(Q48656158)

13 February 2018

title

Neurotoxic mechanisms of paclitaxel are local to the distal axon and independent of transport defects (English)

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13 February 2018

1 reference

1 reference

Erica L Gornstein

1

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13 February 2018

Thomas L Schwarz

series ordinal

2

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13 February 2018

language of work or name

English

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publication date

25 November 2016

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13 February 2018

published in

Experimental Neurology

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13 February 2018

volume

288

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13 February 2018

page(s)

153-166

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13 February 2018

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5568627/fullTextXML

inferred from PubMed Central ID database lookup

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Ordered recruitment of dynactin to the microtubule plus-end is required for efficient initiation of retrograde axonal transport

22 May 2018

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Mature neurons: equipped for survival

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Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: implications for chemotherapy-induced peripheral neuropathy

22 May 2018

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Long-distance retrograde neurotrophic factor signalling in neurons

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Persistent chemoneuropathy in patients receiving the plant alkaloids paclitaxel and vincristine

22 May 2018

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HDAC5 is a novel injury-regulated tubulin deacetylase controlling axon regeneration

22 May 2018

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A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration

22 May 2018

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Computational analysis of axonal transport: a novel assessment of neurotoxicity, neuronal development and functions

22 May 2018

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The chemical complexity of cellular microtubules: tubulin post-translational modification enzymes and their roles in tuning microtubule functions

22 May 2018

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Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

22 May 2018

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Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

22 May 2018

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Chemotherapy-induced peripheral neurotoxicity (CIPN): an update

22 May 2018

1 reference

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Functional deficits in peripheral nerve mitochondria in rats with paclitaxel- and oxaliplatin-evoked painful peripheral neuropathy

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Terminal arbor degeneration--a novel lesion produced by the antineoplastic agent paclitaxel

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

A family of protein-deglutamylating enzymes associated with neurodegeneration

22 May 2018

1 reference

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Tubulin polyglutamylation stimulates spastin-mediated microtubule severing

22 May 2018

1 reference

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Tsc2-Rheb signaling regulates EphA-mediated axon guidance

22 May 2018

1 reference

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Posttranslational modifications of tubulin and the polarized transport of kinesin-1 in neurons.

22 May 2018

1 reference

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Single molecule imaging reveals differences in microtubule track selection between Kinesin motors

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Paclitaxel induces axonal microtubules polar reconfiguration and impaired organelle transport: implications for the pathogenesis of paclitaxel-induced polyneuropathy

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Synaptic activation modifies microtubules underlying transport of postsynaptic cargo

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Compartmentalized microfluidic culture platform to study mechanism of paclitaxel-induced axonal degeneration

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Automated quantification of cellular traffic in living cells.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Differential trafficking of Kif5c on tyrosinated and detyrosinated microtubules in live cells

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Microtubule stabilization specifies initial neuronal polarization

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Paclitaxel induces calcium oscillations via an inositol 1,4,5-trisphosphate receptor and neuronal calcium sensor 1-dependent mechanism

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Axonal transport and neurodegenerative disease

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Peripheral neuropathy induced by microtubule-stabilizing agents.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: evidence for mitochondrial dysfunction.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Epothilones: mechanism of action and biologic activity

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Calpain inhibition protects against Taxol-induced sensory neuropathy

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Taxol impairs anterograde axonal transport of microinjected horseradish peroxidase in dorsal root ganglia neurons in vitro

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Screening of a library of phage-displayed peptides identifies human bcl-2 as a taxol-binding protein

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Inhibition of neurite initiation and growth by taxol

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Dynamic post-translational modification of tubulin in rat cerebral cortical neurons extending neurites in culture: effects of taxol

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Combinatorial influences of paclitaxel and strain on axonal transport

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Effect of taxoid and nontaxoid site microtubule-stabilizing agents on axonal transport of mitochondria in untransfected and ECFP-htau40-transfected rat cortical neurons in culture

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

A genetic model to dissect the role of Tsc-mTORC1 in neuronal cultures

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Tubulin tyrosination navigates the kinesin-1 motor domain to axons

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Disorganized microtubules underlie the formation of retraction bulbs and the failure of axonal regeneration.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Evidence for direct axonal toxicity in vincristine neuropathy.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Cytoskeletal and Morphological Alterations Underlying Axonal Sprouting after Localized Transection of Cortical Neuron AxonsIn Vitro

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Growth cone turning induced by direct local modification of microtubule dynamics.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

WldS mice are resistant to paclitaxel (taxol) neuropathy

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5568627

Dynamic plasticity of axons within a cutaneous milieu

14 August 2018

1 reference

12 December 2020

Morphological evidence of the inhibitory effect of taxol on the fast axonal transport

1 reference

12 December 2020

Distribution of GAP-43 nerve fibers in the skin of the adult human hand

1 reference

12 December 2020

Pharmacokinetics of paclitaxel and metabolites in a randomized comparative study in platinum-pretreated ovarian cancer patients

1 reference

12 December 2020

10.1016/J.EXPNEUROL.2016.11.015

Identifiers

DOI

1 reference

13 February 2018

PMC publication ID

5568627

1 reference

13 February 2018

PubMed publication ID

27894788

1 reference

13 February 2018