzheimer's disease

1 reference

12 December 2020

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1 reference

12 December 2020

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

1 reference

12 December 2020

Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3

1 reference

12 December 2020

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

1 reference

12 December 2020

Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease.

1 reference

12 December 2020

Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis.

1 reference

12 December 2020

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

12 December 2020

Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester.

1 reference

12 December 2020

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

12 December 2020

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.

1 reference

12 December 2020

Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain.

1 reference

12 December 2020

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

12 December 2020

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

1 reference

12 December 2020

Degeneration in vivo of rat hippocampal neurons by wild-type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer.

1 reference

12 December 2020

G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP.

1 reference

12 December 2020

A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1.

1 reference

12 December 2020

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

1 reference

12 December 2020

Activation of neuronal caspase-3 by intracellular accumulation of wild-type Alzheimer amyloid precursor protein.

1 reference

12 December 2020

Alzheimer's disease: genetic studies and transgenic models

1 reference

12 December 2020

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

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12 December 2020

Familial Alzheimer's chromosome 14 mutations.

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12 December 2020

Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster

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12 December 2020

Intraneuronal Abeta42 accumulation in human brain.

1 reference

12 December 2020

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

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12 December 2020

Constitutive expression of the machinery for programmed cell death

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12 December 2020

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

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12 December 2020

Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.

1 reference

12 December 2020

Immunolocalization of caspase proteolysis in situ: evidence for widespread caspase-mediated apoptosis of neurons and glia in the postnatal rat brain

1 reference

12 December 2020

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

12 December 2020

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1 reference

12 December 2020

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

1 reference

12 December 2020

Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.

1 reference

12 December 2020

Amyloid, the presenilins and Alzheimer's disease

1 reference

12 December 2020

Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation.

1 reference

12 December 2020

Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.

1 reference

12 December 2020

Caspases: enemies within

1 reference

12 December 2020

Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway

1 reference

12 December 2020

Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease.

1 reference

12 December 2020

Accumulation of murine amyloidbeta42 in a gene-dosage-dependent manner in PS1 'knock-in' mice.

1 reference

12 December 2020

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

12 December 2020

Calpain and caspase: can you tell the difference?

1 reference

12 December 2020

Protein topology of presenilin 1

1 reference

12 December 2020

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

1 reference

12 December 2020

Rank-order of potencies for inhibition of the secretion of abeta40 and abeta42 suggests that both are generated by a single gamma-secretase

1 reference

12 December 2020

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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12 December 2020

Characterization of human presenilin 1 transgenic rats: increased sensitivity to apoptosis in primary neuronal cultures.

1 reference

12 December 2020

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1 reference

12 December 2020

Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequence.

1 reference

12 December 2020

10.1523/JNEUROSCI.20-23-08717.2000

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6773081&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6773081&resulttype=core&format=json

12 May 2020

1 reference