(Q49165915)

18 February 2018

title

Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3. (English)

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18 February 2018

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Bo Zhong

1

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18 February 2018

Xikui Liu

2

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18 February 2018

Xiaohu Wang

3

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18 February 2018

Xindong Liu

4

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18 February 2018

Hongxiu Li

5

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18 February 2018

Bryant G Darnay

6

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18 February 2018

Xin Lin

7

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18 February 2018

Shao-Cong Sun

8

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18 February 2018

Chen Dong

9

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18 February 2018

publication date

14 May 2013

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18 February 2018

published in

Science Signaling

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18 February 2018

volume

6

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18 February 2018

issue

275

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18 February 2018

page(s)

ra35

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18 February 2018

Signaling organelles of the innate immune system

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Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25

22 May 2018

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22 May 2018

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An inactivating CYLD mutation promotes skin tumor progression by conferring enhanced proliferative, survival and angiogenic properties to epidermal cancer cells

22 May 2018

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Regulation of Toll-like receptor signaling in the innate immunity

22 May 2018

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

22 May 2018

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A20: from ubiquitin editing to tumour suppression

22 May 2018

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TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.

22 May 2018

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Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes

22 May 2018

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Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response

22 May 2018

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Regulation of adaptive immunity by the innate immune system

22 May 2018

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Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6.

22 May 2018

1 reference

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Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

22 May 2018

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Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production

22 May 2018

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Breaking the chains: structure and function of the deubiquitinases

22 May 2018

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The role of ubiquitin in NF-kappaB regulatory pathways.

22 May 2018

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Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

The UBA-UIM domains of the USP25 regulate the enzyme ubiquitination state and modulate substrate recognition.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

Deubiquitylation and regulation of the immune response

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD.

22 May 2018

1 reference

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TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

22 May 2018

1 reference

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DUBA: a deubiquitinase that regulates type I interferon production

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

Recognition of microorganisms and activation of the immune response

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

Pathogen recognition and innate immunity

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

A genomic and functional inventory of deubiquitinating enzymes

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

A Toll-like receptor recognizes bacterial DNA

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5763475

10.1126/SCISIGNAL.2003708

14 August 2018

Identifiers

DOI

1 reference

18 February 2018

PMC publication ID

5763475

1 reference

18 February 2018

PubMed publication ID

23674823

1 reference

18 February 2018