(Q49598911)

21 February 2018

title

Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes. (English)

1 reference

21 February 2018

1 reference

28

Ravi P Nargund

1 reference

21 February 2018

author name string

Liangqin Guo

1

1 reference

21 February 2018

Dann L Parker

2

1 reference

21 February 2018

Yi Zang

3

1 reference

21 February 2018

Ramzi F Sweis

4

1 reference

21 February 2018

Weiguo Liu

5

1 reference

21 February 2018

Edward C Sherer

6

1 reference

21 February 2018

Nicole Buist

7

1 reference

21 February 2018

Jenna Terebetski

8

1 reference

21 February 2018

Terri Kelly

9

1 reference

21 February 2018

Randal Bugianesi

10

1 reference

21 February 2018

Birgit T Priest

11

1 reference

21 February 2018

Karen H Dingley

12

1 reference

21 February 2018

Xiaofang Li

13

1 reference

21 February 2018

Stan Mitelman

14

1 reference

21 February 2018

Gino Salituro

15

1 reference

21 February 2018

Maria E Trujillo

16

1 reference

21 February 2018

Michele Pachanski

17

1 reference

21 February 2018

Melissa Kirkland

18

1 reference

21 February 2018

Mary Ann Powles

19

1 reference

21 February 2018

George J Eiermann

20

1 reference

21 February 2018

Yue Feng

21

1 reference

21 February 2018

Jin Shang

22

1 reference

21 February 2018

Andrew D Howard

23

1 reference

21 February 2018

Feroze Ujjainwalla

24

1 reference

21 February 2018

Christopher J Sinz

25

1 reference

21 February 2018

John S Debenham

26

1 reference

21 February 2018

Scott D Edmondson

27

1 reference

21 February 2018

William K Hagmann

29

1 reference

21 February 2018

Derun Li

30

1 reference

21 February 2018

publication date

12 October 2016

1 reference

21 February 2018

ACS Medicinal Chemistry Letters

published in

1 reference

21 February 2018

volume

7

1 reference

21 February 2018

issue

12

1 reference

21 February 2018

page(s)

1107-1111

1 reference

21 February 2018

GPR142 Agonists Stimulate Glucose-Dependent Insulin Secretion via Gq-Dependent Signaling

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150677

Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150677

Aminopyrazole-Phenylalanine Based GPR142 Agonists: Discovery of Tool Compound and in Vivo Efficacy Studies.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150677

Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150677

Triazoloamides as potent γ-secretase modulators with reduced hERG liability

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150677

Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150677

Utility of unbound plasma drug levels and P-glycoprotein transport data in prediction of central nervous system exposure

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150677

Diagnosis and classification of diabetes mellitus

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150677

Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150677

Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150677

When poor solubility becomes an issue: from early stage to proof of concept

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150677

Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150677

Dipeptidyl peptidase IV inhibitors for the treatment of diabetes

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150677

Diabetes mellitus: pathogenesis and treatment strategies

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150677

Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150677

Discovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150677

Phenylalanine derivatives as GPR142 agonists for the treatment of type II diabetes.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150677

Discovery and optimization of a novel series of GPR142 agonists for the treatment of type 2 diabetes mellitus.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150677

Estimation of the aqueous solubility I: application to organic nonelectrolytes.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150677

10.1021/ACSMEDCHEMLETT.6B00314

14 August 2018

Identifiers

DOI

1 reference

21 February 2018

PMCID

5150677

1 reference

21 February 2018

PubMed ID

27994747

1 reference

21 February 2018