(Q48649157)

13 February 2018

title

Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide. (English)

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13 February 2018

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4

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13 February 2018

Cinthia Farina

7

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13 February 2018

author name string

Emanuela Colombo

1

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13 February 2018

Marco Di Dario

2

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13 February 2018

Eleonora Capitolo

3

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Jia Newcombe

5

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13 February 2018

Gianvito Martino

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publication date

15 July 2014

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13 February 2018

published in

Annals of Neurology

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13 February 2018

volume

76

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13 February 2018

issue

3

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13 February 2018

page(s)

325-337

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13 February 2018

The outs and the ins of sphingosine-1-phosphate in immunity

cites work

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"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets

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Brain sphingosine-1-phosphate receptors: implication for FTY720 in the treatment of multiple sclerosis

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Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes.

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Phosphorylated FTY720 promotes astrocyte migration through sphingosine-1-phosphate receptors.

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Sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 are functionally upregulated on astrocytes under pro-inflammatory conditions

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Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

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Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis

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Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes.

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Astrocytes are active players in cerebral innate immunity

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Human Neurotrophin Receptor p75NTR Defines Differentiation-Oriented Skeletal Muscle Precursor Cells: Implications for Muscle Regeneration

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Spatially distinct and functionally independent mechanisms of axonal degeneration in a model of HIV-associated sensory neuropathy

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Blood sphingolipidomics in healthy humans: impact of sample collection methodology

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Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

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Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis

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Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome.

21 January 2018

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Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation

21 January 2018

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Transgenic inhibition of astroglial NF-kappa B leads to increased axonal sparing and sprouting following spinal cord injury

21 January 2018

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Transgenic inhibition of astroglial NF-κB protects from optic nerve damage and retinal ganglion cell loss in experimental optic neuritis.

21 January 2018

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IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system

21 January 2018

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Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity

21 January 2018

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Interleukin-17 stimulates inducible nitric oxide synthase activation in rodent astrocytes.

21 January 2018

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FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ANA.24217

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13 February 2018

PubMed ID

25043204

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13 February 2018