Wikidata

(Q4875407)

English

BCL2 antagonist/killer 1

mammalian protein found in Homo sapiens

  • apoptosis regulator BAK
  • bcl-2-like protein 7
  • pro-apoptotic protein BAK
  • BCL2-like 7 protein
  • BAK1
  • bcl-2 homologous antagonist/killer
  • bcl2-L-7
In more languages

Statements

molecular function
protein binding
determination method
IPI
31 references
retrieved
8 April 2019
stated in
A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region
GOA
curator
UniProt
UniProt protein ID
Q16611
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
GOA
curator
UniProt
UniProt protein ID
Q16611
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
BID-induced structural changes in BAK promote apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
An empirical framework for binary interactome mapping
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
Mcl-1(128-350) fragment induces apoptosis through direct interaction with Bax
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
BAK multimerization for apoptosis, but not bid binding, is inhibited by negatively charged residue in the BAK hydrophobic groove
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
High-throughput methods to detect dimerization of Bcl-2 family proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
Human Bop is a novel BH3-only member of the Bcl-2 protein family
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
Tumor necrosis factor-alpha induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
Heterodimerization of BAK and MCL-1 activated by detergent micelles
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
identical protein binding
determination method
IPI
5 references
retrieved
8 April 2019
stated in
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
BAK multimerization for apoptosis, but not bid binding, is inhibited by negatively charged residue in the BAK hydrophobic groove
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
retrieved
8 April 2019
stated in
BH3 domains other than Bim and Bid can directly activate Bax/Bak
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16611
determination method
IPI
cell component
biological process
Gene Atlas image
PBB GE BAK1 203728 at fs.png
732 × 530; 11 KB
0 references

Identifiers

PDB structure ID
 
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