(Q34219234)

31 July 2017

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title

The biochemistry of neuronal necrosis: rogue biology? (English)

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31 July 2017

author

Nektarios Tavernarakis

series ordinal

2

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31 July 2017

Popi Syntichaki

1

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language of work or name

English

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publication date

1 August 2003

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Nature Reviews Neuroscience

31 July 2017

published in

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31 July 2017

volume

4

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31 July 2017

issue

8

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31 July 2017

page(s)

672-684

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On the origin, evolution, and nature of programmed cell death: a timeline of four billion years

31 July 2017

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31 March 2020

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31 March 2020

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Glucose deprivation depolarizes plasma membrane of cultured astrocytes and collapses transmembrane potassium and glutamate gradients

31 March 2020

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Ca2+-dependent and Ca2+-independent glutamate release, energy status and cytosolic free Ca2+ concentration in isolated nerve terminals following metabolic inhibition: possible relevance to hypoglycaemia and anoxia.

31 March 2020

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31 March 2020

Excitotoxic cell death

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Excitotoxic neurodegeneration induced by intranasal administration of kainic acid in C57BL/6 mice

31 March 2020

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Kainic acid-induced seizures produce necrotic, not apoptotic, neurons with internucleosomal DNA cleavage: implications for programmed cell death mechanisms.

31 March 2020

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Acidosis induces necrosis and apoptosis of cultured hippocampal neurons

31 March 2020

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Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures

31 March 2020

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Oxidative stress induces neuronal death by recruiting a protease and phosphatase-gated mechanism

31 March 2020

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Apoptosis in neurodegenerative disorders

31 March 2020

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Toxic proteins in neurodegenerative disease

31 March 2020

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The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration

31 March 2020

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Epithelial sodium channel related to proteins involved in neurodegeneration

31 March 2020

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Neuropathology of degenerative cell death in Caenorhabditis elegans

31 March 2020

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Apparent loss and hypertrophy of interneurons in a mouse model of neuronal ceroid lipofuscinosis: evidence for partial response to insulin-like growth factor-1 treatment

31 March 2020

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Mouse gene knockout models for the CLN2 and CLN3 forms of ceroid lipofuscinosis

31 March 2020

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Motoneuron morphological alterations before and after the onset of the disease in the wobbler mouse

31 March 2020

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Progesterone neuroprotection in the Wobbler mouse, a genetic model of spinal cord motor neuron disease.

31 March 2020

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Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

31 March 2020

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The neuronal endosomal-lysosomal system in Alzheimer's disease

31 March 2020

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Endoplasmic reticulum dysfunction--a common denominator for cell injury in acute and degenerative diseases of the brain?

31 March 2020

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

31 March 2020

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Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

31 March 2020

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Amyotrophic lateral sclerosis: recent insights from genetics and transgenic mice

31 March 2020

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Mice overexpressing the human neurofilament heavy gene as a model of ALS.

31 March 2020

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An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

31 March 2020

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A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans

31 March 2020

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An activating mutation in a Caenorhabditis elegans Gs protein induces neural degeneration

31 March 2020

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G alphas-induced neurodegeneration in Caenorhabditis elegans.

31 March 2020

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Regulation of hypoxic death in C. elegans by the insulin/IGF receptor homolog DAF-2.

31 March 2020

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Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulum

31 March 2020

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Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans

31 March 2020

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Calcium, free radicals and excitotoxins in neuronal apoptosis.

31 March 2020

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Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders

31 March 2020

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Molecular mechanisms of calcium-dependent excitotoxicity

31 March 2020

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Genetically targeted cell disruption in Caenorhabditis elegans

31 March 2020

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The nematode degenerin UNC-105 forms ion channels that are activated by degeneration- or hypercontraction-causing mutations

31 March 2020

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MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation

31 March 2020

1 reference

The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans

31 March 2020

1 reference

unc-8, a DEG/ENaC family member, encodes a subunit of a candidate mechanically gated channel that modulates C. elegans locomotion

31 March 2020

1 reference

The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel

31 March 2020

1 reference

Two functionally dependent acetylcholine subunits are encoded in a single Caenorhabditis elegans operon

31 March 2020

1 reference

Characterization of the deg-3/des-2 receptor: a nicotinic acetylcholine receptor that mutates to cause neuronal degeneration

31 March 2020

1 reference

G protein hyperactivation of the Caenorhabditis elegans adenylyl cyclase SGS-1 induces neuronal degeneration

31 March 2020

1 reference

Sodium overload through voltage-dependent Na(+) channels induces necrosis and apoptosis of rat superior cervical ganglion cells in vitro.

