(Q49882750)

23 February 2018

title

Antiepileptic drugs in development pipeline: A recent update (English)

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23 February 2018

author name string

Harjeet Kaur

series ordinal

1

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23 February 2018

Baldeep Kumar

series ordinal

2

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23 February 2018

Bikash Medhi

series ordinal

3

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23 February 2018

publication date

17 June 2016

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23 February 2018

published in

eNeurologicalSci

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23 February 2018

volume

4

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23 February 2018

page(s)

42-51

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23 February 2018

Perampanel for tonic-clonic seizures in idiopathic generalized epilepsy A randomized trial

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Efficacy and safety of perampanel in adolescent patients with drug-resistant partial seizures in three double-blind, placebo-controlled, phase III randomized clinical studies and a combined extension study

22 May 2018

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Efficacy and safety of conversion to monotherapy with eslicarbazepine acetate in adults with uncontrolled partial-onset seizures: a randomized historical-control phase III study based in North America

22 May 2018

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Once-daily USL255 as adjunctive treatment of partial-onset seizures: randomized phase III study.

22 May 2018

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Long-term safety of perampanel and seizure outcomes in refractory partial-onset seizures and secondarily generalized seizures: results from phase III extension study 307.

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USL255 extended-release topiramate: dose-proportional pharmacokinetics and tolerability in healthy volunteers

22 May 2018

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Epilepsy: Indian perspective

22 May 2018

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ILAE official report: a practical clinical definition of epilepsy

22 May 2018

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Efficacy of perampanel: a review of pooled data

22 May 2018

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Efficacy and safety of extended-release oxcarbazepine (Oxtellar XR™) as adjunctive therapy in patients with refractory partial-onset seizures: a randomized controlled trial

22 May 2018

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BGG492 (selurampanel), an AMPA/kainate receptor antagonist drug for epilepsy

22 May 2018

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Efficacy and safety of adjunctive perampanel for the treatment of refractory partial seizures: a pooled analysis of three phase III studies.

22 May 2018

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Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonist

22 May 2018

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Issues for new antiepilepsy drug development

22 May 2018

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Mechanisms of action of antiseizure drugs

22 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Quinazolinedione sulfonamides: a novel class of competitive AMPA receptor antagonists with oral activity

22 May 2018

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Interleukin-1β biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice

22 May 2018

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Thalidomide for treatment of refractory epilepsy

22 May 2018

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Progress report on new antiepileptic drugs: a summary of the Tenth Eilat Conference (EILAT X).

22 May 2018

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Mitochondrial dysfunction and oxidative stress in seizure-induced neuronal cell death.

22 May 2018

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Polyunsaturated fatty acids and epilepsy

22 May 2018

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Estimation of the burden of active and life-time epilepsy: a meta-analytic approach

22 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions

22 May 2018

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Profile of the new pyrrolidone derivative seletracetam (ucb 44212) in animal models of epilepsy

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Antiepileptic drugs during pregnancy: what is known and which AEDs seem to be safest?

22 May 2018

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The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures

22 May 2018

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Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A.

22 May 2018

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Pregabalin add-on for drug-resistant partial epilepsy

22 May 2018

1 reference

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Emerging drugs for epilepsy

22 May 2018

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Evaluation of brivaracetam, a novel SV2A ligand, in the photosensitivity model

22 May 2018

1 reference

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Clinical evaluation of ganaxolone in pediatric and adolescent patients with refractory epilepsy

22 May 2018

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22 May 2018

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22 May 2018

Seletracetam (UCB 44212)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

22 May 2018

Carisbamate (RWJ-333369)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Progress report on new antiepileptic drugs: a summary of the Eigth Eilat Conference (EILAT VIII)

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Antiepileptic drugs in development

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Sudden unexpected death in epilepsy: a review of incidence and risk factors

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Pregabalin: as adjunctive treatment of partial seizures

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

The biochemistry of neuronal necrosis: rogue biology?

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Anticonvulsant activity of pregabalin in the maximal electroshock-induced seizure assay in α2δ1 (R217A) and α2δ2 (R279A) mouse mutants.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Brivaracetam as adjunctive treatment for uncontrolled partial epilepsy in adults: a phase III randomized, double-blind, placebo-controlled trial

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Adjunctive brivaracetam in adults with uncontrolled focal epilepsy: results from a double-blind, randomized, placebo-controlled trial.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Adjunctive brivaracetam for uncontrolled focal and generalized epilepsies: results of a phase III, double-blind, randomized, placebo-controlled, flexible-dose trial.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Safety and tolerability of different titration rates of retigabine (ezogabine) in patients with partial-onset seizures

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Everolimus treatment of refractory epilepsy in tuberous sclerosis complex

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Perampanel: a novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Carisbamate as adjunctive treatment of partial onset seizures in adults in two randomized, placebo-controlled trials

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Pregabalin for the management of partial epilepsy

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Efficacy and safety of eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures: a randomized, double-blind, placebo-controlled, parallel-group phase III study

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Randomized, controlled, dose-ranging trial of carisbamate for partial-onset seizures

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Bumetanide enhances phenobarbital efficacy in a neonatal seizure model.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Pregabalin as adjunctive therapy for partial seizures

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

Evaluation of adjunctive perampanel in patients with refractory partial-onset seizures: Results of randomized global phase III study 305

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803110

A randomized, double-blind, placebo-controlled study of the efficacy, safety, and tolerability of adjunctive carisbamate treatment in patients with partial-onset seizures

30 November 2018

1 reference

12 December 2020

Retigabine as adjunctive therapy in adults with partial-onset seizures: integrated analysis of three pivotal controlled trials

1 reference

12 December 2020

Bumetanide reduces seizure frequency in patients with temporal lobe epilepsy

1 reference

12 December 2020

Discovery of 2-(2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile (perampanel): a novel, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid (AMPA) receptor antagonist

1 reference

12 December 2020

Newer anti-epileptic drugs

1 reference

12 December 2020

Intraperitoneal administration of docosahexaenoic acid for 14days increases serum unesterified DHA and seizure latency in the maximal pentylenetetrazol model

1 reference

12 December 2020

Long-term safety and efficacy of eslicarbazepine acetate in patients with focal seizures: results of the 1-year ESLIBASE retrospective study

1 reference

12 December 2020

10.1016/J.ENSCI.2016.06.003

Identifiers

DOI

1 reference

23 February 2018

PMC publication ID

5803110

1 reference

23 February 2018

PubMed publication ID

29430548

1 reference

23 February 2018