(Q48637389)

English

Increased Neuronal Endocytosis and Protease Delivery to Early Endosomes in Sporadic Alzheimer’s Disease: Neuropathologic Evidence for a Mechanism of Increased β-Amyloidogenesis

scientific article published on August 15, 1997

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scholarly article

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Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/9236226

Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis (English)

1 reference

Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/9236226

Increased Neuronal Endocytosis and Protease Delivery to Early Endosomes in Sporadic Alzheimer’s Disease: Neuropathologic Evidence for a Mechanism of Increased β-Amyloidogenesis (English)

1 reference

10.1523/JNEUROSCI.17-16-06142.1997

https://api.crossref.org/works/10.1523/JNEUROSCI.17-16-06142.1997

8 November 2024

Alzheimer's disease

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author name string

A. M. Cataldo

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9236226

8 November 2024

J. L. Barnett

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9236226

8 November 2024

C. Pieroni

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9236226

8 November 2024

R. A. Nixon

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9236226

8 November 2024

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publication date

1 August 1997

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Europe PubMed Central

PubMed publication ID

13 February 2018

http://europepmc.org/abstract/MED/9236226

15 August 1997

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9236226

8 November 2024

full work available at URL

https://www.jneurosci.org/content/jneuro/17/16/6142.full.pdf

Portable Document Format

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1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9236226

8 November 2024

http://www.jneurosci.org/cgi/content/abstract/17/16/6142

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9236226

8 November 2024

https://europepmc.org/articles/PMC6568334

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9236226

8 November 2024

https://europepmc.org/articles/PMC6568334?pdf=render

Portable Document Format

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9236226

8 November 2024

https://doi.org/10.1523/jneurosci.17-16-06142.1997

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9236226

8 November 2024

https://syndication.highwire.org/content/doi/10.1523/JNEUROSCI.17-16-06142.1997

1 reference

10.1523/JNEUROSCI.17-16-06142.1997

https://api.crossref.org/works/10.1523/JNEUROSCI.17-16-06142.1997

8 November 2024

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6568334&resulttype=core&format=json

15 May 2020

17

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6568334&resulttype=core&format=json

15 May 2020

16

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6568334&resulttype=core&format=json

15 May 2020

6142-6151

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6568334&resulttype=core&format=json

15 May 2020

Alzheimer's disease amyloid beta-clipping enzyme (APP secretase): identification, purification, and characterization of the enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The lysosomal system in neuronal cell death: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The two mannose 6-phosphate receptors have almost identical subcellular distributions in U937 monocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An immunohistochemical study of cathepsin E in Alzheimer-type dementia brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Candidate .gamma.-Secretases in the Generation of the Carboxyl Terminus of the Alzheimer's Disease .beta.A4 Amyloid: Possible Involvement of Cathepsin D

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The endosomal-lysosomal system of neurons: new roles

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid precursor protein is enriched in axolemma and periaxolemmal-myelin and associated clathrin-coated vesicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

rab5 controls early endosome fusion in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphomannosyl-enzyme receptors in rat liver. Subcellular distribution and role in intracellular transport of lysosomal enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axonal and dendritic endocytic pathways in cultured neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The involvement of the small GTP-binding protein Rab5a in neuronal endocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the metabolism of apolipoprotein E and the Alzheimer diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sorting of mannose 6-phosphate receptors and lysosomal membrane proteins in endocytic vesicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cleavage of parathyroid hormone in macrophage endosomes illustrates a novel pathway for intracellular processing of proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrolases in intracellular compartments of rat liver cells. Evidence for selective activation and/or delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Demonstration of amyloid beta-protein secretion in a mouse neuronal cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free radicals, proteolysis, and the degeneration of neurons in Alzheimer disease: how essential is the beta-amyloid link?

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport of surface mannose 6-phosphate receptor to the Golgi complex in cultured human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of newly synthesized lysosomal enzymes in the endocytic pathway of normal rat kidney cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of neurofilament proteins by purified human brain cathepsin D.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The endosomal concentration of a mannose 6-phosphate receptor is unchanged in the absence of ligand synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological functions of endosomal proteolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mr 46,000 mannose 6-phosphate specific receptor: its role in targeting of lysosomal enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrolysis of amyloid precursor protein-derived peptides by cysteine proteinases and extracts of rat brain clathrin-coated vesicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mannose 6-phosphate receptor and the biogenesis of lysosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic generation of the amino terminus of the beta-amyloid peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mannose-6-phosphate receptors for lysosomal enzymes cycle between the Golgi complex and endosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of the Pre‐β‐amyloid Protein by Cathepsin d is Enhanced by a Familial Alzheimer's Disease Mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

46-kDa mannose 6-phosphate-specific receptor: biosynthesis, processing, subcellular location and topology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rab5a is a common component of the apical and basolateral endocytic machinery in polarized epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysosomal enzymes and their receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A non-autophagic pathway for diversion of ER secretory proteins to lysosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibodies against the cytoplasmic tail can differentiate between the quaternary forms of theMr46000 mannose 6-phosphate receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of β-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mannose 6-phosphate receptors and lysosomal enzyme targeting

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Meeting of the apical and basolateral endocytic pathways of the Madin-Darby canine kidney cell in late endosomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mannose 6-phosphate receptor dependent secretion of lysosomal enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production of the Alzheimer's beta-amyloid peptide by C6 glioma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prelysosomal and lysosomal connections between autophagy and endocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9236226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.17-16-06142.1997

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6568334&resulttype=core&format=json

15 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6568334&resulttype=core&format=json

15 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6568334&resulttype=core&format=json

15 May 2020

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