(Q48786061)

English

Tissue plasminogen activator induces microglial inflammation via a noncatalytic molecular mechanism involving activation of mitogen-activated protein kinases and Akt signaling pathways and AnnexinA2 and Galectin-1 receptors.

scientific article published on 7 December 2011

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scholarly article

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Europe PubMed Central

PubMed publication ID

15 February 2018

http://europepmc.org/abstract/MED/22162045

Tissue plasminogen activator induces microglial inflammation via a noncatalytic molecular mechanism involving activation of mitogen-activated protein kinases and Akt signaling pathways and AnnexinA2 and Galectin-1 receptors. (English)

1 reference

Europe PubMed Central

PubMed publication ID

15 February 2018

http://europepmc.org/abstract/MED/22162045

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based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

6

1 reference

Europe PubMed Central

PubMed publication ID

15 February 2018

http://europepmc.org/abstract/MED/22162045

8

1 reference

Europe PubMed Central

PubMed publication ID

15 February 2018

http://europepmc.org/abstract/MED/22162045

object named as

Joan Serratosa

4

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author name string

David Pineda

1

1 reference

Europe PubMed Central

PubMed publication ID

15 February 2018

http://europepmc.org/abstract/MED/22162045

Coral Ampurdanés

2

1 reference

Europe PubMed Central

PubMed publication ID

15 February 2018

http://europepmc.org/abstract/MED/22162045

Manel G Medina

3

1 reference

Europe PubMed Central

PubMed publication ID

15 February 2018

http://europepmc.org/abstract/MED/22162045

Josep Maria Tusell

5

1 reference

Europe PubMed Central

PubMed publication ID

15 February 2018

http://europepmc.org/abstract/MED/22162045

Anna M Planas

7

1 reference

Europe PubMed Central

PubMed publication ID

15 February 2018

http://europepmc.org/abstract/MED/22162045

publication date

7 December 2011

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Europe PubMed Central

PubMed publication ID

15 February 2018

http://europepmc.org/abstract/MED/22162045

1 reference

Europe PubMed Central

PubMed publication ID

15 February 2018

http://europepmc.org/abstract/MED/22162045

60

1 reference

Europe PubMed Central

PubMed publication ID

15 February 2018

http://europepmc.org/abstract/MED/22162045

4

1 reference

Europe PubMed Central

PubMed publication ID

15 February 2018

http://europepmc.org/abstract/MED/22162045

526-540

1 reference

Europe PubMed Central

PubMed publication ID

15 February 2018

http://europepmc.org/abstract/MED/22162045

Tissue plasminogen activator in murine exocrine pancreas cancer: selective expression in ductal tumors and contribution to cancer progression.

1 reference

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21 January 2018

Thermodynamic binding studies of bivalent oligosaccharides to galectin-1, galectin-3, and the carbohydrate recognition domain of galectin-3.

1 reference

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21 January 2018

Inflammation and Alzheimer's disease

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Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein induce Akt phosphorylation in the ischemic brain

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Deficiency of fibrinolytic enzyme activities in the serum of patients with Alzheimer-type dementia.

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The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors

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Surveillance, intervention and cytotoxicity: is there a protective role of microglia?

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Translocation of Akt/PKB to the nucleus of osteoblast-like MC3T3-E1 cells exposed to proliferative growth factors

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Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry

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21 January 2018

Galectin-1: a small protein with major functions

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21 January 2018

Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin.

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21 January 2018

The roles of TNF in brain dysfunction and disease

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Tissue-type plasminogen activator: a historical perspective and personal account

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21 January 2018

Production of superoxide anions by a CNS macrophage, the microglia

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Cellular survival: a play in three Akts

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21 January 2018

Cellular forms and functions of brain microglia

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21 January 2018

Specific interaction of tissue-type plasminogen activator (t-PA) with annexin II on the membrane of pancreatic cancer cells activates plasminogen and promotes invasion in vitro

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21 January 2018

Regulation of neuronal survival by the serine-threonine protein kinase Akt

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21 January 2018

Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus

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21 January 2018

Neuroinflammation in Alzheimer's disease and prion disease.

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21 January 2018

Galectin-1 Augments Ras Activation and Diverts Ras Signals to Raf-1 at the Expense of Phosphoinositide 3-Kinase

1 reference

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21 January 2018

Plasmin cleaves Abeta42 in vitro and prevents its aggregation into beta-pleated sheet structures.

1 reference

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21 January 2018

Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-methyl-D-aspartate receptor signaling

1 reference

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21 January 2018

Galectin-1 interacts with the {alpha}5{beta}1 fibronectin receptor to restrict carcinoma cell growth via induction of p21 and p27.

1 reference

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21 January 2018

Beta-amyloid stimulates murine postnatal and adult microglia cultures in a unique manner.

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21 January 2018

Microglia as mediators of inflammatory and degenerative diseases

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21 January 2018

The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells

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21 January 2018

Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression

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21 January 2018

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.

1 reference

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21 January 2018

Amyloid-beta peptides induce cell proliferation and macrophage colony-stimulating factor expression via the PI3-kinase/Akt pathway in cultured Ra2 microglial cells

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21 January 2018

Nonproteolytic neuroprotection by human recombinant tissue plasminogen activator

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21 January 2018

Microglia: a sensor for pathological events in the CNS

1 reference

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21 January 2018

Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains

1 reference

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21 January 2018

Upregulation of tPA/plasminogen proteolytic system in the periphery of amyloid deposits in the Tg2576 mouse model of Alzheimer's disease

1 reference

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21 January 2018

tPA activates LDL receptor-related protein 1-mediated mitogenic signaling involving the p90RSK and GSK3beta pathway

1 reference

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21 January 2018

Beta-amyloid protein structure determines the nature of cytokine release from rat microglia.

