(Q48583884)

English

Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma.

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma. (English)

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

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author name string

Timothy M Nywening

1

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

Brian A Belt

2

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

Darren R Cullinan

3

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

Roheena Z Panni

4

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

Booyeon J Han

5

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

Dominic E Sanford

6

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

Ryan C Jacobs

7

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

Jian Ye

8

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

Ankit A Patel

9

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

William E Gillanders

10

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

Ryan C Fields

11

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

David G DeNardo

12

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

William G Hawkins

13

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

Peter Goedegebuure

14

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

David C Linehan

15

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

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publication date

1 December 2017

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

67

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

6

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

1112-1123

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

Cancer Statistics, 2017.

1 reference

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3 July 2018

CXCR2-Dependent Accumulation of Tumor-Associated Neutrophils Regulates T-cell Immunity in Pancreatic Ductal Adenocarcinoma

1 reference

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3 July 2018

Immunotherapy Expands and Maintains the Function of High-Affinity Tumor-Infiltrating CD8 T Cells In Situ

1 reference

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3 July 2018

CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5969359

3 July 2018

Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5969359

3 July 2018

Neutrophils in the Tumor Microenvironment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5969359

3 July 2018

Chemotherapy-induced neutropenia as a prognostic factor in patients with unresectable pancreatic cancer

1 reference

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3 July 2018

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor

1 reference

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CXCR2 Antagonist MK-7123. A Phase 2 Proof-of-Concept Trial for Chronic Obstructive Pulmonary Disease

1 reference

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3 July 2018

CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models.

1 reference

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3 July 2018

Tumor-associated neutrophils as a new prognostic factor in cancer: a systematic review and meta-analysis

1 reference

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3 July 2018

Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis

1 reference

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3 July 2018

Disruption of CXCR2-mediated MDSC tumor trafficking enhances anti-PD1 efficacy.

1 reference

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3 July 2018

Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5969359

3 July 2018

Increased levels of granulocytic myeloid-derived suppressor cells in peripheral blood and tumour tissue of pancreatic cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5969359

3 July 2018

CCR2 deficiency promotes exacerbated chronic erosive neutrophil-dominated chikungunya virus arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5969359

3 July 2018

Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5969359

3 July 2018

A systematic review and meta-analysis on the impact of pre-operative neutrophil lymphocyte ratio on long term outcomes after curative intent resection of solid tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5969359

3 July 2018

Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5969359

3 July 2018

Immunomonitoring and prognostic relevance of neutrophils in clinical trials.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5969359

3 July 2018

Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5969359

3 July 2018

Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5969359

3 July 2018

A multicenter, randomized trial of flat dosing versus intrapatient dose escalation of single-agent carboplatin as first-line chemotherapy for advanced ovarian cancer: an SGCTG (SCOTROC 4) and ANZGOG study on behalf of GCIG

1 reference

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3 July 2018

Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5969359

3 July 2018

Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia

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3 July 2018

Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5969359

3 July 2018

Coordinated regulation of myeloid cells by tumours

1 reference

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3 July 2018

Correlation between the pretherapeutic neutrophil to lymphocyte ratio and the pathologic response to neoadjuvant chemotherapy in patients with advanced esophageal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5969359

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Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth.

1 reference

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3 July 2018

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3 July 2018

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5969359

3 July 2018

T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

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3 July 2018

FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5969359

3 July 2018

Pancreatic ductal adenocarcinoma mice lacking mucin 1 have a profound defect in tumor growth and metastasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5969359

3 July 2018

Overexpression of CXCL5 is associated with poor survival in patients with pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5969359

3 July 2018

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow

1 reference

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Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil response

1 reference

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Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice.

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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14 August 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5969359

14 August 2018

Neutrophil infiltration into human gliomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5969359

14 August 2018

Dynamics of the immune reaction to pancreatic cancer from inception to invasion

1 reference

https://pubmed.ncbi.nlm.nih.gov/29196437

12 December 2020

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inferred from PubMed ID database lookup

Elevated neutrophil to lymphocyte ratio predicts poor prognosis in nasopharyngeal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/29196437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/29196437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of CXCL5 mediates neutrophil infiltration and indicates poor prognosis for hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/29196437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recruitment of a myeloid cell subset (CD11b/Gr1mid) via CCL2/CCR2 promotes the development of colorectal cancer liver metastasis*

1 reference

https://pubmed.ncbi.nlm.nih.gov/29196437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1136/GUTJNL-2017-313738

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 July 2018

http://europepmc.org/abstract/PMC/5969359

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