31 March 2020

1 reference

Dependence of vital cell function on endoplasmic reticulum calcium levels: implications for the mechanisms underlying neuronal cell injury in different pathological states

31 March 2020

1 reference

Calcium signaling: a tale for all seasons

31 March 2020

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Calreticulin comes of age

31 March 2020

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Calreticulin: one protein, one gene, many functions.

31 March 2020

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Excitement about calcium signaling in inexcitable cells

31 March 2020

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Calcium signaling in neurons: molecular mechanisms and cellular consequences

31 March 2020

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The oxidant stress hypothesis in Parkinson's disease: evidence supporting it

31 March 2020

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Oxidative nerve cell death in Alzheimer's disease and stroke: antioxidants as neuroprotective compounds

31 March 2020

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Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis.

31 March 2020

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Phenotypic effects of familial amyotrophic lateral sclerosis mutant Sod alleles in transgenic Drosophila

31 March 2020

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Protection of ischemic rat heart by dantrolene, an antagonist of the sarcoplasmic reticulum calcium release channel

31 March 2020

1 reference

Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78

31 March 2020

1 reference

Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development

31 March 2020

1 reference

Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease.

31 March 2020

1 reference

Mechanisms of glutamate-stimulated Mg2+ influx and subsequent Mg2+ efflux in rat forebrain neurones in culture

31 March 2020

1 reference

Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures

31 March 2020

1 reference

Non-pharmacologic (physiologic) neuroprotection in the treatment of brain ischemia

31 March 2020

1 reference

Zinc-induced cortical neuronal death with features of apoptosis and necrosis: mediation by free radicals

31 March 2020

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Zn(2+) induces permeability transition pore opening and release of pro-apoptotic peptides from neuronal mitochondria.

31 March 2020

1 reference

Cytosolic pH and the inflammatory microenvironment modulate cell death in human neutrophils after phagocytosis

31 March 2020

1 reference

Hyperglycemia and focal brain ischemia

31 March 2020

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Acidosis induced by hypercapnia exaggerates ischemic brain damage

31 March 2020

1 reference

Role of poly(ADP-ribose) polymerase in rapid intracellular acidification induced by alkylating DNA damage

31 March 2020

1 reference

Insulin stimulates NHE1 activity by sequential activation of phosphatidylinositol 3-kinase and protein kinase C zeta in human erythrocytes

31 March 2020

1 reference

Degradation of tau by lysosomal enzyme cathepsin D: implication for Alzheimer neurofibrillary degeneration.

31 March 2020

1 reference

Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution

31 March 2020

1 reference

Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates

31 March 2020

1 reference

Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer's disease.

31 March 2020

1 reference

Elevated cathepsin D expression in kainate-evoked rat brain neurodegeneration

31 March 2020

1 reference

A selective cysteine protease inhibitor is non-toxic and cerebroprotective in rats undergoing transient middle cerebral artery ischemia

31 March 2020

1 reference

Regionally selective changes in brain lysosomes occur in the transition from young adulthood to middle age in rats

31 March 2020

1 reference

Cytosolic proteolysis of tau by cathepsin D in hippocampus following suppression of cathepsins B and L.

31 March 2020

1 reference

Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene

31 March 2020

1 reference

Recent advances in elucidating Niemann-Pick C disease

31 March 2020

1 reference

Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus.

31 March 2020

1 reference

The genetic association between Cathepsin D and Alzheimer's disease.