1 reference

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21 January 2018

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1 reference

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21 January 2018

Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro.

1 reference

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21 January 2018

Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation

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21 January 2018

JNK and p38 stresskinases--degenerative effectors of signal-transduction-cascades in the nervous system

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21 January 2018

Neuronal degeneration and a decrease in laminin-like immunoreactivity is associated with elevated tissue-type plasminogen activator in the rat hippocampus after kainic acid injection

1 reference

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21 January 2018

The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling.

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21 January 2018

Tissue plasminogen activator induces pancreatic cancer cell proliferation by a non-catalytic mechanism that requires extracellular signal-regulated kinase 1/2 activation through epidermal growth factor receptor and annexin A2.

1 reference

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21 January 2018

Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors

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21 January 2018

Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation

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21 January 2018

Microglia in neurodegenerative disease

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Murine brain macrophages induced NMDA receptor mediated neurotoxicity in vitro by secreting glutamate

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Macrophage-induced cytotoxicity of N-methyl-D-aspartate receptor positive neurons involves excitatory amino acids rather than reactive oxygen intermediates and cytokines

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21 January 2018

Mitogen-activated protein kinases activated by lipopolysaccharide and beta-amyloid in cultured rat microglia.

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21 January 2018

Galectin-1 is a novel functional receptor for tissue plasminogen activator in pancreatic cancer.

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21 January 2018

Neurotoxic responses by microglia elicited by excitotoxic injury in the mouse hippocampus.

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Microglial cells in astroglial cultures: a cautionary note

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High-yield isolation of murine microglia by mild trypsinization.

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Lipopolysaccharide and pneumococcal cell wall components activate the mitogen activated protein kinases (MAPK) erk-1, erk-2, and p38 in astrocytes

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Galectin-1: a bifunctional regulator of cellular proliferation

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Reactive microgliosis

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Inhibition of granulocyte-macrophage colony-stimulating factor signaling and microglial proliferation by anti-CD45RO: role of Hck tyrosine kinase and phosphatidylinositol 3-kinase/Akt.

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Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention

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Tissue plasminogen activator for acute ischemic stroke

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Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator.

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Neuronal cell death and tPA.

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A beta oligomers - a decade of discovery

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Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice

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Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia

1 reference

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21 January 2018

The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brain

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Decreased galectin-1 immunoreactivity of the skin in amyotrophic lateral sclerosis

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Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures

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beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.

1 reference

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Urokinase-type and tissue-type plasminogen activators as growth factors of human fibroblasts

1 reference

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Activated human microglia produce the excitotoxin quinolinic acid

1 reference

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7 January 2021

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Microglial tissue plasminogen activator (tPA) triggers neuronal apoptosis in vitro

1 reference

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7 January 2021

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Characterization of ameboid microglia isolated from developing mammalian brain.

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7 January 2021

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beta-Amyloid protein-dependent nitric oxide production from microglial cells and neurotoxicity

1 reference

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Findings from the reanalysis of the NINDS tissue plasminogen activator for acute ischemic stroke treatment trial

1 reference

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7 January 2021

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inferred from DOI database lookup

Microglial cell population dynamics in the injured adult central nervous system

1 reference

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7 January 2021

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inferred from DOI database lookup

The sphingomyelin/ceramide pathway is involved in ERK1/2 phosphorylation, cell proliferation, and uPAR overexpression induced by tissue-type plasminogen activator.

1 reference

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7 January 2021

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beta-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes.

1 reference

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7 January 2021

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Regulation of neuronal and glial galectin-1 expression by peripheral and central axotomy of rat primary afferent neurons

1 reference

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7 January 2021

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The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta (Abeta) degradation and inhibits Abeta-induced neurodegeneration.

1 reference

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7 January 2021

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Cell Type-Specific Roles for Tissue Plasminogen Activator Released by Neurons or Microglia after Excitotoxic Injury

1 reference

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7 January 2021

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inferred from DOI database lookup

Tissue plasminogen activator mediates microglial activation via its finger domain through annexin II.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Astrocytes enhance lipopolysaccharide-induced nitric oxide production by microglial cells

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22284

7 January 2021

based on heuristic

inferred from DOI database lookup

The plasmin system is induced by and degrades amyloid-beta aggregates

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Tissue plasminogen activator requires plasminogen to modulate amyloid-beta neurotoxicity and deposition

1 reference

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7 January 2021

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inferred from DOI database lookup

Tissue plasminogen activator increases canine endothelial cell proliferation rate through a plasmin-independent, receptor-mediated mechanism

1 reference

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7 January 2021

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Microglia as a unique cellular target in the treatment of stroke: potential neurotoxic mediators produced by activated microglia.

1 reference

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7 January 2021

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Identifiers

10.1002/GLIA.22284

1 reference

Europe PubMed Central

PubMed publication ID

15 February 2018

http://europepmc.org/abstract/MED/22162045

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

15 February 2018

http://europepmc.org/abstract/MED/22162045

ResearchGate publication ID

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