(Q48747768)

English

Ranolazine antagonizes catecholamine-induced dysfunction in isolated cardiomyocytes, but lacks long-term therapeutic effects in vivo in a mouse model of hypertrophic cardiomyopathy.

scientific article published on 3 November 2015

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

15 February 2018

http://europepmc.org/abstract/MED/26531128

Ranolazine antagonizes catecholamine-induced dysfunction in isolated cardiomyocytes, but lacks long-term therapeutic effects in vivo in a mouse model of hypertrophic cardiomyopathy. (English)

1 reference

Europe PubMed Central

PubMed publication ID

15 February 2018

http://europepmc.org/abstract/MED/26531128

Konstantina Stathopoulou

8

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26531128%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Felix W Friedrich

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26531128%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

author name string

Frederik Flenner

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26531128%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Nele Ungeheuer

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26531128%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Torsten Christ

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26531128%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Birgit Geertz

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26531128%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Silke Reischmann

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26531128%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Stefan Wagner

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26531128%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Klaus-Dieter Söhren

9

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26531128%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Florian Weinberger

10

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26531128%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Edzard Schwedhelm

11

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26531128%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Friederike Cuello

12

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26531128%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Lars S Maier

13

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26531128%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Thomas Eschenhagen

14

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26531128%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Lucie Carrier

15

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26531128%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

publication date

3 November 2015

1 reference

Europe PubMed Central

PubMed publication ID

15 February 2018

http://europepmc.org/abstract/MED/26531128

Cardiovascular Research

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26531128%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

109

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26531128%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26531128%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

90-102

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26531128%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Classification of the cardiomyopathies: a position statement from the European Society Of Cardiology Working Group on Myocardial and Pericardial Diseases.

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Genetics of hypertrophic and dilated cardiomyopathy

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

The molecular genetic basis for hypertrophic cardiomyopathy

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Diagnostic, prognostic, and therapeutic implications of genetic testing for hypertrophic cardiomyopathy

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Cardiac myosin-binding protein C (MYBPC3) in cardiac pathophysiology

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Tissue Doppler imaging consistently detects myocardial abnormalities in patients with hypertrophic cardiomyopathy and provides a novel means for an early diagnosis before and independently of hypertrophy

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Diastolic abnormalities as the first feature of hypertrophic cardiomyopathy in Dutch myosin-binding protein C founder mutations

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Genetic advances in sarcomeric cardiomyopathies: state of the art.

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Targets for therapy in sarcomeric cardiomyopathies

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Mechanisms of disease: hypertrophic cardiomyopathy

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Research priorities in sarcomeric cardiomyopathies

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Animal and in silico models for the study of sarcomeric cardiomyopathies

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function.

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Cardiac myosin-binding protein C is required for complete relaxation in intact myocytes

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Lys184 deletion in troponin I impairs relaxation kinetics and induces hypercontractility in murine cardiac myofibrils.

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Cardiac myosin-binding protein C mutations and hypertrophic cardiomyopathy: haploinsufficiency, deranged phosphorylation, and cardiomyocyte dysfunction

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Inotropic stimulation induces cardiac dysfunction in transgenic mice expressing a troponin T (I79N) mutation linked to familial hypertrophic cardiomyopathy

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Expression of cTnI-R145G affects shortening properties of adult rat cardiomyocytes

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility.

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Cardiac troponin T mutation R141W found in dilated cardiomyopathy stabilizes the troponin T-tropomyosin interaction and causes a Ca2+ desensitization

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Length and protein kinase A modulations of myocytes in cardiac myosin binding protein C-deficient mice

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

The usefulness of ranolazine for the treatment of refractory chronic stable angina pectoris as determined from a systematic review of randomized controlled trials

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Mechanisms of ranolazine's dual protection against atrial and ventricular fibrillation

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Effects of ranolazine on torsades de pointes tachycardias in a healthy isolated rabbit heart model

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Electrophysiologic characteristics and pharmacologic response of human cardiomyocytes isolated from a patient with hypertrophic cardiomyopathy

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Nonsense-mediated mRNA decay and ubiquitin-proteasome system regulate cardiac myosin-binding protein C mutant levels in cardiomyopathic mice

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Mybpc3 gene therapy for neonatal cardiomyopathy enables long-term disease prevention in mice

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Repair of Mybpc3 mRNA by 5'-trans-splicing in a Mouse Model of Hypertrophic Cardiomyopathy

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Rescue of cardiomyopathy through U7snRNA-mediated exon skipping in Mybpc3-targeted knock-in mice

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failure

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Protein kinase C alpha and epsilon phosphorylation of troponin and myosin binding protein C reduce Ca2+ sensitivity in human myocardium

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Theoretical model for the cooperative equilibrium binding of myosin subfragment 1 to the actin-troponin-tropomyosin complex

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Simple, sensitive and rapid liquid chromatography/atmospheric pressure chemical ionization mass spectrometric method for the quantitation of Ranolazine in rat plasma

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Evidence that ranolazine behaves as a weak beta1- and beta2-adrenoceptor antagonist in the rat [correction of cat] cardiovascular system

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

2011 ACCF/AHA guideline for the diagnosis and treatment of hypertrophic cardiomyopathy: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Pharmacological treatment options for hypertrophic cardiomyopathy: high time for evidence

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Advances in medical treatment of hypertrophic cardiomyopathy

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Mechanical and energetic consequences of HCM-causing mutations

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Hypertrophic cardiomyopathy is predominantly a disease of left ventricular outflow tract obstruction

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Contemporary insights and strategies for risk stratification and prevention of sudden death in hypertrophic cardiomyopathy

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Differential cardiac remodeling in preload versus afterload

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Tubulin polymerization disrupts cardiac β-adrenergic regulation of late INa.

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

NADPH oxidase 2 mediates angiotensin II-dependent cellular arrhythmias via PKA and CaMKII.

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Late sodium current inhibition as a new cardioprotective approach

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Ranolazine inhibits an oxidative stress-induced increase in myocyte sodium and calcium loading during simulated-demand ischemia

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Altered Na(+) currents in atrial fibrillation effects of ranolazine on arrhythmias and contractility in human atrial myocardium

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Antiadrenergic and hemodynamic effects of ranolazine in conscious dogs

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

I-1-deficiency negatively impacts survival in a cardiomyopathy mouse model.

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Effect of treatment with atenolol on 5-year survival in cats with preclinical (asymptomatic) hypertrophic cardiomyopathy.

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

The effect of atenolol on NT-proBNP and troponin in asymptomatic cats with severe left ventricular hypertrophy because of hypertrophic cardiomyopathy: a pilot study.

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Impact of the CYP2D6 genotype on the clinical effects of metoprolol: a prospective longitudinal study

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

RAnoLazIne for the treatment of diastolic heart failure in patients with preserved ejection fraction: the RALI-DHF proof-of-concept study

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVV247

21 January 2018

Identifiers

10.1093/CVR/CVV247

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26531128%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

release_s7rlcfx5y5ar3h3c2vbrbgonom

1 reference

https://api.fatcat.wiki/v0/release/s7rlcfx5y5ar3h3c2vbrbgonom

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26531128%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q48747768&oldid=1843615547"