31 March 2020

1 reference

31 March 2020

1 reference

Crucial role of calpain in hypoxic PC12 cell death: calpain, but not caspases, mediates degradation of cytoskeletal proteins and protein kinase C-alpha and -delta

31 March 2020

1 reference

Phosphoinositide 3-kinase accelerates calpain-dependent proteolysis of fodrin during hypoxic cell death

31 March 2020

1 reference

Mitochondrial Ca(2+)homeostasis in the regulation of apoptotic and necrotic cell deaths

31 March 2020

1 reference

Calpain and caspase: can you tell the difference?

31 March 2020

1 reference

Downregulation of the calpain inhibitor protein calpastatin by caspases during renal ischemia-reperfusion

31 March 2020

1 reference

Cleavage of plasma membrane calcium pumps by caspases: a link between apoptosis and necrosis

31 March 2020

1 reference

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

31 March 2020

1 reference

The potassium channel opener (-)-cromakalim prevents glutamate-induced cell death in hippocampal neurons.

31 March 2020

1 reference

Alterations of Extracellular Calcium Elicit Selective Modes of Cell Death and Protease Activation in SH-SY5Y Human Neuroblastoma Cells

31 March 2020

1 reference

Calbindin-D28k buffers intracellular calcium and promotes resistance to degeneration in PC12 cells

31 March 2020

1 reference

Postictal blockade of ischemic hippocampal neuronal death in primates using selective cathepsin inhibitors

31 March 2020

1 reference

Neuroprotective effects of pyridoxal phosphate and pyridoxal against ischemia in monkeys.

31 March 2020

1 reference

Programmed cell death in Caenorhabditis elegans

31 March 2020

1 reference

Programmed cell death: alive and well in the new millennium

31 March 2020

1 reference

Protein misfolding and disease; protein refolding and therapy

31 March 2020

1 reference

From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS

31 March 2020

1 reference

Neurodegeneration. Battling the killer proteins

31 March 2020

1 reference

Unfolding the role of protein misfolding in neurodegenerative diseases

31 March 2020

1 reference

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

31 March 2020

1 reference

Impairment of the ubiquitin-proteasome system by protein aggregation

31 March 2020

1 reference

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

31 March 2020

1 reference

A Drosophila model of Parkinson's disease

31 March 2020

1 reference

Genetic suppression of polyglutamine toxicity in Drosophila

31 March 2020

1 reference

Suppression of polyglutamine-induced protein aggregation in Caenorhabditis elegans by torsin proteins

31 March 2020

1 reference

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.

31 March 2020

1 reference

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

31 March 2020

1 reference

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

31 March 2020

1 reference

Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans

31 March 2020

1 reference

Interaction of intracellular beta amyloid peptide with chaperone proteins

31 March 2020

1 reference

Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans

31 March 2020

1 reference

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

31 March 2020

1 reference

Primate neurons show different vulnerability to transient ischemia and response to cathepsin inhibition

31 March 2020

1 reference

Inflammatory response in acute traumatic brain injury: a double-edged sword

31 March 2020

1 reference

Preconditioned resistance to oxygen-glucose deprivation-induced cortical neuronal death: alterations in vesicular GABA and glutamate release

31 March 2020

1 reference

Seizures accelerate anoxia-induced neuronal death in the neonatal rat hippocampus

31 March 2020

1 reference

Seizure-induced neuronal injury: animal data

31 March 2020

1 reference

Rapid ischemic cell death in immature oligodendrocytes: a fatal glutamate release feedback loop

31 March 2020

1 reference

The changing face of the Na+/H+ exchanger, NHE1: structure, regulation, and cellular actions

31 March 2020

1 reference

Structure, function and regulation of the vacuolar (H+)-ATPase

31 March 2020

1 reference

Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on 'calpain-cathepsin hypothesis'.

31 March 2020

1 reference

31 March 2020

1 reference

Mitochondria are selectively eliminated from eukaryotic cells after blockade of caspases during apoptosis

31 March 2020

1 reference

Calcium in ischemic cell death

31 March 2020

1 reference

Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart

31 March 2020

1 reference

The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

31 March 2020

1 reference

Excitotoxicity and mitochondria

31 March 2020

1 reference

Vitamin B6 protects primate retinal neurons from ischemic injury

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRN1174

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Dimensions Publication ID

31 July 2017

1036289445

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