(Q48715652)

14 February 2018

title

Metabolic engineering II. Eukaryotic systems. (English)

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14 February 2018

1

Martin Fussenegger

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14 February 2018

2

Michael J Betenbaugh

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14 February 2018

publication date

1 September 2002

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14 February 2018

Biotechnology and Bioengineering

published in

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14 February 2018

volume

79

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14 February 2018

issue

5

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14 February 2018

page(s)

509-531

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14 February 2018

Apoptosis in cell culture

cites work

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Toward a science of metabolic engineering

21 January 2018

1 reference

Reflections on the scope and the future of metabolic engineering and its connections to functional genomics and drug discovery

21 January 2018

1 reference

Alphaviruses as vectors for gene delivery

21 January 2018

1 reference

Novel hemoglobins to enhance microaerobic growth and substrate utilization in Escherichia coli

21 January 2018

1 reference

Comparison of picornaviral IRES-driven internal initiation of translation in cultured cells of different origins.

21 January 2018

1 reference

A temperature-regulated replicon-based DNA expression system

21 January 2018

1 reference

Genetic engineering of an industrial strain of Saccharopolyspora erythraea for stable expression of the Vitreoscilla haemoglobin gene (vhb).

21 January 2018

1 reference

A 9-nt segment of a cellular mRNA can function as an internal ribosome entry site (IRES) and when present in linked multiple copies greatly enhances IRES activity

21 January 2018

1 reference

A 5' Leader of Rbm3, a Cold Stress-induced mRNA, Mediates Internal Initiation of Translation with Increased Efficiency under Conditions of Mild Hypothermia

21 January 2018

1 reference

Intracellular expression of Vitreoscilla hemoglobin alters the aerobic metabolism of Saccharomyces cerevisiae

21 January 2018

1 reference

Efficient gene delivery into adult cardiomyocytes by recombinant Sindbis virus

21 January 2018

1 reference

Dicistronic transcription units for gene expression in mammalian cells

21 January 2018

1 reference

Expressing creatine kinase in transgenic tobacco--a first step towards introducing an energy buffering system in plants

21 January 2018

1 reference

A transcriptional regulator of a pristinamycin resistance gene in Streptomyces coelicolor

21 January 2018

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Expression of Alcaligenes eutrophus flavohemoprotein and engineered Vitreoscilla hemoglobin-reductase fusion protein for improved hypoxic growth of Escherichia coli

21 January 2018

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Dissection of central carbon metabolism of hemoglobin-expressing Escherichia coli by 13C nuclear magnetic resonance flux distribution analysis in microaerobic bioprocesses.

21 January 2018

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Novel pristinamycin-responsive expression systems for plant cells

21 January 2018

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The impact of mammalian gene regulation concepts on functional genomic research, metabolic engineering, and advanced gene therapies

21 January 2018

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Molecular regulation of cell-cycle progression and apoptosis in mammalian cells: implications for biotechnology

21 January 2018

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Genetic optimization of recombinant glycoprotein production by mammalian cells

21 January 2018

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A mathematical model of caspase function in apoptosis.

21 January 2018

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Regulated overexpression of the survival factor bcl-2 in CHO cells increases viable cell density in batch culture and decreases DNA release in extended fixed-bed cultivation

21 January 2018

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A novel cytostatic process enhances the productivity of Chinese hamster ovary cells.

21 January 2018

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pTRIDENT, a novel vector family for tricistronic gene expression in mammalian cells

21 January 2018

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Streptogramin-based gene regulation systems for mammalian cells

21 January 2018

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Autoregulated multicistronic expression vectors provide one-step cloning of regulated product gene expression in mammalian cells

21 January 2018

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pQuattro vectors allow one-step multigene metabolic engineering and auto-selection of quattrocistronic artificial mammalian operons

21 January 2018

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Regulated multicistronic expression technology for mammalian metabolic engineering

21 January 2018

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Controlled proliferation by multigene metabolic engineering enhances the productivity of Chinese hamster ovary cells

21 January 2018

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Streptogramin- and tetracycline-responsive dual regulated expression of p27(Kip1) sense and antisense enables positive and negative growth control of Chinese hamster ovary cells

21 January 2018

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Enhanced productivity during controlled proliferation of BHK cells in continuously perfused bioreactors

21 January 2018

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Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

21 January 2018

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Targeted expression of a synthetic codon optimized gene, encoding the spruce budworm antifreeze protein, leads to accumulation of antifreeze activity in the apoplasts of transgenic tobacco

21 January 2018

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Transgenic tobacco expressing Vitreoscilla hemoglobin exhibits enhanced growth and altered metabolite production.

