(Q34509753)

2 August 2017

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title

Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease (English)

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2 August 2017

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Glabe C

1

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2 August 2017

1 October 2001

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Journal of Molecular Neuroscience

2 August 2017

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2 August 2017

17

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2 August 2017

2

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2 August 2017

137-145

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https://scigraph.springernature.com/pub.10.1385/jmn:17:2:137

2 August 2017

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cites work

Kunitz protease inhibitor-containing amyloid beta protein precursor immunoreactivity in Alzheimer's disease

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12 December 2020

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

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12 December 2020

Ultrastructural localization of Alzheimer amyloid beta/A4 protein precursor in the cytoplasm of neurons and senile plaque-associated astrocytes

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12 December 2020

Dystrophic neurites around amyloid plaques of human patients with Gerstmann-Sträussler-Scheinker disease contain ubiquitinated inclusions

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12 December 2020

The immunopathology of Alzheimer's disease and some related disorders

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12 December 2020

Radical AGEing in Alzheimer's disease

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12 December 2020

Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein

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12 December 2020

Ultrastructural localization of argyrophilic substances in diffuse plaques of Alzheimer-type dementia demonstrated by methenamine silver staining

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12 December 2020

Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease

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12 December 2020

Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation

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12 December 2020

Amyloid beta-protein precursor accumulates in dystrophic neurites of senile plaques in Alzheimer-type dementia

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12 December 2020

Transmissible and non-transmissible amyloidoses: autocatalytic post-translational conversion of host precursor proteins to beta-pleated sheet configurations

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12 December 2020

Amyloid precursor protein and ubiquitin immunoreactivity in dystrophic axons is not unique to Alzheimer's disease

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12 December 2020

An etiological role of amyloidogenic carboxyl-terminal fragments of the beta-amyloid precursor protein in Alzheimer's disease.

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12 December 2020

Intraneuronal Abeta42 accumulation in human brain.

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12 December 2020

Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein.

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12 December 2020

Altered structural proteins in plaques and tangles: what do they tell us about the biology of Alzheimer's disease?

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12 December 2020

Advanced Maillard reaction end products, free radicals, and protein oxidation in Alzheimer's disease

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12 December 2020

Surfactant properties of Alzheimer's A beta peptides and the mechanism of amyloid aggregation.

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12 December 2020

Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis

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12 December 2020

Antibodies to non-beta regions of the beta-amyloid precursor protein detect a subset of senile plaques

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12 December 2020

The lysosomal system in neurons. Involvement at multiple stages of Alzheimer's disease pathogenesis

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12 December 2020

Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein.

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12 December 2020

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

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12 December 2020

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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12 December 2020

Generation of Alzheimer amyloid beta peptide through nonspecific proteolysis

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12 December 2020

Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease

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12 December 2020

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

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12 December 2020

beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease

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12 December 2020

Complement activation in amyloid plaques in Alzheimer's dementia.

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12 December 2020

Immunoelectron microscopic study of synaptic pathology in Alzheimer's disease

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12 December 2020

Involvement of free oxygen radicals in beta-amyloidosis: an hypothesis

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12 December 2020

Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease

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12 December 2020

Neuritic plaque amyloid in Alzheimer's disease is highly racemized

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12 December 2020

Neuroimmune mechanisms in Alzheimer disease pathogenesis

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12 December 2020

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs

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12 December 2020

Inflammation as a pathogenic mechanism in Alzheimer's disease.

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12 December 2020

Alzheimer's disease or Alzheimer's diseases? Clues from molecular epidemiology.

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12 December 2020

Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease

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12 December 2020

Hydrogen peroxide mediates amyloid beta protein toxicity

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12 December 2020

Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer's disease

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12 December 2020

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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12 December 2020

The pathobiology of Alzheimer's disease

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12 December 2020

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

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12 December 2020

Early accumulation of heparan sulfate in neurons and in the beta-amyloid protein-containing lesions of Alzheimer's disease and Down's syndrome

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12 December 2020

A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

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12 December 2020

Solution Structures of β Peptide and Its Constituent Fragments: Relation to Amyloid Deposition

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12 December 2020

Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

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12 December 2020

Hirano bodies and related neuronal inclusions

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12 December 2020

Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease

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12 December 2020

Advanced glycation end products contribute to amyloidosis in Alzheimer disease

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12 December 2020

Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin.

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12 December 2020

Ubiquitin immunocytochemistry in human spongiform encephalopathies.

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12 December 2020

Ultrastructural localization of beta-amyloid, tau, and ubiquitin epitopes in extracellular neurofibrillary tangles

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12 December 2020

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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12 December 2020

Immunohistochemical localization of beta-amyloid precursor protein sequences in Alzheimer and normal brain tissue by light and electron microscopy.

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12 December 2020

The Alzheimer A beta peptide develops protease resistance in association with its polymerization into fibrils.

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12 December 2020

Are advanced glycation end-products associated with amyloidosis in Alzheimer's disease?

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12 December 2020

The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease

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12 December 2020

Calcium and neuronal injury in Alzheimer's disease. Contributions of beta-amyloid precursor protein mismetabolism, free radicals, and metabolic compromise

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12 December 2020

Neuritic involvement within bFGF immunopositive plaques of Alzheimer's disease

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12 December 2020

Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease

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12 December 2020

Prions causing nervous system degeneration

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12 December 2020

Free radicals and degenerative diseases of the nervous system

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12 December 2020

Alzheimer's disease: genes, proteins, and therapy

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12 December 2020

The retinal pigment epithelium: a versatile partner in vision.

1 reference

12 December 2020

Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease.

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12 December 2020

Ultrastructural studies of the cells forming amyloid fibers in classical plaques.

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12 December 2020

Two types of dystrophic neurites in senile plaques of Alzheimer disease and elderly non-demented cases.

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12 December 2020

Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage

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12 December 2020

The risk factors for Alzheimer's disease: a review and a hypothesis

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12 December 2020

Acid phosphatase activity in senile plaques and cerebrospinal fluid of patients with Alzheimer's disease.

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12 December 2020

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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12 December 2020

A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene.

1 reference

12 December 2020

Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, A beta 1-42, in differentiated PC12 cells

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12 December 2020

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

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12 December 2020

Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.

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12 December 2020

Neurochemical studies: an update on Alzheimer's disease

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12 December 2020

Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease.

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12 December 2020

In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease

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12 December 2020

Ubiquitin conjugate immunoreactivity in the brains of scrapie infected mice

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12 December 2020

Endosome-lysosomes, ubiquitin and neurodegeneration.

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12 December 2020

Racemization: its biological significance on neuropathogenesis of Alzheimer's disease

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12 December 2020

Alzheimer's disease. Beta-amyloid precursor protein expression in the nucleus basalis of Meynert

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12 December 2020

Ubiquitin-mediated degradative pathway degrades the extracellular but not the intracellular form of amyloid beta-protein precursor.

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12 December 2020

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

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12 December 2020

Evidence that A beta 42 is the real culprit in Alzheimer's disease.

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12 December 2020

Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins

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12 December 2020

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

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12 December 2020

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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12 December 2020

Intracellular A beta 1-42 aggregates stimulate the accumulation of stable, insoluble amyloidogenic fragments of the amyloid precursor protein in transfected cells.

1 reference

12 December 2020

Identifiers

DOI

10.1385/JMN:17:2:137

1 reference

PubMed ID

11816787

Dimensions Publication ID

2 August 2017

0 references

1 reference

PubMed ID

11816787