(Q28182185)

English

The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments

scientific article (publication date: 5 September 2003)

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scholarly article

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The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments (English)

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Dennis J. Selkoe

2

object named as

Dennis J Selkoe

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author name string

Matthew J LaVoie

1

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language of work or name

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publication date

5 September 2003

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Journal of Biological Chemistry

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278

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34427-37

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36

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

kuzbanian-mediated cleavage of Drosophila Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Processing of the notch ligand delta by the metalloprotease Kuzbanian

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3 genes identify ligand-receptor pairs that may function in neural development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Evidence for a physical interaction between presenilin and Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Subcellular localization and analysis of apparent 180-kDa and 220-kDa proteins of the breast cancer susceptibility gene, BRCA1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

The C-terminal PDZ-ligand of JAGGED1 is essential for cellular transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Repression of activator protein-1-mediated transcriptional activation by the Notch-1 intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Notch-induced proteolysis and nuclear localization of the Delta ligand

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Notch signalling pathway and human diseases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Expression of Notch1 and Jagged1 proteins in acute myeloid leukemia cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing Drosophila wing.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Serrate and wingless cooperate to induce vestigial gene expression and wing formation in Drosophila.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Distinct functions of the Drosophila genes Serrate and Delta revealed by ectopic expression during wing development.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Down-regulation of Delta by proteolytic processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Autonomous and non-autonomous regulation of mammalian neurite development by Notch1 and Delta1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

An activity of Notch regulates JNK signalling and affects dorsal closure in Drosophila.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Notch inhibition of E47 supports the existence of a novel signaling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Identification of a functionally important sequence in the cytoplasmic tail of integrin beta 3 by using cell-permeable peptide analogs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

canoe encodes a novel protein containing a GLGF/DHR motif and functions with Notch and scabrous in common developmental pathways in Drosophila

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302659200

21 January 2018

Identifiers

10.1074/JBC.M302659200

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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