21 January 2018

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rRNA-complementarity in the 5' untranslated region of mRNA specifying the Gtx homeodomain protein: evidence that base- pairing to 18S rRNA affects translational efficiency

21 January 2018

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Genetic regulatory mechanisms in the synthesis of proteins

21 January 2018

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Intracellular expression of Vitreoscilla hemoglobin (VHb) enhances total protein secretion and improves the production of alpha-amylase and neutral protease in Bacillus subtilis.

21 January 2018

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Use of antibodies for detection of phosphorylated proteins separated by two-dimensional gel electrophoresis

21 January 2018

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Influence of low temperature on productivity, proteome and protein phosphorylation of CHO cells

21 January 2018

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Heterologous expression of a bacterial haemoglobin improves the growth properties of recombinant Escherichia coli

21 January 2018

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The Vitreoscilla hemoglobin gene: molecular cloning, nucleotide sequence and genetic expression in Escherichia coli

21 January 2018

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Evidence for partial export of Vitreoscilla hemoglobin into the periplasmic space in Escherichia coli. Implications for protein function

21 January 2018

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A high-throughput alphavirus-based expression cloning system for mammalian cells.

21 January 2018

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Two-dimensional electrophoresis of proteins as a tool in the metabolic engineering of cell cycle regulation.

21 January 2018

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Deregulated expression of cloned transcription factor E2F-1 in Chinese hamster ovary cells shifts protein patterns and activates growth in protein-free medium

21 January 2018

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Glycosylation and biological activity of CAMPATH-1H expressed in different cell lines and grown under different culture conditions

21 January 2018

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Overcoming apoptosis: new methods for improving protein-expression systems

21 January 2018

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Mathematical modeling of the effects of ammonium ion on the intracellular pH of hybridoma cells

21 January 2018

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Flow effects on the viability and lysis of suspended mammalian cells

21 January 2018

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Tissue plasminogen activator coexpressed in Chinese hamster ovary cells with alpha(2,6)-sialyltransferase contains NeuAc alpha(2,6)Gal beta(1,4)Glc-N-AcR linkages

21 January 2018

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Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage

21 January 2018

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Dual-regulated expression technology: a new era in the adjustment of heterologous gene expression in mammalian cells

21 January 2018

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Recombinant glycoprotein product quality in proliferation-controlled BHK-21 cells

21 January 2018

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Regulation of transcription of the mph(A) gene for macrolide 2'-phosphotransferase I in Escherichia coli: characterization of the regulatory gene mphR(A).

21 January 2018

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Translation of NRF mRNA is mediated by highly efficient internal ribosome entry

21 January 2018

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Effect of Vitreoscilla hemoglobin expression on growth and specific tissue plasminogen activator productivity in recombinant chinese hamster ovary cells

21 January 2018

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Effect of cloned gene dosage on cell growth and hepatitis B surface antigen synthesis and secretion in recombinant CHO cells

21 January 2018

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Recombinant cyclin E expression activates proliferation and obviates surface attachment of chinese hamster ovary (CHO) cells in protein-free medium

21 January 2018

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Starting at the beginning, middle, and end: translation initiation in eukaryotes

21 January 2018

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Unusual regulatory mechanism for a Streptomyces multidrug resistance gene, ptr, involving three homologous protein-binding sites overlapping the promoter region.

21 January 2018

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Synthesis of bisected glycoforms of recombinant IFN-beta by overexpression of beta-1,4-N-acetylglucosaminyltransferase III in Chinese hamster ovary cells

21 January 2018

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Novel surface tagging technology for selection of complex proliferation-controlled mammalian cell phenotypes

21 January 2018

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SAMY, a novel mammalian reporter gene derived from Bacillus stearothermophilus alpha-amylase

21 January 2018

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CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein

21 January 2018

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Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression

21 January 2018

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A mathematical model of N-linked glycoform biosynthesis.

21 January 2018

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Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity

21 January 2018

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Effect of glycosylation on antibody function: implications for genetic engineering

21 January 2018

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Analysis of inducers of the E.coli lac repressor system in mammalian cells and whole animals

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIT.10405

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14 February 2018

PubMed ID

12209823

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14 February 2018