(Q48852162)

16 February 2018

title

Toward an improved prediction of human in vivo brain penetration (English)

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16 February 2018

author

Roger N. Gunn

5

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16 February 2018

author name string

S G Summerfield

1

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16 February 2018

A J Lucas

2

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16 February 2018

R A Porter

3

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16 February 2018

P Jeffrey

4

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16 February 2018

K R Read

6

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16 February 2018

A J Stevens

7

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16 February 2018

A C Metcalf

8

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16 February 2018

M C Osuna

9

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16 February 2018

P J Kilford

10

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16 February 2018

J Passchier

11

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16 February 2018

A D Ruffo

12

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16 February 2018

language of work or name

English

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publication date

1 December 2008

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16 February 2018

published in

Xenobiotica

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16 February 2018

volume

38

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16 February 2018

issue

12

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16 February 2018

page(s)

1518-1535

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16 February 2018

Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein

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21 January 2018

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The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model

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21 January 2018

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Parametric in vivo imaging of benzodiazepine receptor distribution in human brain

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21 January 2018

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Brain sizes, surfaces, and neuronal sizes of the cortex cerebri: a stereological investigation of man and his variability and a comparison with some mammals (primates, whales, marsupials, insectivores, and one elephant)

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21 January 2018

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Validation of a tracer kinetic model for the quantification of 5-HT(2A) receptors in human brain with [(11)C]MDL 100,907.

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21 January 2018

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Use of plasma and brain unbound fractions to assess the extent of brain distribution of 34 drugs: comparison of unbound concentration ratios to in vivo p-glycoprotein efflux ratios

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Pharmacokinetic characterization of amantadine in human brain tissue

21 January 2018

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Persistence of haloperidol in human brain tissue

21 January 2018

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Distribution of venlafaxine in three postmortem cases.

21 January 2018

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Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: an experimental analysis of the role of blood-brain barrier permeability, plasma protein binding, and brain tissue binding

21 January 2018

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Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

21 January 2018

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Steady-state brain concentrations of antihistamines in rats: interplay of membrane permeability, P-glycoprotein efflux and plasma protein binding

21 January 2018

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Post-mortem toxico-kinetics of trazodone

21 January 2018

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Relationship between exposure and nonspecific binding of thirty-three central nervous system drugs in mice.

21 January 2018

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Imaging human mesolimbic dopamine transmission with positron emission tomography: I. Accuracy and precision of D(2) receptor parameter measurements in ventral striatum

21 January 2018

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21 January 2018

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21 January 2018

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Carbamazepine and carbamazepine-10, 11-epoxide concentrations in human brain

21 January 2018

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Preliminary assessment of extrastriatal dopamine D-2 receptor binding in the rodent and nonhuman primate brains using the high affinity radioligand, 18F-fallypride

21 January 2018

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Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development

21 January 2018

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Trends in the development of new medicines by UK-owned pharmaceutical companies (1964-1980).

21 January 2018

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Measurement of benzodiazepine receptor number and affinity in humans using tracer kinetic modeling, positron emission tomography, and [11C]flumazenil

21 January 2018

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Comparison of brain extracellular fluid, brain tissue, cerebrospinal fluid, and serum concentrations of antiepileptic drugs measured intraoperatively in patients with intractable epilepsy

21 January 2018

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The importance of blood collection site for the determination of basic drugs: a case with fluoxetine and diphenhydramine overdose.

21 January 2018

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Fluoxetine overdose: a case report

21 January 2018

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Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

21 January 2018

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Increased drug delivery to the brain by P-glycoprotein inhibition

21 January 2018

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Quantification of Human Opiate Receptor Concentration and Affinity Using High and Low Specific Activity [11C]Diprenorphine and Positron Emission Tomography

21 January 2018

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SPM analysis of parametric (R)-[11C]PK11195 binding images: plasma input versus reference tissue parametric methods

21 January 2018

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Size and density of glial and neuronal cells within the cerebral neocortex of various insectivorian species

21 January 2018

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In vitro prediction of brain penetration - a case for free thinking?

21 January 2018

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Central nervous system drug disposition: the relationship between in situ brain permeability and brain free fraction

21 January 2018

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Improving the in vitro prediction of in vivo central nervous system penetration: integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain.

21 January 2018

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Concentration and distribution of thioridazine and metabolites in schizophrenic post-mortem brain tissue

21 January 2018

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Tissue distribution of mirtazapine and desmethylmirtazapine in a case of mirtazapine poisoning

21 January 2018

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Self-administration of cocaine and the cocaine analog RTI-113: relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys

21 January 2018

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11C-loperamide and its N-desmethyl radiometabolite are avid substrates for brain permeability-glycoprotein efflux

21 January 2018

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The redistribution of selected psychiatric drugs in post-mortem cases

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250802499459

Blood-brain barrier-specific properties of a human adult brain endothelial cell line

21 January 2018

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1096/FJ.04-3458FJE

Identifiers

DOI

10.1080/00498250802499459

1 reference

16 February 2018

1 reference

16 February 2018